HHV-6B U20 protein inhibits NK cell attacks on virally-infected cells.
MicroRNA expression patterns suggest that HHV-6 may play a role in triggering systemic sclerosis
Expression pattern of several miRNAs in SS tissue parallels the pattern generated when dermal fibroblasts and endothelial cells are infected by HHV-6A and CMV.
Could a specific polymorphism in HHV-6B partially explain the heritability of major depression?
Individuals carrying this polymorphism had a five-fold increased risk of depression and were more likely to have a family member with major depression.
HHV-6B IE1 inhibits DNA damage signaling pathway leading to genomic instability
Results suggest a possible link between genomic instability and iciHHV-6 associated disease.
Synergistic role of HHV-6A U37 and heat shock proteins in viral replication
Findings provide important insights that may reveal potential targets for antiviral therapy.
Translation of HHV-6B U20 gene product characterized
Findings suggest role in evading host immune defenses.
COVID-19 patients with HHV-6 DNA and CNS symptoms showed increased expression of miR-155
Both HHV-6 and specific microRNAs may correlate with neurological symptoms in COVID-19.
Single cell transcriptomics of iciHHV-6 cell lines immortalized by EBV infection
Transcription of HHV-6 genes was rare, but occurred most often in cells with the highest levels of EBV transcription.
Using CRISPR to excise integrated HHV-6A from latently infected cells and iciHHV6 patient cell lines, in vitro
Advance may aid the study of integration and excision and might ultimately have clinical application.
Differentially expressed HHV-6A/B and HHV-7 genes may have prognostic value in gliomas
Unclear if viral gene expression signature confers prognostic information that is independent of host cell gene expression signatures.
Two HHV-6 genes may contribute to pathogenesis of autoimmune thyroiditis
Genes U12 and U51 encode homologues of human G-protein-coupled receptors, and are potential triggers of autoimmunity.
Does inherited chromosomal integration of HHV-6 at 9q increase the risk of malignancy?
A large study of iciHHV-6 integration sites found integration at 9q more common in hematologic malignancies—but the study lacked power to draw firm conclusions.
Development of highly sensitive technique for detecting viral DNA sequences in cell-free plasma
Isolating DNA fragments less than 120 base pairs enriches for viral vs. cellular DNA.
G-1082A polymorphism of IL-10 may protect against HHV-6/EBV adenoid hypertrophy
The presence of HHV-6 and EBV DNA in nasal secretions correlates with the degree of adenoid hypertrophy in children.
HHV-6A U14 protein and NFκB activate each other
The late protein U14 of HHV-6A can induce the pro-inflammatory transcription factor NFκB, and NFκB, in turn, can encourage the replication of HHV-6A.
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