Could HHV-6B infection exacerbate mitochondrial disease?
Could herpesvirus infection of endothelial cells be important in the pathophysiology of ME/CFS?
A recent review summarizes evidence that HHV-6 can cause endothelial dysfunction, which often is seen in both Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.
Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID
Autoantibodies directed against neural targets have most predictive power.
Antibodies to HHV-6 and HHV-6 dUTPase are strong predictors of Long COVID
CRP and IgA antibodies to activin-A are also important predictors.
HHV-6 found in postmortem study of myalgic encephalomyelitis/chronic fatigue syndrome
Because of small number of ME/CFS subjects, the study is provocative rather than conclusive.
Increased HHV-6B viral load and levels of autonomic autoantibodies in ME/CFS
Biomarkers distinguish cases from healthy controls, but don’t all correlate with disease severity.
The dUTPases of HHV-6A and EBV may encourage autoimmunity in ME/CFS
Viral dUTPases are strong inducers of activin A and enhance T follicular helper-cell differentiation.
Elevated HHV-6 and EBV dUTPase antibody levels found in older populations
It remains unclear if there are lower levels of these antibodies in younger age groups.
Reactivation of latent herpesviruses and HERVS after mild COVID-19
Findings are accentuated in people with myalgic encephalomyelitis/chronic fatigue syndrome.
HHV-6 as a trigger for chronic fatigue syndrome: a meta-analysis
Systematic review and meta-analysis confirm an association, but not a causal link, between HHV-6 and CFS
A review of evidence linking HHV-6A/B to neurological diseases: association or causation?
A thorough review examines the possible role of HHV-6A/B in febrile seizures, mesial temporal lobe epilepsy, multiple sclerosis and Alzheimer’s disease, proposing evidence to distinguish association from causation.
Levels of HHV-6B and HHV-7 DNA in saliva may distinguish people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome from healthy control subjects
Levels of HHV-6B and HHV-7 DNA in saliva were higher in people with ME/CFS than in health controls and tended to be higher at times symptoms were worse. Similar correlations were not seen for other human herpesviruses.
Latent HHV-6, mitochondrial fragmentation and a hypometabolic state in ME/CFS patients
A team of virologists and metabolomics specialists collaborated to demonstrate how chromosomally integrated HHV-6 can be stimulated to secrete factors that simultaneously cause mitochondrial fragmentation, a reduction in intracellular ATP reserve and an expanded antiviral defense by their neighboring cells.
Herpesvirus saliva DNA increases dramatically during spaceflight
A number of astronauts have complained about herpesvirus reactivations during flight, and several developed shingles. Investigators at NASA determined that space flight increases herpesvirus shedding in saliva, compared to levels before and after their missions.
Foscarnet approved for HHV-6 encephalitis in Japan
Although foscarnet is widely used for HHV-6 encephalitis, it has never been specifically approved for HHV-6. Japan’s Ministry of Health, Labor and Welfare was the first to approve foscarnet (Foscavir) for the treatment of HHV-6 encephalitis.
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