HHV-6 & Exanthemous Rash / Roseola

Yoshikawa 2009 Exanthem subitum-associated encephalitis: nationwide survey in Japan
Ward 2005 Human herpesviruses-6 and -7 each cause significant neurological morbidity in Britain and Ireland
Zerr 2005 A population-based study of primary human herpesvirus 6 infection

HHV-6 & Drug Induced Hypersensitivity Syndrome

Gentile 2010 Is the drug-induced hypersensitivity syndrome (DIHS) due to human herpesvirus 6 infection or to allergy-mediated viral reactivation? Report of a case and literature review
Hashizume 2009 Emergence of circulating monomyeloid precursors predicts reactivation of human herpesvirus-6 in drug-induced hypersensitivity syndrome
Tohyama 2007 Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome
Shiohara 2007 A Complex Interaction Between Drug Allergy and Viral Infection
Kano 2006 Hypogammaglobulinemia as an early sign of drug-induced hypersensitivity syndrome
Inaoka 2005 Innate immunity and hypersensitivity syndrome
Nakashima 2005 Drug-Induced Hypersensitivity Syndrome Associated with Transient Hypogammaglobulinaemia and Increase in Serum IgE Level
Kano 2004 Association Between Anticonvulsant Hypersensitivity Syndrome and Human Herpesvirus 6 Reactivation and Hypogammaglobulinemia

HHV-6 & Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS)

Picard 2010 Drug reaction with eosinophilia and systemic symptoms (DRESS): a multiorgan antiviral T cell response
Mardivirin 2009 Amoxicillin-induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro
Eshki 2009 Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure
Descamps 2001 Association of Human Herpesvirus 6 Infection With Drug Reaction With Eosinophilia and Systemic Symptoms

HHV-6 & Stevens-Johnson Syndrome (SJS)

Hirahara 2010 Differences in immunological alterations and underlying viral infections in two well-defined severe drug eruptions
Peppercorn 2010 High-Level Human Herpesvirus-6 Viremia Associated With Onset of Stevens-Johnson Syndrome: Report of Two Cases
Teraki 2010 Stevens–Johnson syndrome and toxic epidermal necrolysis due to anticonvulsants share certain clinical and laboratory features with drug-induced hypersensitivity syndrome, despite differences in cutaneous presentations

HHV-6 in Seizures & Status Epilepticus

Epstein 2011 The Role of Human Herpesvirus 6 and 7 in Febrile Status Epilepticus- FEBSTAT Study – L. Epstein
Laina 2010 Febrile seizures and primary human herpesvirus 6 infection
Ward 2005 Human herpesviruses-6 and -7 each cause significant neurological morbidity in Britain and Ireland
Yamashita 2005 HHV-6 and seizures

HHV-6 & Bone Marrow Suppression

Lagadinou 2010 Human herpesvirus 6-related pure red cell aplasia, secondary graft failure, and clinical severe suppression after allogeneic hematopoietic cell transplantation successfully treated with foscarnet
Hentrich 2005 Impact of human herpesvirus-6 after haematopoietic stem cell transplantation
Carrigan 1994 Bone Marrow Suppression by Human Herpesvirus-6: Comparisono f the A and B Variants of the Virus
Drobyski 1993 Human herpesvirus-6 (HHV-6) infection in allogeneic bone marrow transplant recipients: evidence of a marrow-suppressive role for HHV-6 in vivo

HHV-6 & Colitis

Revest 2011 Detection of HHV-6 in over a thousand samples: new types of infection revealed by an analysis of positive results
Pilmore 2009 Fatal human herpesvirus-6 infection after renal transplantation
Lamoth 2008 Case report: human herpesvirus 6 reactivation associated with colitis in a lung transplant recipient
Delbridge 2006 Colitis in a renal transplant patient with human herpesvirus-6 infection
Hentrich 2005 Impact of human herpesvirus-6 after haematopoietic stem cell transplantation

HHV-6 & Cognitive Dysfunction/Delirium

Zerr 2011 HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients
Provenzale 2010 Clinical and Imaging Findings Suggesting Human Herpesvirus 6 Encephalitis
Niebuhr 2008 Results from a hypothesis generating case-control study: herpes family viruses and schizophrenia among military personnel
Zerr 2006 Human herpesvirus 6 and central nervous system disease in hematopoietic cell transplantation
Zerr 2005 Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation
Leweke 2004 Antibodies to infectious agents in individuals with recent onset schizophrenia

HHV-6 & Amnesia

Seely 2007 Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6
Gorniak 2006 MR Imaging of Human Herpesvirus-6–Associated Encephalitis in 4 Patients with Anterograde Amnesia after Allogeneic Hematopoietic Stem-Cell Transplantation
Vissor 2005 Severe Amnesia due to HHV-6 Encephalitis after Allogenic Stem Cell Transplantation
MacLene 2002 Severe Amnesia Associated With Human Herpesvirus 6 Encephalitis After Bone Marrow Transplantation
Bollen 2001 Amnestic syndrome after lung transplantation by human herpes virus-6 encephalitis

HHV-6 & Multiple Sclerosis

Khaki 2011 Evaluation of viral antibodies in Iranian multiple sclerosis patients
Vandenbroeck 2011 Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection
Garcia-Montojo 2011 Human herpesvirus 6 and effectiveness of interferon beta 1b in multiple sclerosis patients
Behzad-Behbahani 2009 Human herpesvirus-6 viral load and antibody titer in serum samples of patients with multiple sclerosis
Ahram 2009 Association between human herpesvirus 6 and occurrence of multiple sclerosis among Jordanian patients
Alvarez-Lafuente 2008 Herpesviruses and human endogenous retroviral sequences in the cerebrospinal fluid of multiple sclerosis patients
Alvarez-Lafuente 2006 Clinical parameters and HHV-6 active replication in relapsing-remitting multiple sclerosis patients
Martínez 2007 Environment–gene interaction in multiple sclerosis: Human herpesvirus 6 and MHC2TA
Hollsberg 2005 Presence of Epstein–Barr virus and human herpesvirus 6B DNA in multiple sclerosis patients: associations with disease activity
Chapenko 2003 Correlation Between HHV-6 Reactivation and Multiple Sclerosis Disease Activity
Goodman 2003 Human herpesvirus 6 genome and antigen in acute multiple sclerosis lesions
Berti 2002 Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) exacerbations and correlation with parameters of MS disease progression
Ablashi 1998 Human Herpesvirus-6 (HHV-6) infection in multiple sclerosis: a preliminary report
Soldan 1997 Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA
Challoner 1995 Plaque-associated expression of human herpesvirus 6 in multiple sclerosis

HHV-6 & Rhomboencephalitis

Crawford 2007 Human Herpesvirus 6 Rhombencephalitis in Immunocompetent Children
Ohsaka 2006 Acute necrotizing encephalopathy associated with human herpesvirus-6 infection

HHV-6 in Chronic Fatigue Syndrome

Komaroff 2006 Is human herpesvirus-6 a trigger for chronic fatigue syndrome?
Chapenko 2006 Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome
Kogelnik 2006 Use of valganciclovir in patients with elevated antibody titers against Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) who were experiencing central nervous system dysfunction including long-standing fatigue
Ablashi 2000 Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients
Di Luca 1995 Human herpesvirus 6 and human herpesvirus 7 in chronic fatigue syndrome
Yalcin 1994 Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome
Buckwald 1992 A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection

HHV-6 & Cancer

Lacroix 2010 Involvement of human herpesvirus-6 variant B in classic Hodgkin’s lymphoma via DR7 oncoprotein
Crawford 2009 Detection of human herpesvirus-6 variants in pediatric brain tumors: Association of viral antigen in low grade gliomas
Crawford 2009 Detection of human herpesvirus-6 in adult central nervous system tumors: predominance of early and late viral antigens in glial tumors
Broccolo 2008 Frequency and clinical significance of human beta-herpesviruses in cervical samples from Italian women
Lacroix 2007 HHV-6 and EBV DNA Quantitation in Lymph Nodes of 86 Patients with Hodgkin’s Lymphoma
Yadav 1996 HHV-6 antigen and viral DNA detected in cervical cells from archived tissue using histochemical staining and hybridization
Chen 1994 Detection of Human Herpesvirus 6 and Human Papillomavirus 16 in Cervical Carcinoma

HHV-6 & Lung disease

Costa 2010 Herpesviruses detection by quantitative real-time polymerase chain reaction in bronchoalveolar lavage and transbronchial biopsy in lung transplant: viral infections and histopathological correlation
Bommer 2009 Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin’s disease: a case report
Buchbinder 2000 Human herpesvirus 6 is an important pathogen in infectious lung disease after allogeneic bone marrow transplantation
Cone 1996 Coinfection with human herpesvirus 6 variants A and B in lung tissue
Hammerling 1996 Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis

HHV-6 & Immune suppression

Li 2011 Human Herpesvirus 6 Suppresses T Cell Proliferation through Induction of Cell Cycle Arrest in Infected Cells in the G2/M Phase
Shirai 2009 Hypogammaglobulinemia with a clinical course similar to that of drug-induced hypersensitivity syndrome
Cermelli 2006 Human herpesvirus-6 dysregulates monocyte-mediated anticryptococcal defences
Wang 2006 Human herpesvirus-6-specific interleukin 10-producing CD4 T cells suppress the CD4 T-cell response in infected individuals
Nakashima 2006 Drug-Induced Hypersensitivity Syndrome Associated with Transient Hypogammaglobulinaemia and Increase in Serum IgE Level
Kumagai 2006 Time Course Characteristics of Human Herpesvirus 6 Specific Cellular Immune Response and Natural Killer Cell Activity in Patients With Exanthema Subitum
Niiya 2006 Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells
Lusso 2006 HHV-6 and the immune system: mechanisms of immunomodulation and viral escape
Smith 2005 Viral replication-independent blockade of dendritic cell maturation and interleukin-12 production by human herpesvirus 6
Kano 2004 Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia
Aihira 2003 Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction
Grivel 2003 Pathogenic Effects of Human Herpesvirus 6 in Human Lymphoid Tissue Ex Vivo
Boeckh 2003 Immunosuppressive Effects of Beta-herpesviruses
Smith 2003 Selective suppression of IL-12 production by human herpesvirus 6
Isomura 2003 Interaction of Human Herpesvirus 6 With Human CD34 Positive Cells

Encephalitis in the Immunocompetent

Olli-Lähdesmäki 2010 High-dose ganciclovir in HHV-6 encephalitis of an immunocompetent child
Yao 2009 Detection of Human Herpesvirus-6 in Cerebrospinal Fluid of Patients with Encephalitis
Yoshikawa 2009 Exanthem Subitum-Associated Encephalitis: Nationwide Survey in Japan
Trabue 2008 Case report and literature review: HHV-6-associated meningoencephalitis in an immunocompetent adult
Troy 2008 Severe encephalomyelitis in an immunocompetent adult with chromosomally integrated human herpesvirus 6 and clinical response to treatment with foscarnet plus ganciclovir
Gewurz 2008 Human herpesvirus 6 encephalitis
Sawada 2007 An adult case of relapsing human herpesvirus-6 encephalitis
Birnbaum 2005 Severe meningoencephalitis caused by human herpesvirus 6 type B in an immunocompetent woman treated with ganciclovir
Denes 2004 Successful treatment of human herpesvirus 6 encephalomyelitis in immunocompetent patient
Portolani 2002 Severe encephalopathy associated with reactivated human herpesvirus 6 in a six year-old immunocompetent child
Beovic 2001 Fatal human herpesvirus 6-associated multifocal meningoencephalitis in an adult female patient

Encephalitis in the Immunocompromised

Schmidt-Hieber 2011 Viral encephalitis after allogeneic stem cell transplantation: a rare complication with distinct characteristics of different causative agents
Kawamura 2011 Different characteristics of human herpesvirus 6 encephalitis between primary infection and viral reactivation
Ishiyama 2011 Preemptive therapy of human herpesvirus-6 encephalitis with foscarnet sodium for high-risk patients after hematopoietic SCT
Sakai 2011 Long-Term Outcome of Human Herpesvirus-6 Encephalitis after Allogeneic Stem Cell Transplantation
Zerr 2011 HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients
Ishiyama 2010 Preemptive therapy of human herpesvirus-6 encephalitis with foscarnet sodium for high-risk patients after hematopoietic SCT
Provenzale 2010 Clinical and Imaging Findings Suggesting Human Herpesvirus 6 Encephalitis
Ishiyama 2010 Preemptive therapy of human herpesvirus-6 encephalitis with foscarnet sodium for high-risk patients after hematopoietic SCT
Mori 2010 High incidence of human herpes virus 6-associated encephalitis/myelitis following a second unrelated cord blood transplantation
Cheng 2010 HHV-6 encephalitis in pediatric unrelated umbilical cord transplantation: a role for ganciclovir prophylaxis?
Vinnard 2010 A report of human herpesvirus 6-associated encephalitis in a solid organ transplant recipient and a review of previously published cases
Ogata 2008 Plasma HHV-6 viral load-guided preemptive therapy against HHV-6 encephalopathy after allogeneic stem cell transplantation: a prospective evaluation
Ichiyama 2008 Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection
Vu 2007 Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation

HHV-6 & Limbic encephalitis

Sauter 2009 Spectrum of imaging findings in immunocompromised patients with HHV-6 infection
Mata 2008 Human herpesvirus 6-associated limbic encephalitis in adult recipients of unrelated umbilical cord blood transplantation
Provenzale 2008 Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging
Seely 2007 Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6
Ito 2005 Limbic encephalitis associated with drug-induced hypersensitivity syndrome due to phenobarbital–a case report