Conditions Associated with HHV-6

Since its discovery in 1986, HHV-6 has been associated with a wide array of clinical conditions—many of which are listed in the menu at right. While the relationship between HHV-6 infection and some of these diseases are well established, the role of HHV-6 in many other conditions remains unclear. In addition to causing “acute” disease such as encephalitis, HHV-6 can also persist as a chronic infection, nearly undetectable by most current diagnostic tests. This subacute form of HHV-6 is likely to contribute to the pathology of many diseases associated with HHV-6. There is an urgent need for more sensitive diagnostic assays and studies that can prove or disprove the important disease associations that have been suggested.

Established Disease Assocations

Transplant Complications

  • Bone marrow supression
  • Colitis/diarrhea
  • Delirium/CNS Dysfunction
  • Encephalitis/Amnesia
  • GVHD
  • Hemophagocytic syndrome
  • Hepatitis /Liver failure
  • Pneumonitis
  • Transplant Reactivation Overview


  • Encephalitis / Meningitis Overview
  • Encephalitis in the Immunocompromised
  • Encephalitis in the Immunocompetent
  • Rhomboencephalitis
  • Limbic Encephalitis
  • Encephalomyelitis
  • Amnesia

Rash & Roseola


  • Febrile Seizures
  • Status Epilepticus

Cognitive Dysfunction

  • Delirium
  • Amnesia

Hypersensitivity (DIHS/DRESS)

  • Drug Induced Hypersensitivity Syndrome (DIHS)
  • Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS)
  • Stevens-Johnson Syndrome (SJS)

Immune Suppression

  • Bone Marrow Suppression


Possible Disease Associations

Multiple Sclerosis

Chronic Fatigue Syndrome


  • Mesial/Temporal Lobe Epilepsy
  • Status Epilepticus


Endocrine Disorders

Heart Disease

  • Myocarditis
  • Left Ventricle Disfunction
  • Arteriopathies

Hemophagocytic Conditions

  • Hemophagocytic Syndrome/ Histiocytosis

HIV/AIDS Progression

Liver Disease

  • Hepatitis
  • HIV/AIDS Progression

Lung Disease

  • Organizing Pneumonia
  • Pneumonitis


  • Hodgkin's Lymphoma
  • Gliomas
  • Cervical Cancer

Kidney Disease

Autoimmune Disease

Other Associations

  • Hypogammaglobulinemia
  • Optic Neuritis
  • Microangiopathy
  • Mononucleosis
  • Uveitis
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