• 12th International Conference on HHV-6 & 7 Announced

    The 12th International Conference on HHV-6 & 7 will convene in Japan at the Himeji Culture and Convention Center in March 2025.

  • Short-course foscarnet at an early stage may suppress HHV-6 reactivation following allogenic HCT

    Observational study suggests that an early one-week treatment at the first sign of viral reactivation may achieve clinical benefits and avoid antiviral toxicity.

  • Herpesvirus Reactivation Common in Severe COVID-19

    HHV-6 was the most common herpesvirus found when tested in nasal swabs, but EBV was the most common in plasma.

  • High levels of HHV-6A DNA found in blood of 52% of kidney transplant patients

    HHV-6A was the most common virus identified, but was not linked to worse outcomes compared to other viral infections.

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Latest Genes Articles

View Post

Translation of HHV-6B U20 gene product characterized

Findings suggest role in evading host immune defenses.

View Post

COVID-19 patients with HHV-6 DNA and CNS symptoms showed increased expression of miR-155

Both HHV-6 and specific microRNAs may correlate with neurological symptoms in COVID-19.

View Post

Single cell transcriptomics of iciHHV-6 cell lines immortalized by EBV infection

Transcription of HHV-6 genes was rare, but occurred most often in cells with the highest levels of EBV transcription.

View Post

Using CRISPR to excise integrated HHV-6A from latently infected cells and iciHHV6 patient cell lines, in vitro

Advance may aid the study of integration and excision and might ultimately have clinical application.

View Post

Differentially expressed HHV-6A/B and HHV-7 genes may have prognostic value in gliomas

Unclear if viral gene expression signature confers prognostic information that is independent of host cell gene expression signatures.

View Post

Two HHV-6 genes may contribute to pathogenesis of autoimmune thyroiditis

Genes U12 and U51 encode homologues of human G-protein-coupled receptors, and are potential triggers of autoimmunity.

View Post

Does inherited chromosomal integration of HHV-6 at 9q increase the risk of malignancy?

A large study of iciHHV-6 integration sites found integration at 9q more common in hematologic malignancies—but the study lacked power to draw firm conclusions.

View Post

Development of highly sensitive technique for detecting viral DNA sequences in cell-free plasma

Isolating DNA fragments less than 120 base pairs enriches for viral vs. cellular DNA.

View Post

G-1082A polymorphism of IL-10 may protect against HHV-6/EBV adenoid hypertrophy

The presence of HHV-6 and EBV DNA in nasal secretions correlates with the degree of adenoid hypertrophy in children.

View Post

HHV-6A U14 protein and NFκB activate each other

The late protein U14 of HHV-6A can induce the pro-inflammatory transcription factor NFκB, and NFκB, in turn, can encourage the replication of HHV-6A.

View Post

Different isoforms of CD46 affect infectivity and replication of HHV-6A and HHV-6B

While CD134 remains the more important receptor for HHV-6B, HHV-6B can use the CD46 receptor when a T cell has the C1 isoform of CD46.

View Post

HHV-6B may enter cells that don’t express CD134 via the nectin-2 receptor

If confirmed, finding could explain ability of HHV-6B to infect salivary, liver and neural cells.

View Post

Modulation of HHV-6B and HHV-6A infection and gene expression by CD9

The tetraspanin CD9 promotes CD46-dependent cellular infection by HHV-6A and impairs CD46-independent infection by HHV-6B.

View Post

The U20 and U21 genes of HHV-6A downregulate NK cell attack

U20/21 genes may help HHV-6A evade immune response

View Post

4C-seq genomic methodology used to examine HHV-6A integration sites

Chromatin interactions help silence transcription of HHV-6A genes following integration

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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