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Inherited ciHHV-6 increases risk of developing acute GVHD and CMV in transplant patients.

In All, Cancer, ciHHV-6, GVHD by Kristin Loomis

A higher prevalence of inherited virus was found in patients

Investigators at Fred Hutchinson Cancer Center determined that transplant patients with inherited ciHHV-6 were twice as likely to develop acute graft vs host disease and three times more likely to develop high level CMV viremia. Transplant patients were also significantly more likely to have inherited ciHHV-6 than donors.

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Does the high level of U94 in iciHHV-6 contribute to abnormal ‘marker’ chromosomes and cancer?

In All, Cancer, ciHHV-6 by Kristin Loomis

Investigators from the University of Ferrara, Italy have found evidence suggesting that high levels of U94 in ciHHV6 may predispose to the formation of marker chromosomes. A patient with diffuse large B-cell lymphoma positive for inherited chromosomally integrated HHV-6A and HHV-6A was also found in a marker chromosome, an abnormal piece of chromosome that is seen in some leukemia and lymphomas.

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Surprise finding : HHV-6 telomeric repeats are crucial for HHV-6 integration

In All, ciHHV-6, Latest Scientific News, Molecular Biology by Kristin Loomis

When the research team led by Benedikt Kaufer attempted to shed light on the mechanism behind HHV-6 integration, they were suprised to find telomeric repeats were critical to the integration process. Since the U94 gene shares homology and biological properties with the adenovirus Rep68 gene responsible for viral integration into human chromosomes, U94 was considered the most likely candidate to mediate HHV-6 integration.

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Superinfection of HHV-6A in ciHHV6A patients with recurrent cardiac disease: a full genome analysis

In All, ciHHV-6, Genes & Proteins, Heart Disease, Latest Scientific News by Kristin Loomis

A group led by Ursula Gompels from the London School of Hygiene & Tropical Medicine, University of London, did next generation sequencing on three ciHHV6A cardiac patients and found superinfections of HHV-6A in two of the three. They characterized the first full genome sequence of ciHHV-6A and demonstrated the inherited ciHHV6 genome was similar but distinct from known exogenous (community acquired) strains of HHV-6A .

CiHHV-6A is the dominant virus in malignancy and inflammatory disease cases, while ciHHV-6B is the dominant virus in myocarditis cases

In All, ciHHV-6, Heart Disease, News by hhv6foundation

A sequencing study led by Ursula Gompels of London School of Hygiene & Tropical Medicine, found that 95% (19/21) of Czech ciHHV-6 malignancy and inflammatory disease patients had ciHHV6A while 65% (13/20) of a German myocarditis cohort had ciHHV-6B. The authors propose that this divergence suggests different disease links for the two viruses.