Investigators by at the University of Ferrara report intriguing alterations in intracellular regulation of HHV-6A-infected thyrocytes and T cells. HHV-6A, but not HHV-6B nor HHV-7, altered expression of several microRNAs in a pattern that is considered a marker for patients with autoimmune thyroid disease.
Investigators have found that HHV-6 DNA and mRNA are more prevalent in the autoimmune thyroiditis biopsies than in controls, according to investigators in Latvia. HHV-6 mRNA was found in 41% of the patient biopsies compared to 6% of controls.
Human herpesvirus-6 (HHV-6) has been associated with several autoimmune diseases. A recent study led by Rizzo and Caselli have found a possible link to Hashimoto’s Thyroiditis (HT). They report that HHV-6 infection correlated with higher levels of a particular type of NK cell associated with a potent release of cytokines.
HHV-6A infection of mesothelial cells causes HLA molecule modulation. This study demonstrates, for the first time, that human mesothelial cells are susceptible to HHV-6A infection. They also show that the virus causes modulated HLA expression on the cell surface, inducing the de novo expression of HLA class II and HLA-G
Case report describes two cases of DRESS related thyroiditis with very high levels of HHV-6 reactivation that go on to develop autoimmunity.
A group from Italy has linked HHV-6A to Hashimoto’s Thyroiditis, and provides evidence for autoimmune disease associated with HHV-6A and HHV-6B.