Sera drawn before vs. after onset of MS find seropositivity for HHV-6A more likely in MS.
Study pools data from nearly 30,000 people with MS.
Combination of viral load and presence of specific polymorphism in the TNF-α gene associated with major depression.
Role of several viruses, including HHV-6A/B, in stimulating low-grade neuroinflammation.
Patients with viral loads suggestive of iciHHV-6 had the greatest risk of developing demyelinating disease.
All cases found to be iciHHV-6 were assumed to be false positives.
Large study from UK Biobank finds that people seropositive for all of these four herpesviruses—HSV-1, HHV-6, HHV-7 and VZV—have greatly increased risk of developing dementia.
Data from 13,363 transplant patients underline the importance of preventing, diagnosing and treating viral reactivation.
Viral DNA and antigen found at higher levels in MTLE than in control brains.
Those with viral infections showed no difference in white or red blood cell counts or the protein and glucose levels.
Because of small number of ME/CFS subjects, the study is provocative rather than conclusive.
Biomarkers distinguish cases from healthy controls, but don’t all correlate with disease severity.
A growing number of case reports reveal reactivation similar to that seen after hematopoietic stem cell therapy. Could CAR-T cells be a source of lytic HHV-6?
Viral dUTPases are strong inducers of activin A and enhance T follicular helper-cell differentiation.
It remains unclear if there are lower levels of these antibodies in younger age groups.