Since its discovery in 1986, HHV-6 has been associated with a wide array of clinical conditions, listed below. While the relationship between HHV-6 infection and some of these diseases are well established, the role of HHV-6 in many other conditions remains unclear.
In addition to causing “acute” disease such as encephalitis, HHV-6 can also persist as a chronic infection, nearly undetectable by most current diagnostic tests. This subacute form of HHV-6 is likely to contribute to the pathology of many diseases associated with HHV-6.
There is an urgent need for more sensitive diagnostic assays and studies that can prove or disprove the important disease associations that have been suggested.

Conditions
- Encephalitis / Meningitis Overview
- Encephalitis in the Immunocompromised
- Encephalitis in the Immunocompetent
- Rhomboencephalitis
- Limbic Encephalitis
- Encephalomyelitis
- Amnesia
Endocrine Disorders
Hemophagocytic Conditions
- Hemophagocytic Syndrome/ Histiocytosis
- Drug Induced Hypersensitivity Syndrome (DIHS)
- Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS)
- Stevens-Johnson Syndrome (SJS)
- Bone marrow supression
- Colitis/diarrhea
- Delirium/CNS Dysfunction
- Encephalitis/Amnesia
- GVHD
- Hemophagocytic syndrome
- Hepatitis /Liver failure
- Pneumonitis
- Transplant Reactivation Overview