• Foscarnet prophylaxis improved engraftment and survival in cord blood transplant patients

    Six-month overall survival was 96% in the treated group compared to 72% in the untreated group.

  • Latent HHV-6B infection of astrocytes may increase the risk of depression by activating the HPA axis

    Japanese investigators show that a protein expressed by latent HHV-6B in astrocytes, results in an influx of extra-cellular calcium, triggering the onset of depression.

  • Mothers with iciHHV6 have an increased risk of spontaneous abortion

    27.6% of Japanese mothers with iciHHV6 had a spontaneous abortion compared to 14.8% of controls. iciHHV6 mothers were also 6.4X more likely to have two or more spontaneous abortions.

  • Significantly worse outcomes in critically ill hematology patients associated with HHV-6 infection.

    Two reports associate detectable HHV-6 DNA in body fluids with increased risk of mortality in patients being treated for hematologic malignancies.

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Latest Genes Articles

View Post

Two HHV-6 genes may contribute to pathogenesis of autoimmune thyroiditis

Genes U12 and U51 encode homologues of human G-protein-coupled receptors, and are potential triggers of autoimmunity.

View Post

Does inherited chromosomal integration of HHV-6 at 9q increase the risk of malignancy?

A large study of iciHHV-6 integration sites found integration at 9q more common in hematologic malignancies—but the study lacked power to draw firm conclusions.

View Post

Development of highly sensitive technique for detecting viral DNA sequences in cell-free plasma

Isolating DNA fragments less than 120 base pairs enriches for viral vs. cellular DNA.

View Post

G-1082A polymorphism of IL-10 may protect against HHV-6/EBV adenoid hypertrophy

The presence of HHV-6 and EBV DNA in nasal secretions correlates with the degree of adenoid hypertrophy in children.

View Post

HHV-6A U14 protein and NFκB activate each other

The late protein U14 of HHV-6A can induce the pro-inflammatory transcription factor NFκB, and NFκB, in turn, can encourage the replication of HHV-6A.

View Post

Different isoforms of CD46 affect infectivity and replication of HHV-6A and HHV-6B

While CD134 remains the more important receptor for HHV-6B, HHV-6B can use the CD46 receptor when a T cell has the C1 isoform of CD46.

View Post

HHV-6B may enter cells that don’t express CD134 via the nectin-2 receptor

If confirmed, finding could explain ability of HHV-6B to infect salivary, liver and neural cells.

View Post

Modulation of HHV-6B and HHV-6A infection and gene expression by CD9

The tetraspanin CD9 promotes CD46-dependent cellular infection by HHV-6A and impairs CD46-independent infection by HHV-6B.

View Post

The U20 and U21 genes of HHV-6A downregulate NK cell attack

U20/21 genes may help HHV-6A evade immune response

View Post

4C-seq genomic methodology used to examine HHV-6A integration sites

Chromatin interactions help silence transcription of HHV-6A genes following integration

View Post

Updated mapping and proposed new annotation of the HHV-6B transcriptome

An analysis of the kinetics of gene expression during infection of human Molt-3 T-cells agrees with previous studies, but also demonstrates unique findings.

View Post

A large scale whole genome sequencing study sheds light on HHV-6 integration events

Investigators at the Riken Institute in Japan developed new computational methods to detect virus induced structural variants in the human genome

View Post

A comprehensive review of the role and potential functions HHV-6A/B U94

The review covers the role the U94 gene product plays in the virus’s life cycle, replication, and latency, as well as in the immune response.

View Post

iciHHV-6 may modulate human gene expression

A Japanese group found that ciHHV6 genes encoding for immunoglobulins were decreased in ciHHV6 individuals, possibly modulating immune responses.

View Post

Spontaneous gene expression in iciHHV-6A/B individuals leads to increased HHV-6 IE-1A/B and CMV antibody response; higher levels of RNA were found in iciHHV-6A brains

A comprehensive study of DNA and RNA-Seq data demonstrated in vivo gene expression in many iciHHV-6 tissues, with strong expression of IE-1 and matching elevated antibody response in iciHHV-6 individuals compared to controls.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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