Whether HHV-6 has a causal role in leaky gut is not addressed.
HHV-6 & acute pediatric hepatitis of unknown cause: Japan’s experience
Adeno-associated virus (AAV) linked to Japanese cases, but whether HHV-6 was a cofactor is uncertain.
HHV-6 found to be possible etiologic agent in some cases of acute hepatitis of unknown origin
Israeli study of 20 pediatric cases occurring in 2021 found more evidence for HHV-6 than for other viruses, including AAV2 and SARS-CoV-2.
Centrilobular necroinflammation associated with pediatric HHV-6+ acute liver failure
Would early treatment with antiviral therapy prevent the need for a liver transplant?
Reactivated HHV-6, CMV, adenovirus and BK virus associated with increased mortality in pediatric sepsis
Odds of mortality were 2.6-3X higher in patients with detectable viral DNA; odds were even higher with multiple herpesviruses.
Antibodies to a protein specific to latent HHV-6B linked to ulcerative colitis flares
Patients with elevated levels of antibodies to novel biomarker SITH-1 were significantly more likely to have disease activity.
Breakthrough reactivation of HHV-6 occurs with liver transplantation in spite of valganciclovir preemptive therapy for CMV
High-grade HHV-6 viremia is independently associated with rejection of liver transplants within 12 months
Neonatal murine roseolovirus infection induces autoimmunity
Early infection interferes with normal thymocyte development and disrupts central tolerance resulting in autoimmune disease later in life. Only infection during this critical time period resulted in autoimmunity.
HHV-6 DNA in bile fluid correlates with higher mortality in liver transplant patients
Persistent HHV-6 infection in the liver is hard to detect from plasma samples and liver biopsies may miss spotty infections. Bile fluid may be the best method for detecting herpesviruses that impact the liver.
Stanford finds high levels of HHV-6 in the tissues of children with liver failure
A team at Stanford reported that 48% of young children with “liver failure of unknown etiology” had high viral loads of HHV-6 in their liver tissues. As a result, Stanford has now instituted routine evaluation for HHV-6 in all children who present with liver failure.
HHV-6 reactivation associated with unexplained fever and biliary atresia in pediatric liver transplant patients
A Japanese study found that unexplained fever and biliary atresia are associated with HHV-6B infection in pediatric transplant patients. 100% of seronegative infants developed a primary infection.
Deep sequencing analysis finds HHV-6, CMV and EBV in a subset of stomach and colon cancers
A team at University of Pittsburgh analyzed a large database of deep sequencing data from tumor and control tissues to look for viral sequences in 22 different cancers. They were surprised to find several herpesviruses in gastrointestinal cancers but not in control tissues.
HHV-6 acute liver failure in an immunocompetent child: case report
HHV-6 is rarely identified as the cause of liver dysfunction in immunocompetent children, in part because HHV-6 is not included in routine testing, and HHV-6 infections can be highly localized to the liver. In this case, an alert team in Arizona identified HHV-6 by needle biopsy.
HHV-6B reactivates first, proceeds to end organ disease faster in transplant patients
Investigators at Fred Hutch Cancer Research Center found that HHV-6B is the first DNA virus to reactivate at a median of 3 weeks, compared to CMV, EBV and Adenovirus at 5-6 weeks. HHV-6B also peaked rapidly, unlike other DNA viruses that took 3-6 weeks to reach peak viral load. HHV-6B reactivation resulted in increased mortality after 100 days.
HHV-6B induces telomeric hypomethylation, possibly facilitating integration
HHV-6B induces unique, region-specific DNA hypomethylation, and findings suggest that the epigenetic modification may facilitate HHV-6B integration.
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