• Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID

    Autoantibodies directed against neural targets have most predictive power.

  • iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

    iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

  • HHV-6 linked to miscarriage through Mendelian randomization studies

    The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.

  • Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

    Could HHV-6B infection exacerbate mitochondrial disease?

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Latest CNS Disease Articles

View Post

Herpesvirus “jumping genes” may contribute to Alzheimer’s disease

In All, Alzheimer's Disease, CNS Disease, Genes by Kristin LoomisApril 28, 2025

Transposable elements in aging brains were linked to herpesvirus RNA, predominantly HHV-6A, HHV-6B and HHV-7.

View Post

EBV and HHV-6 dUTPases explain 47% of the variance in autoantibody responses to myelin proteins in relapsing-remitting MS patients

In All, CNS Disease, Multiple Sclerosis by Kristin LoomisApril 28, 2025

Findings suggest that viral reactivation may trigger or sustain autoimmune responses in MS.

View Post

HHV-6 and HHV-7 frequently identified in the spinal fluid of patients with suspected encephalitis

In All, CNS Disease, Encephalitis & Encephalopathy by Kristin LoomisJanuary 7, 2025

Next-generation sequencing proves valuable for identifying CNS infections in the immunocompetent.

View Post

Could herpesvirus infection of endothelial cells be important in the pathophysiology of ME/CFS?

In All, CNS Disease, ME/CFS by Kristin LoomisJanuary 7, 2025

A recent review summarizes evidence that HHV-6 can cause endothelial dysfunction, which often is seen in both Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.

View Post

Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID

In All, CNS Disease, COVID-19 / HHV-6 Reactivation, ME/CFS by Kristin LoomisJanuary 7, 2025

Autoantibodies directed against neural targets have most predictive power.

View Post

Clinical evidence that infections, including with herpesviruses, increase risk for neurodegeneration

In All, CNS Disease by Kristin LoomisOctober 30, 2024

Epidemiologic research supports the provocative hypothesis.

View Post

Neuroimaging and proteomic evidence that infections, including with herpesviruses, increase risk for neurodegeneration

In All, CNS Disease by Kristin LoomisOctober 30, 2024

Objective laboratory measurements also support the provocative hypothesis.

View Post

Epidemiologic study links varicella-zoster virus reactivation to dementia years later

In All, CNS Disease by Kristin LoomisOctober 30, 2024

Observational longitudinal study finds correlation.

View Post

Shingrix shingles vaccination shown to reduce the risk of dementia

In All, CNS Disease by Kristin LoomisOctober 30, 2024

A large UK study compared those who took a shingles vaccine to those who took only flu or Tdap vaccines.

View Post

Patients hospitalized with SARS-CoV-2 are twice as likely to develop Alzheimer’s or memory problems

In All, CNS Disease, COVID by Kristin LoomisOctober 30, 2024

Study does not address whether reactivated herpesviruses might be playing a role in the increased neurologic sequelae.

View Post

A systematic review and meta-analysis confirms an association between HHV-6B reactivation and increased mortality after hematopoietic cell transplant

In All, CNS Disease, Encephalitis & Encephalopathy, Transplant Complications by Kristin LoomisSeptember 16, 2024

Randomized trials are warranted to evaluate if treating HHV-6B reactivation improves outcomes.

View Post

Large study from China identifies adverse outcomes associated with, and risk factors for, HHV-6 encephalitis in post-HSCT patients

In All, CNS Disease, Encephalitis & Encephalopathy, Transplant Complications by Kristin LoomisSeptember 16, 2024

Greatly increased risk of death, acute GVHD, transplant-associated microangiopathy found.

View Post

Febrile status epilepticus in infants with MRI-confirmed brain abnormalities linked to temporal lobe epilepsy later in life

In All, CNS Disease, Epilepsy and Seizures by Kristin LoomisSeptember 3, 2024

Surprisingly, although HHV-6B has been linked to febrile seizures, febrile status epilepticus and temporal lobe epilepsy, the report contains no mention of the virus.

View Post

Co-infection of HHV-6A and EBV results in a 6.7 fold increased risk of developing multiple sclerosis

In All, Autoimmune Disease, CNS Disease, Multiple Sclerosis by Kristin LoomisJune 24, 2024

The increased risk occurred only in adults who were infected with EBV after their teenage years, and had elevated EBNA-1 antibodies.

View Post

Antibodies to HHV-6 and HHV-6 dUTPase are strong predictors of Long COVID

In All, CNS Disease, ME/CFS by Kristin LoomisJuly 29, 2024

CRP and IgA antibodies to activin-A are also important predictors.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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