Because of small number of ME/CFS subjects, the study is provocative rather than conclusive.
Biomarkers distinguish cases from healthy controls, but don’t all correlate with disease severity.
Viral dUTPases are strong inducers of activin A and enhance T follicular helper-cell differentiation.
It remains unclear if there are lower levels of these antibodies in younger age groups.
Findings are accentuated in people with myalgic encephalomyelitis/chronic fatigue syndrome.
Systematic review and meta-analysis confirm an association, but not a causal link, between HHV-6 and CFS
A thorough review examines the possible role of HHV-6A/B in febrile seizures, mesial temporal lobe epilepsy, multiple sclerosis and Alzheimer’s disease, proposing evidence to distinguish association from causation.
Levels of HHV-6B and HHV-7 DNA in saliva were higher in people with ME/CFS than in health controls and tended to be higher at times symptoms were worse. Similar correlations were not seen for other human herpesviruses.
A team of virologists and metabolomics specialists collaborated to demonstrate how chromosomally integrated HHV-6 can be stimulated to secrete factors that simultaneously cause mitochondrial fragmentation, a reduction in intracellular ATP reserve and an expanded antiviral defense by their neighboring cells.
A number of astronauts have complained about herpesvirus reactivations during flight, and several developed shingles. Investigators at NASA determined that space flight increases herpesvirus shedding in saliva, compared to levels before and after their missions.
Although foscarnet is widely used for HHV-6 encephalitis, it has never been specifically approved for HHV-6. Japan’s Ministry of Health, Labor and Welfare was the first to approve foscarnet (Foscavir) for the treatment of HHV-6 encephalitis.
HHV-6 was found to be significantly correlated with nerve fiber damage severity by Latvian investigators. 51% of fibromyalgia patients had detectable HHV-6 DNA in whole blood compared to just 6% of controls.
Investigators from Japan looked at HHV-6 and HHV-7 DNA levels in saliva to see if they might be biomarkers for cancer-related fatigue (CRF) in multiple myeloma patients.
Antibodies to HHV-6 and VZV dUTPases were significantly elevated in Gulf War Illness patients compared to controls, and EBV dUTPase antibodies were elevated in Chronic Fatigue Syndrome patients.
A prospective study authored by Joshua Hill and Danielle Zerr determined that higher than average HHV-6B DNA levels increased the odds of developing delirium after cord blood transplantation (CBT) by almost three fold. Patients with DNA loads in the top quartile had a 4.5 fold increase in delirium.
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