New NIH Grants Relating to HHV-6

In News by Kristin Loomis

(This list excludes intramural grants as well as multi-year grants such as those to University of Massachusetts, Fred Hutch/University of Washington.)

Dharam Ablashi awarded honorary doctorate by University of Rhode Island

In News by Kristin Loomis

URI President David M. Dooley presented HHV-6 Scientific Director Dharam Ablashi with an honorary doctorate degree at their May 2018 graduation ceremonies. Dooley noted that the degree is awarded to “distinguished individuals, whose accomplishments exemplify our common values of integrity, honesty, compassion, creativity and civic-mindedness.” He is well-loved by hundreds in the medical and scientific community not only for his brilliant mind and work ethic, but because of the generosity with his time and advice and the courtesy he has shown to others in the field. Remarks by President Dooley upon the presentation of the reward can be viewed in this six minute video. Dharam Ablashi receiving his honorary doctorate at commencement ceremonies at University of Rhode Island. Dharam Ablashi …

Louis Flamand awarded 5-year grant on HHV-6 chromosomal integration

In News by Kristin Loomis

The Canadian Institutes of Health Research has awarded Louis Flamand, PhD,  and his Research Center at Laval University a five-year grant to continue his work on inherited chromosomally integrated HHV-6. The grant was based in part on work done with the aid the HHV-6 Foundation’s Dharam Ablashi Pilot Grant Fund. Congratulations to Louis and his team including Annie Gravel, Vanessa Collin and Isabelle Dubuc. A description of his planned objectives is copied below. Flamand: Funded Grant Objectives First, to determine the impact of HHV-6 integration on cellular homeostasis. To study this, iPSC lines from primary cells of iciHHV-6+subjects and controls, generated with the aid of a grant from the HHV-6 Foundation, will be utilized. These cells will be used to study …

HHV-6A in the news!

In News by Kristin Loomis

The recent publication of “Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility” in PLOS ONE led to strong scientific and media interest across the world. The HHV-6 Foundation issued a rare press release to encourage the spread of the important results of this study, which may hold promise for many infertile couples.

Best Practices: Pubmed Searches

In News by Kristin Loomis

Searching through Pubmed for HHV-6 related research is best done with a multi-keyword approach to find the most available studies at once. Certain variations of the HHV-6 viruses and their names (forgoing the use of a dash, for example) can mislead the search into finding incomplete results. To find the most relevant results, we recommend the copying the following search string when using Pubmed.

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Philip Pellett wins Lifetime Achievement Award

In All, News by Kristin Loomis

Philip Pellett, PhD, a Professor and Interim Chair of Immunology and Microbiology at the Wayne State University School of Medicine, was awarded the HHV-6 Foundation’s Dharam Ablashi Lifetime Achievement Award at the 9th International Conference on HHV-6 & 7.

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Stanford uses non-invasive new assay to detect occult infections including HHV-6 after lung transplantion

In All, Heart Disease, News, Transplant Complications by Kristin Loomis

Researchers from Stanford University successfully used circulating cell-free DNA to identify infections in lung transplants that can often be found only with a more invasive transbronchial biopsy. This hypothesis free approach led to find HHV-6 & 7 at high levels in patients with infections, even though these viruses are not generally considered lung pathogens.

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HHV-6 myocarditis, pericarditis following transplantation

In All, Heart Disease, News, Transplant Complications by Kristin Loomis

A hematology group in Australia reported a case of biopsy-proven HHV-6 myocarditis post-hematopoietic stem cell transplantation (HSCT). he post-mortem exam confirmed dilated cardiomyopathy and focal changes consistent with viral myocarditis and cardiac tissue was positive for HHV-6 DNA by nested and quantitative PCR. Separately, A Japanese group reported a worman who developed pericarditis with over 10,000 copies/ml of HHV-6 DNA in the pericardial fluid, after a cord blood transplant.

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HHV-6 the only pathogen identified in early post-transplant CNS dysfunction

In All, CNS Dysfunction, News, Transplant Complications by Kristin Loomis

A group from Sapporo Medical University studied 105 post HSCT patients and determined that 7 developed CNS dysfunction in the first 42 days after transplant. Six out of the 7 were positive for HHV-6, but none of the other 12 pathogens tested. Four patients (3.8%) were diagnosed with HHV-6 encephalitis. The group used a qualitative multiplex PCR and then used a quantitative PCR to confirm the results.