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Genome editing to clear latent herpesvirus infection

In All, Genes & Proteins, Treatments - Antiviral by Kristin Loomis

A group from the University Medical Center in the Netherlands has shown that new gene editing technology can be used to impair viral replication and clear latent herpesvirus infections. The group used a CRISPR-Cas system to target viral genetic elements that completely eliminated CMV and HSV1 replication. They were also able to clear latent EBV from transformed human tumor cells.

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The crystal structure of HHV-6B U14 defined

In All, Genes & Proteins, Molecular Biology by Kristin Loomis

A group led by Yasuko Mori in Japan has analyzed the crystal structure of HHV-6B U14, an important accomplishment for the understanding of HHV-6. Human herpesvirus 6B encodes numerous tegument proteins that make up the viral matrix. One of these tegument proteins is U14. In addition to being necessary for viral propagation, it is able to regulate host cell responses by interacting with host factors such as tumor suppressor p53.

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Superinfection of HHV-6A in ciHHV6A patients with recurrent cardiac disease: a full genome analysis

In All, ciHHV-6, Genes & Proteins, Heart Disease, Latest Scientific News by Kristin Loomis

A group led by Ursula Gompels from the London School of Hygiene & Tropical Medicine, University of London, did next generation sequencing on three ciHHV6A cardiac patients and found superinfections of HHV-6A in two of the three. They characterized the first full genome sequence of ciHHV-6A and demonstrated the inherited ciHHV6 genome was similar but distinct from known exogenous (community acquired) strains of HHV-6A .