• Foscarnet prophylaxis improved engraftment and survival in cord blood transplant patients

    Six-month overall survival was 96% in the treated group compared to 72% in the untreated group.

  • Latent HHV-6B infection of astrocytes may increase the risk of depression by activating the HPA axis

    Japanese investigators show that a protein expressed by latent HHV-6B in astrocytes, results in an influx of extra-cellular calcium, triggering the onset of depression.

  • Mothers with iciHHV6 have an increased risk of spontaneous abortion

    27.6% of Japanese mothers with iciHHV6 had a spontaneous abortion compared to 14.8% of controls. iciHHV6 mothers were also 6.4X more likely to have two or more spontaneous abortions.

  • Significantly worse outcomes in critically ill hematology patients associated with HHV-6 infection.

    Two reports associate detectable HHV-6 DNA in body fluids with increased risk of mortality in patients being treated for hematologic malignancies.

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Latest CNS Disease Articles

View Post

Herpesvirus reactivation during alloHSCT associated with greatly increased mortality and expense

Data from 13,363 transplant patients underline the importance of preventing, diagnosing and treating viral reactivation.

View Post

Another report links HHV-6B nucleic acid and antigen to mesial temporal lobe epilepsy

Viral DNA and antigen found at higher levels in MTLE than in control brains.

View Post

HHV-6 DNA often found in cerebrospinal fluid in samples tested for meningitis

Those with viral infections showed no difference in white or red blood cell counts or the protein and glucose levels.

View Post

HHV-6 found in postmortem study of myalgic encephalomyelitis/chronic fatigue syndrome

Because of small number of ME/CFS subjects, the study is provocative rather than conclusive.

View Post

Increased HHV-6B viral load and levels of autonomic autoantibodies in ME/CFS

Biomarkers distinguish cases from healthy controls, but don’t all correlate with disease severity.

View Post

HHV-6 encephalitis following CAR-T cell therapy

A growing number of case reports reveal reactivation similar to that seen after hematopoietic stem cell therapy. Could CAR-T cells be a source of lytic HHV-6?

View Post

The dUTPases of HHV-6A and EBV may encourage autoimmunity in ME/CFS

Viral dUTPases are strong inducers of activin A and enhance T follicular helper-cell differentiation.

View Post

Elevated HHV-6 and EBV dUTPase antibody levels found in older populations

It remains unclear if there are lower levels of these antibodies in younger age groups.

View Post

Reactivation of latent herpesviruses and HERVS after mild COVID-19

Findings are accentuated in people with myalgic encephalomyelitis/chronic fatigue syndrome.

View Post

Differences in the cytopathic effect of HHV-6A and HHV-6B infection of neurons and glia

In vitro studies confirm that the two viruses infect different cell types, and generate different cytopathic effects, cytokine and growth factor responses.

View Post

HHV-6A promotes inflammation in astrocytoma cells by dysregulating autophagy

Infection increases ROS, induces ER stress and activates STAT3, NF-κB and mTOR pathways.

View Post

EBV and HHV-6 plasma viremia is infrequent at Day 7 during acute COVID-19

Other studies have suggested that reactivation of these viruses could theoretically contribute to a hyperinflammatory state or autoimmune disorders in acute COVID-19, but this study does not provide evidence of that.

View Post

Possible link between depression and HHV-6 infection in childhood

Serologic studies of several herpesviruses find that only HHV-6 may be linked to depression.

View Post

New seroepidemiological evidence that HHV-6 contributes to MS disease progression

Longitudinal study of people with a single initial episode of demyelination provides stronger evidence for HHV-6 than EBV in the pathogenesis of MS, but the evidence is not robust.

View Post

The presence of HHV-6 DNA in nasal swabs correlates with neurological symptoms in patients with severe COVID-19

40% of the patients with HHV-6 DNA had CNS symptoms, compared to 14.3% of the HHV-6 negative patients.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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