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Gene-expression network analysis points to HHV-6A as a key driver in upregulating genes leading to Alzheimer’s disease progression

In All, Alzheimer's Disease, CNS Disease, CNS Dysfunction by Kristin Loomis

Investigators at Mt Sinai used “big data” models to determine that the genes involved with fighting Alzheimer’s are the same ones that fight virus. They found HHV-6A and HHV-7 to be more abundant in Alzheimer’s brains, and singled out HHV6-A as a key modulator of the genes involved in amyloidosis and neuronal death.

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Latent HHV-6A may impair myelin repair in multiple sclerosis

In All, CNS Disease, Multiple Sclerosis by Kristin Loomis

A group at University of Rochester demonstrated that the HHV-6A latency gene, U94, inhibits migration of cells involved in myelin repair. Inefficient myelin repair is associated with progression MS, and the ability of HHV-6A to impede this process suggests that it could be involved in the progression of MS, and raises questions about the virus’s role in other chronic demyelinating diseases.

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HHV-6 identified in 12% of simple and 42% of complex pediatric febrile seizures

In All, CNS Disease, CNS Dysfunction, Epilepsy and Seizures by Kristin Loomis

Australian investigators studied 143 young children with febrile seizures for signs of viral infection and found that HHV-6 was the fifth most common virus after rhinovirus (22%), enterovirus (20%), adenovirus (21%) and influenza (13%). Overall, a virus was found in 71% of cases. Virus found in complex seizures was associated with HHV-6 (42%) or influenza (41%).

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Rapid point-of-care system screens for 14 encephalitis pathogens in one hour!

In All, CNS Disease, CNS Dysfunction, Encephalitis & Encephalopathy by Kristin Loomis

A new point-of-care assay from bioMérieux can simultaneously and rapidly detect 14 pathogens typically found in encephalitis. The machine is designed to be at the clinic or in the emergency room and can be operated by unskilled technicians. In a study of 1,560 immunocompetent patient samples, a total of 1.35% were positive for HHV-6, or about twice the expected rate of 0.8% found with the inherited chromosomally integrated HHV-6.

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HHV-6 found to cause 35% of CNS infections in allo-HSCT transplantation

In All, CNS Disease, Transplant Complications by Kristin Loomis

A retrospective analysis out of the Tokyo Metropolitan Cancer and Infectious Diseases Center reviewed 353 consecutive adult allogeneic hematopoietic stem cell transplant (allo-HSCT) cases and identified 17 cases of CNS infection post-transplant. As determined by PCR on cerebrospinal fluid, HHV-6 was found to be the causative agent in 6 cases, or 1.7% of all transplants.

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HHV-7 homolog found in the peripheral nerve ganglia of macaques

In All, Animal Models, CNS Disease by Kristin Loomis

Virologists led by Serge Barcy, PhD at the Seattle Children’s Research Institute and University of Washington have identified a homolog for HHV-7 in pigtail macaques They were surprised to learn that it could be detected in the peripheral nerve ganglia, and hope to use their new animal model to explore how HHV-7 might play a role in demyelinating diseases.