Since its discovery in 1986, HHV-6 has been associated with a wide array of clinical conditions, listed below. While the relationship between HHV-6 infection and some of these diseases are well established, the role of HHV-6 in many other conditions remains unclear.

In addition to causing “acute” disease such as encephalitis, HHV-6 can also persist as a chronic infection, nearly undetectable by most current diagnostic tests. This subacute form of HHV-6 is likely to contribute to the pathology of many diseases associated with HHV-6.

There is an urgent need for more sensitive diagnostic assays and studies that can prove or disprove the important disease associations that have been suggested.



  • Hodgkin’s Lymphoma
  • Gliomas
  • Cervical Cancer

Cognitive Dysfunction

  • Delirium
  • Amnesia


  • Encephalitis / Meningitis Overview
  • Encephalitis in the Immunocompromised
  • Encephalitis in the Immunocompetent
  • Rhomboencephalitis
  • Limbic Encephalitis
  • Encephalomyelitis
  • Amnesia

Endocrine Disorders


  • Mesial/Temporal Lobe Epilepsy
  • Status Epilepticus

Heart Disease

  • Myocarditis
  • Left Ventricle Disfunction
  • Arteriopathies

Hemophagocytic Conditions

  • Hemophagocytic Syndrome/ Histiocytosis

Hypersensitivity (DIHS/DRESS)

  • Drug Induced Hypersensitivity Syndrome (DIHS)
  • Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS)
  • Stevens-Johnson Syndrome (SJS)

Immune Suppression

  • Bone Marrow Suppression

Liver Disease

  • Hepatitis
  • HIV/AIDS Progression

Lung Disease

  • Organizing Pneumonia
  • Pneumonitis


  • Febrile Seizures
  • Status Epilepticus

Transplant Complications

  • Bone marrow supression
  • Colitis/diarrhea
  • Delirium/CNS Dysfunction
  • Encephalitis/Amnesia
  • GVHD
  • Hemophagocytic syndrome
  • Hepatitis /Liver failure
  • Pneumonitis
  • Transplant Reactivation Overview

Other Associations

  • Hypogammaglobulinemia
  • Optic Neuritis
  • Microangiopathy
  • Mononucleosis
  • Uveitis