Transposable elements in aging brains were linked to herpesvirus RNA, predominantly HHV-6A, HHV-6B and HHV-7.
Extracellular viral microRNAs as novel biomarkers to differentiate active from latent infections
Short non-coding RNA’s provide cell-free, activity-specific viral signatures.
High levels of herpesviruses found in patients suspected of bloodstream infections using metagenomic NGS sequencing of cfDNA
EBV was found in 28.6%; HHV-6 and CMV were found in 18.4% of cases.
HHV-6B Ribonucleotide Reductase Sequesters NF-κB Subunit p65 to Inhibit Innate Immune Responses
This study helps explain how roseoloviruses maintain persistent infection.
A variety of techniques greatly increase the efficiency of HHV-6A reconstitution and replication using BACs
Improving efficiency of reconstitution may aid in study of HHV-6 biology.
Telomeric repeats (TMRs) important for Marek’s Disease virus live vaccine efficacy
Chromosomal integration and maintenance, as well as vaccine efficacy, severely impaired in the absence of TMRs.
Single-cell RNA sequencing was used to determine the tropism of MRV in the thymus and how central tolerance is disrupted
A new cell culture model for MRV could offer insights on the development of autoimmunity after neonatal infection.
New mechanism identified by which HHV-6B evades NK cell recognition
HHV-6B U20 protein inhibits NK cell attacks on virally-infected cells.
MicroRNA expression patterns suggest that HHV-6 may play a role in triggering systemic sclerosis
Expression pattern of several miRNAs in SS tissue parallels the pattern generated when dermal fibroblasts and endothelial cells are infected by HHV-6A and CMV.
Could a specific polymorphism in HHV-6B partially explain the heritability of major depression?
Individuals carrying this polymorphism had a five-fold increased risk of depression and were more likely to have a family member with major depression.
HHV-6B IE1 inhibits DNA damage signaling pathway leading to genomic instability
Results suggest a possible link between genomic instability and iciHHV-6 associated disease.
Synergistic role of HHV-6A U37 and heat shock proteins in viral replication
Findings provide important insights that may reveal potential targets for antiviral therapy.
Translation of HHV-6B U20 gene product characterized
Findings suggest role in evading host immune defenses.
COVID-19 patients with HHV-6 DNA and CNS symptoms showed increased expression of miR-155
Both HHV-6 and specific microRNAs may correlate with neurological symptoms in COVID-19.
Single cell transcriptomics of iciHHV-6 cell lines immortalized by EBV infection
Transcription of HHV-6 genes was rare, but occurred most often in cells with the highest levels of EBV transcription.