• Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID

    Autoantibodies directed against neural targets have most predictive power.

  • iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

    iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

  • HHV-6 linked to miscarriage through Mendelian randomization studies

    The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.

  • Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

    Could HHV-6B infection exacerbate mitochondrial disease?

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Latest iciHHV-6 Articles

View Post

Leading HHV-6 investigators encourage using new name for iciHHV-6

In All, ciHHV-6, iciHHV-6 by Kristin LoomisApril 28, 2025

Read why some believe that “endogenous HHV-6” is a better term than inherited chromosomally integrated HHV-6, and sign on to their open letter if you agree.

View Post

Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

In All, iciHHV-6, Kidney Disease, ME/CFS by Kristin LoomisMarch 2, 2025

Could HHV-6B infection exacerbate mitochondrial disease?

View Post

iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

In All, Autoimmune Disease, iciHHV-6 by Kristin LoomisFebruary 5, 2025

iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

View Post

Telomeric repeats (TMRs) important for Marek’s Disease virus live vaccine efficacy

In All, Animal Models, ciHHV-6, Genes, iciHHV-6 by Kristin LoomisNovember 22, 2024

Chromosomal integration and maintenance, as well as vaccine efficacy, severely impaired in the absence of TMRs.

View Post

A remarkably low prevalence of iciHHV-6 (0- 0.24%) reported in two Finnish studies

In All, ciHHV-6, iciHHV-6, Infertility & Miscarriage by Kristin LoomisNovember 22, 2024

Out of 1,276 pregnancies all three iciHHV-6 cases involved preeclampsia or growth restriction.

View Post

Reactivation of a transplant recipient’s iciHHV-6B resulted in an active infection of his donated liver

In All, ciHHV-6, iciHHV-6, Transplant Complications by Kristin LoomisJuly 5, 2024

Investigators from the University of Helsinki used highly sophisticated techniques to establish that the donor’s integrated virus reactivated and then infected the graft. This thorough investigation highlights the potential pathological impact of iciHHV-6B in transplantation.

View Post

Biofire multiplex PCR assay accurately detects HHV-6 meningitis/encephalitis in immunocompromised adults

In All, CNS Disease, iciHHV-6, Transplant Complications by Kristin LoomisJune 25, 2024

Utility of the assay in immunocompetent patients requires further study.

View Post

Single cell transcriptomics of iciHHV-6 cell lines immortalized by EBV infection

In All, Genes, iciHHV-6 by Kristin LoomisJuly 3, 2023

Transcription of HHV-6 genes was rare, but occurred most often in cells with the highest levels of EBV transcription.

View Post

4C-seq genomic methodology used to examine HHV-6A integration sites

In All, Genes, iciHHV-6, Latest Scientific News by Kristin LoomisMay 20, 2022

Chromatin interactions help silence transcription of HHV-6A genes following integration

View Post

A large scale whole genome sequencing study sheds light on HHV-6 integration events

In All, ciHHV-6, Genes, iciHHV-6, Latest Scientific News by Kristin LoomisApril 4, 2022

Investigators at the Riken Institute in Japan developed new computational methods to detect virus induced structural variants in the human genome

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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