How to Test a Uterine Biopsy For HHV-6A

Commercial labs that can test uterine biopsies for HHV-6 include Coppe Laboratories and ViracorIBT in the US as well as IKDT in Germany.

Coppe Laboratories (USA): Tissues can be sent frozen and shipped on dry ice for HHV-6A/B PCR DNA testing with the results being given as a ratio of HHV-6 genome to cellular genes ($385). Coppe asks that no buffer, water or saline be added to the sample and that it be shipped in a sterile tube/container. Code: 1111; (CPT 87532×2)

Alternatively, formalin fixed, paraffin embedded samples on glass slides can be sent for immunohistochemistry testing ($465 including interpretation).
Code: 2001 (CPT 88342)

ViracorIBT (USA): Quantitative PCR DNA testing for HHV-6. It does not differentiate between HHV-6A and HHV-6B.  They prefer frozen specimens with no added fluid, water or saline, shipped overnight with dry ice. No slides or paraffin embedded tissue accepted. Code: 6506

IKDT (Germany) Quantitative PCR DNA testing for HHV-6A/B . They can also test for mRNA to see if the virus is active. Ship tissue frozen overnight for DNA testing or send glass slides for immunohistochemistry analysis. For mRNA testing, send sample in RNALater solution.

See IKDT’s informative testing PDF at the following link: IKDT HHV-6 Testing Information

HHV-6A vs. HHV-6B.  Please note that Coppe and IKDT can differentiate HHV-6A from HHV-6B, but most labs do not have this capability. Only HHV-6A has been found in uterine biopsies of women with unexplained infertility (Marci 2016).