• Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID

    Autoantibodies directed against neural targets have most predictive power.

  • iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

    iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

  • HHV-6 linked to miscarriage through Mendelian randomization studies

    The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.

  • Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

    Could HHV-6B infection exacerbate mitochondrial disease?

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Latest Genes Articles

View Post

Herpesvirus “jumping genes” may contribute to Alzheimer’s disease

In All, Alzheimer's Disease, CNS Disease, Genes by Kristin LoomisApril 28, 2025

Transposable elements in aging brains were linked to herpesvirus RNA, predominantly HHV-6A, HHV-6B and HHV-7.

View Post

Extracellular viral microRNAs as novel biomarkers to differentiate active from latent infections

In All, Genes, Transplant Complications by Kristin LoomisApril 28, 2025

Short non-coding RNA’s provide cell-free, activity-specific viral signatures.

View Post

High levels of herpesviruses found in patients suspected of bloodstream infections using metagenomic NGS sequencing of cfDNA

In All, Genes, Transplant Complications by Kristin LoomisApril 28, 2025

EBV was found in 28.6%; HHV-6 and CMV were found in 18.4% of cases.

View Post

HHV-6B Ribonucleotide Reductase Sequesters NF-κB Subunit p65 to Inhibit Innate Immune Responses

In All, Genes, Immunity & Immunotherapy by Kristin LoomisApril 28, 2025

This study helps explain how roseoloviruses maintain persistent infection.

View Post

A variety of techniques greatly increase the efficiency of HHV-6A reconstitution and replication using BACs

In All, Genes by Kristin LoomisJanuary 7, 2025

Improving efficiency of reconstitution may aid in study of HHV-6 biology.

View Post

Telomeric repeats (TMRs) important for Marek’s Disease virus live vaccine efficacy

In All, Animal Models, ciHHV-6, Genes, iciHHV-6 by Kristin LoomisNovember 22, 2024

Chromosomal integration and maintenance, as well as vaccine efficacy, severely impaired in the absence of TMRs.

View Post

Single-cell RNA sequencing was used to determine the tropism of MRV in the thymus and how central tolerance is disrupted

In All, Animal Models, Autoimmune Disease, Genes by Kristin LoomisOctober 30, 2024

A new cell culture model for MRV could offer insights on the development of autoimmunity after neonatal infection.

View Post

New mechanism identified by which HHV-6B evades NK cell recognition

In All, Genes, Immunity & Immunotherapy by Kristin LoomisJuly 29, 2024

HHV-6B U20 protein inhibits NK cell attacks on virally-infected cells.

View Post

MicroRNA expression patterns suggest that HHV-6 may play a role in triggering systemic sclerosis

In All, Autoimmune Disease, Genes, Rash & Roseola by Kristin LoomisJuly 29, 2024

Expression pattern of several miRNAs in SS tissue parallels the pattern generated when dermal fibroblasts and endothelial cells are infected by HHV-6A and CMV.

View Post

Could a specific polymorphism in HHV-6B partially explain the heritability of major depression?

In All, CNS Disease, Genes by Kristin LoomisApril 18, 2024

Individuals carrying this polymorphism had a five-fold increased risk of depression and were more likely to have a family member with major depression.

View Post

HHV-6B IE1 inhibits DNA damage signaling pathway leading to genomic instability

In All, ciHHV-6, Genes by Kristin LoomisMarch 4, 2024

Results suggest a possible link between genomic instability and iciHHV-6 associated disease.

View Post

Synergistic role of HHV-6A U37 and heat shock proteins in viral replication

In All, Genes by Kristin LoomisMarch 4, 2024

Findings provide important insights that may reveal potential targets for antiviral therapy.

View Post

Translation of HHV-6B U20 gene product characterized

In All, Genes by Kristin LoomisSeptember 28, 2023

Findings suggest role in evading host immune defenses.

View Post

COVID-19 patients with HHV-6 DNA and CNS symptoms showed increased expression of miR-155

In All, COVID, COVID-19 / HHV-6 Reactivation, Genes by Kristin LoomisAugust 29, 2023

Both HHV-6 and specific microRNAs may correlate with neurological symptoms in COVID-19.

View Post

Single cell transcriptomics of iciHHV-6 cell lines immortalized by EBV infection

In All, Genes, iciHHV-6 by Kristin LoomisJuly 3, 2023

Transcription of HHV-6 genes was rare, but occurred most often in cells with the highest levels of EBV transcription.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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