Read why some believe that “endogenous HHV-6” is a better term than inherited chromosomally integrated HHV-6, and sign on to their open letter if you agree.
Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA
Could HHV-6B infection exacerbate mitochondrial disease?
iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations
iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.
Telomeric repeats (TMRs) important for Marek’s Disease virus live vaccine efficacy
Chromosomal integration and maintenance, as well as vaccine efficacy, severely impaired in the absence of TMRs.
A remarkably low prevalence of iciHHV-6 (0- 0.24%) reported in two Finnish studies
Out of 1,276 pregnancies all three iciHHV-6 cases involved preeclampsia or growth restriction.
Reactivation of a transplant recipient’s iciHHV-6B resulted in an active infection of his donated liver
Investigators from the University of Helsinki used highly sophisticated techniques to establish that the donor’s integrated virus reactivated and then infected the graft. This thorough investigation highlights the potential pathological impact of iciHHV-6B in transplantation.
Biofire multiplex PCR assay accurately detects HHV-6 meningitis/encephalitis in immunocompromised adults
Utility of the assay in immunocompetent patients requires further study.
Single cell transcriptomics of iciHHV-6 cell lines immortalized by EBV infection
Transcription of HHV-6 genes was rare, but occurred most often in cells with the highest levels of EBV transcription.
4C-seq genomic methodology used to examine HHV-6A integration sites
Chromatin interactions help silence transcription of HHV-6A genes following integration
A large scale whole genome sequencing study sheds light on HHV-6 integration events
Investigators at the Riken Institute in Japan developed new computational methods to detect virus induced structural variants in the human genome