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Gene-expression network analysis points to HHV-6A as a key driver in upregulating genes leading to Alzheimer’s disease progression

In All, Alzheimer's Disease, CNS Disease, CNS Dysfunction by Kristin Loomis

Investigators at Mt Sinai used “big data” models to determine that the genes involved with fighting Alzheimer’s are the same ones that fight virus. They found HHV-6A and HHV-7 to be more abundant in Alzheimer’s brains, and singled out HHV6-A as a key modulator of the genes involved in amyloidosis and neuronal death.

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HHV-6 induced amnesia after rituximab therapy for autoimmune disease

In All, CNS Dysfunction, Encephalitis & Encephalopathy, Transplant Complications by Kristin Loomis

A young woman on rituximab and two other immunomodulatory agents for the treatment of dermatomyositis developed encephalitis with severe anterograde amnesia. As the use of biologic treatments for refractory autoimmune disease has been increasing, physicians are advised to consider HHV-6 and offer prompt antiviral therapy to limit irreversible morbidity.

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HHV-6 identified in 12% of simple and 42% of complex pediatric febrile seizures

In All, CNS Disease, CNS Dysfunction, Epilepsy and Seizures by Kristin Loomis

Australian investigators studied 143 young children with febrile seizures for signs of viral infection and found that HHV-6 was the fifth most common virus after rhinovirus (22%), enterovirus (20%), adenovirus (21%) and influenza (13%). Overall, a virus was found in 71% of cases. Virus found in complex seizures was associated with HHV-6 (42%) or influenza (41%).

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Rapid point-of-care system screens for 14 encephalitis pathogens in one hour!

In All, CNS Disease, CNS Dysfunction, Encephalitis & Encephalopathy by Kristin Loomis

A new point-of-care assay from bioMérieux can simultaneously and rapidly detect 14 pathogens typically found in encephalitis. The machine is designed to be at the clinic or in the emergency room and can be operated by unskilled technicians. In a study of 1,560 immunocompetent patient samples, a total of 1.35% were positive for HHV-6, or about twice the expected rate of 0.8% found with the inherited chromosomally integrated HHV-6.

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GAD antibodies & HHV-6 limbic encephalitis – a case of molecular mimicry?

In All, Autoimmune Disease, CNS Disease, CNS Dysfunction, Encephalitis & Encephalopathy, Epilepsy and Seizures, Latest Scientific News by Kristin Loomis

A fifth case of limbic encephalitis associated with GAD antibodies and HHV-6 infection has been reported, this time in an immunocompetent woman with chromosomally integrated HHV-6, epilepsy, and psychosis. The patient’s condition improved (with a drop in GAD antibody titers and stabilization of psychotic symptoms) in response to three weeks of antiviral therapy but relapsed when antiviral therapy was withdrawn.

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HHV-6 & 7 found in spinal fluid of immunocompetent children suspected of CNS infection

In All, CNS Disease, CNS Dysfunction, Latest Scientific News by Kristin Loomis

An Italian study on immunocompetent children with suspected CNS infections found HHV-6 and HHV-7 DNA in 4.2% and 4.8% of 304 cerebrospinal fluid (CSF) samples, respectively. Although once considered rare in the immunocompetent, recent studies with more sensitive methods have found HHV-6 in the CSF of 4-17% of immunocompetent children with seizures or suspected CNS infections.