Cytokine and chemokine responses were very similar in HHV-6B and HHV-7 infections. The results were starkly different for HHV-6A.
University of Washington’s Clinical Laboratory in the News
Keith Jerome and Alex Greninger’s virology lab at University of Washington was one of the first in the nation with a test for SARS CoV-2 and they are credited with helping to identify the first confirmed US case of the virus in January. Keith Jerome, MD, PhD, Director, and Alex Greninger, MD, PhD, Assistant Director of the University of Washington Virology Laboratory in Seattle. Greninger was featured in an interview in GQ, titled “The Infuriating Story of How the Government Stalled Coronavirus Testing” that he began developing the test early in January, when the sequence was first announced. Since then, he and his team have worked tirelessly to expand capacity in-house to diagnose more patients. A clip of a PBS …
Comprehensive annotations of HHV-6A/B reveal novel genomic features
Hundreds of new open reading frames were identified in a comprehensive Weizman Institute study that has generated a complete, unbiased atlas of the HHV-6A/B proteome.
Spontaneous gene expression in iciHHV-6A/B individuals leads to increased HHV-6 IE-1A/B and CMV antibody response; higher levels of RNA were found in iciHHV-6A brains
A comprehensive study of DNA and RNA-Seq data demonstrated in vivo gene expression in many iciHHV-6 tissues, with strong expression of IE-1 and matching elevated antibody response in iciHHV-6 individuals compared to controls.
Weizman Institute study reveals a comprehensive annotation of HHV-6A/B, providing a rich resource for future studies
Israeli scientists have identified hundreds of new open reading frames, generating an unbiased atlas of the HHV-6 proteome. They also identified three highly abundant long non-coding RNAs.
Differential gene expression pattern shared in herpesviruses, Alzheimer’s & Parkinson’s patients
Researchers from GlaxoSmithKline found a significant overlap in differentially expressed genes shared by those with herpesvirus infections, Alzheimer’s and Parkinson’s. On the other hand, there was no significant overlap between herpesviruses and Type 2 diabetes or Huntington’s disease.
Yasuko Mori awarded Lifetime Achievement Award
Yasuko Mori, PhD, Professor of Clinical Virology at the Kobe University Graduate School of Medicine was awarded the HHV-6 Foundation’s Dharam Ablashi Lifetime Achievement Award at the 11th International Conference on HHV-6 & 7.
HHV-6 latency gene U94 has anti-cancer effects in triple-negative breast cancer cells
The U94 “latency” gene of HHV-6, interferes with breast cancer proliferation and potentiates chemotherapy.
Berberine is as effective as ganciclovir in controlling CMV, and targets IE -2 protein transactivating activity
A Chinese medicine that has been used for thousands of years, berberine inhibits replication of CMV at micromolar levels in vitro. It was also effective against drug resistant strains of CMV, as well against murine cytomegalovirus.
Alexander Greninger awarded the Koichi Yamanishi Young Investigator Award for Basic Science
Alex Greninger, PhD, was awarded the Junior Investigator award for Basic Science at the 11th international HHV-6 & 7 Conference in Quebec City, Canada.
Xiaofeng Zhou awardeed Young Investigator Award for Clinical Research
Xiafeng Zhou was awarded the Young Investigator Award for Clinical Research at the 11th International HHV-6 & 7 Conference in Quebec City, Canada.
An elevated CD134/CD4+ ratio before conditioning results in a 10 fold increased risk of HHV-6B reactivation
A prospective study of allogenic stem cell transplant patients in Japan suggests that the percentage of CD134+ T cells could be used to predict which patients are vulnerable to HHV-6 reactivation. The authors propose that further investigation into the effect of elevated CD134+ T cells pre-transplant is warranted.
Mori lab identifies a vaccine and immunotherapy target for HHV6-B
Rational vaccine design requires understanding details of protective immunity against each virus. Yasuko Mori and associates from Japan have now identified CD4+ and H-2Kd restricted CD8+ T-cell epitopes essential for HHV-6B viral entry, opening new possibilities for vaccines and immunotherapy.
Breakthrough on therapeutic HHV-6B neutralizing antibodies
Yasuko Mori and colleagues were successful in humanizing two neutralizing monoclonal antibodies to HHV-6B. The chimeric antibodies performed well enough to show promise for therapeutic use.
HHV-6 DR7 found to promote glioma development and progression
A Chinese group found HHV-6 direct repeat 7 in 48% of glioma tumors. Furthermore, they determined that DR7 overexpression could promote glioma cell migration, invasion and angiogenesis. Expression profiles showed that DR7 created an inflammatory microenvironment that enhanced degradation of the extracellular matrix.