HHV-6 was found in 33% of adenoid and 45% of tonsil tissues, with the highest rates found in younger children.
The presence of HHV-6 and EBV DNA in nasal secretions correlates with the degree of adenoid hypertrophy in children.
A Swiss team studied 134 young children who were experiencing unidentified high fevers and were able to find at least one virus in 35% of those patients. The two biggest culprits were enterovirus (14%) and HHV-6 (11%).
Investigators at the National Cancer Institute found that HHV-6+ lymph nodes can be identified in biopsies from both lymphadenopathy and malignancies. They warn that failing to identify HHV-6 in these biopsies can lead to misdiagnosis in lymphoma cases.
Investigators at Yale University warn that hypersensitivity-associated HHV-6 lymphadenopathy can have the same presentation as lymphoma.
A group of Italian investigators have determined that a subset of patients with lymphadenopathy have active HHV-6B infections.
A new case report describes a case of HHV-6 acute lymphadenitis in an immunocompetent patient, and reviews several other case reports of this condition.