HHV-6A in the news!

In News by Kristin Loomis

The recent publication of “Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility” in PLOS ONE led to strong scientific and media interest across the world. The HHV-6 Foundation issued a rare press release to encourage the spread of the important results of this study, which may hold promise for many infertile couples.

Best Practices: Pubmed Searches

In News by Kristin Loomis

Searching through Pubmed for HHV-6 related research is best done with a multi-keyword approach to find the most available studies at once. Certain variations of the HHV-6 viruses and their names (forgoing the use of a dash, for example) can mislead the search into finding incomplete results. To find the most relevant results, we recommend the copying the following search string when using Pubmed.

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Philip Pellett wins Lifetime Achievement Award

In All, News by Kristin Loomis

Philip Pellett, PhD, a Professor and Interim Chair of Immunology and Microbiology at the Wayne State University School of Medicine, was awarded the HHV-6 Foundation’s Dharam Ablashi Lifetime Achievement Award at the 9th International Conference on HHV-6 & 7.

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Stanford uses non-invasive new assay to detect occult infections including HHV-6 after lung transplantion

In All, Heart Disease, News, Transplant Complications by Kristin Loomis

Researchers from Stanford University successfully used circulating cell-free DNA to identify infections in lung transplants that can often be found only with a more invasive transbronchial biopsy. This hypothesis free approach led to find HHV-6 & 7 at high levels in patients with infections, even though these viruses are not generally considered lung pathogens.

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HHV-6 myocarditis, pericarditis following transplantation

In All, Heart Disease, News, Transplant Complications by Kristin Loomis

A hematology group in Australia reported a case of biopsy-proven HHV-6 myocarditis post-hematopoietic stem cell transplantation (HSCT). he post-mortem exam confirmed dilated cardiomyopathy and focal changes consistent with viral myocarditis and cardiac tissue was positive for HHV-6 DNA by nested and quantitative PCR. Separately, A Japanese group reported a worman who developed pericarditis with over 10,000 copies/ml of HHV-6 DNA in the pericardial fluid, after a cord blood transplant.

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HHV-6 the only pathogen identified in early post-transplant CNS dysfunction

In All, CNS Dysfunction, News, Transplant Complications by Kristin Loomis

A group from Sapporo Medical University studied 105 post HSCT patients and determined that 7 developed CNS dysfunction in the first 42 days after transplant. Six out of the 7 were positive for HHV-6, but none of the other 12 pathogens tested. Four patients (3.8%) were diagnosed with HHV-6 encephalitis. The group used a qualitative multiplex PCR and then used a quantitative PCR to confirm the results.

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HHV-6 can cause “idiopathic” pneumonia

In All, Lung Disease, News by hhv6foundation

A pivotal study, led by Michael Boeckh at the Fred Hutchinson Cancer Research Center, has determined that occult infections contribute to 57% of all cases of “idiopathic” pneumonia syndrome (IPS), a condition previously assumed to be non-infectious. HHV-6 was the dominant pathogen representing 29% of cases.