A sequencing study led by Ursula Gompels of London School of Hygiene & Tropical Medicine, found that 95% (19/21) of Czech ciHHV-6 malignancy and inflammatory disease patients had ciHHV6A while 65% (13/20) of a German myocarditis cohort had ciHHV-6B. The authors propose that this divergence suggests different disease links for the two viruses.
ciHHV-6 infants score 4 points lower than controls on the Bayley Mental Development Index
A group from University College London and the University of Zambia has reported that 20.5% of hospitalized infants were positive for HHV-6B, second only to CMV (24.3%). In contrast to previous studies, HHV-6A was found in only 0.3% of patients.
Scottish study finds inheritance of ciHHV-6 does not increase the risk of developing cHL
Tehran University of Medical Sciences reports HHV-6 DNA in cerebrospinal fluid (CSF) samples of 8.8% of 114 infants suspected of encephalitis.
Experts emphasize need for larger studies to determine the impact of ciHHV-6 on patient outcomes
A group led by Takashi Ichiyama has determined that serum levels of both matrix metallopreinase-9 and tissue inhibitor of metalloproeinases-1 are significantly elevated in infants with HHV-6 infection compared to controls, leading to a dysfunction of the blood brain barrier.
Immunocompetent adults are not supposed to get HHV-6 encephalitis or status epilepticus (SE) and HHV-6 testing is rarely performed in these patients. A new case report from Baylor suggests that testing for HHV-6 in these patients may be worthwhile.
Edaravone shows promise for reducing oxidation and neuronal damage in AESD.
A report published by a group from the University of Minnesota details the case of a 59-year-old male who developed non-convulsive status epilepticus and hyponatremia in addition to HHV-6 reactivation following umbilical cord blood transplantation.
New details may help advance the field of HHV-6 immunotherapy.
A group from Sapienza University in Rome has found a significantly elevated prevalence of HHV-6 and a higher viral load for EBV in the stomach and duodenum biopsies of patients with HIV compared to controls, suggesting that these viruses may contribute to the development of gastric cancer in immunocompromised patients.
Berlin Charite study shows heart failure patients with active ciHHV-6 can be treated successfully with antivirals.
Should physicians automatically discount HHV-6 if any other pathogen is found in the CSF? Should patients with both HHV-6 and EBV DNA in the CSF be treated only for EBV? These are the questions that UW group tried to sort out in this study.
Anti-HHV-6 IgG titer may be a useful prognostic factor in predicting relapsing-remitting MS clinical course