• Foscarnet prophylaxis improved engraftment and survival in cord blood transplant patients

    Six-month overall survival was 96% in the treated group compared to 72% in the untreated group.

  • Latent HHV-6B infection of astrocytes may increase the risk of depression by activating the HPA axis

    Japanese investigators show that a protein expressed by latent HHV-6B in astrocytes, results in an influx of extra-cellular calcium, triggering the onset of depression.

  • Mothers with iciHHV6 have an increased risk of spontaneous abortion

    27.6% of Japanese mothers with iciHHV6 had a spontaneous abortion compared to 14.8% of controls. iciHHV6 mothers were also 6.4X more likely to have two or more spontaneous abortions.

  • Significantly worse outcomes in critically ill hematology patients associated with HHV-6 infection.

    Two reports associate detectable HHV-6 DNA in body fluids with increased risk of mortality in patients being treated for hematologic malignancies.

Newsletter | About Us | Contact Us | Donate | Repository

HHV-6 Foundation | HHV-6 Disease Information for Patients, Clinicians, and Researchers | Apply for a Grant Navigation
  • Home
  • About
    • Scientific Office
    • Scientific Advisory Board
    • Executive Director & Staff
    • Board of Directors
    • Contact Us
    • Donate
  • Patients
    • What Is HHV-6?
    • HHV-6A/B Testing
    • HHV-6 Treatment
    • Patient FAQ
    • Conditions Associated with HHV-6
    • HHV-6 & Immune Suppression
    • Immune Stimulants
    • Chromosomally Integrated HHV-6 (ciHHV-6)
    • CIHHV-6 Testing
  • Research
    • Latest HHV-6 Research
    • Grants
    • Repository
      • Cart
      • Checkout
    • HHV-6A/B Testing
    • List of Genes & Proteins
    • Lab Protocols
    • Pictorial Atlas of HHV-6
    • HHV-6 Antivirals
    • Researcher FAQ
    • Newsletter
  • Clinicians
    • HHV-6A/B Testing
    • HHV-6 Treatment
      • HHV-6 Antivirals
      • Immune Stimulants
    • Alternative Treatments
      • Antiviral use in transplant patients with HHV-6 encephalitis
      • More about foscarnet, ganciclovir and cidovofir
    • HHV-6 & Immune Suppression
    • Chromosomally Integrated HHV-6 (ciHHV-6)
    • CIHHV-6 Testing
    • 10 Surprising Facts about CIHHV-6
  • Conditions
    • Associated Conditions A-H
      • Amnesia
      • Cancer
      • Chromosomally Integrated HHV-6 (ciHHV-6)
      • Chronic Fatigue Syndrome
      • Cognitive Dysfunction
      • Colitis/Diarrhea
      • Drug Hypersensitivity
      • Encephalitis
      • Endocrine Disorders
      • Endothelial Cell Dysfunction
      • Epilepsy
      • Heart Disease
      • HIV/AIDS Progression
    • Associated Conditions I-Z
      • Immune Suppression
      • Kidney Disease
      • Liver Disease
      • Lung Disease
      • Mononucleosis/Lymphadenopathy
      • Multiple Sclerosis
      • Neurological Conditions
      • Organ-Specific Diseases
      • Rash/Roseola
      • Transplant Complications
  • Home
  • About
    • Scientific Office
    • Scientific Advisory Board
    • Executive Director & Staff
    • Board of Directors
    • Contact Us
    • Donate
  • Patients
    • What Is HHV-6?
    • HHV-6A/B Testing
    • HHV-6 Treatment
    • Patient FAQ
    • Conditions Associated with HHV-6
    • HHV-6 & Immune Suppression
    • Immune Stimulants
    • Chromosomally Integrated HHV-6 (ciHHV-6)
    • CIHHV-6 Testing
  • Research
    • Latest HHV-6 Research
    • Grants
    • Repository
      • Cart
      • Checkout
    • HHV-6A/B Testing
    • List of Genes & Proteins
    • Lab Protocols
    • Pictorial Atlas of HHV-6
    • HHV-6 Antivirals
    • Researcher FAQ
    • Newsletter
  • Clinicians
    • HHV-6A/B Testing
    • HHV-6 Treatment
      • HHV-6 Antivirals
      • Immune Stimulants
    • Alternative Treatments
      • Antiviral use in transplant patients with HHV-6 encephalitis
      • More about foscarnet, ganciclovir and cidovofir
    • HHV-6 & Immune Suppression
    • Chromosomally Integrated HHV-6 (ciHHV-6)
    • CIHHV-6 Testing
    • 10 Surprising Facts about CIHHV-6
  • Conditions
    • Associated Conditions A-H
      • Amnesia
      • Cancer
      • Chromosomally Integrated HHV-6 (ciHHV-6)
      • Chronic Fatigue Syndrome
      • Cognitive Dysfunction
      • Colitis/Diarrhea
      • Drug Hypersensitivity
      • Encephalitis
      • Endocrine Disorders
      • Endothelial Cell Dysfunction
      • Epilepsy
      • Heart Disease
      • HIV/AIDS Progression
    • Associated Conditions I-Z
      • Immune Suppression
      • Kidney Disease
      • Liver Disease
      • Lung Disease
      • Mononucleosis/Lymphadenopathy
      • Multiple Sclerosis
      • Neurological Conditions
      • Organ-Specific Diseases
      • Rash/Roseola
      • Transplant Complications

Latest Alzheimer’s Disease Articles

View Post

Murine roseolovirus (MRV) infection experiments are only partially supportive of role of HHV-6A/B in Alzheimer’s disease

While MRV administered peripherally led to brain infection and neuroinflammation, it did not increase Aß deposition

View Post

HHV-6A promotes inflammation in astrocytoma cells by dysregulating autophagy

Infection increases ROS, induces ER stress and activates STAT3, NF-κB and mTOR pathways.

View Post

A potential mechanism by which HHV-6A infection could promote Alzheimer’s Disease

HHV-6A was found to both enhance expression and inhibit degradation of amyloid precursor protein in vitro.

View Post

The role of HHV-6 in dysregulating autophagy

HHV-6, like some other herpesviruses, dysregulates autophagy in multiple cell types, with important biological consequences.

View Post

HHV-6A/B in brain disease: proposed criteria for establishing causation

Three top experts on HHV-6A/B teamed up to write a comprehensive review and propose criteria for establishing HHV-6A/B to MS, epilepsy and Alzheimer’s disease.

View Post

HHV-6A and the suppression of miR155 in Alzheimer’s pathology

Dysregulation of the microRNA miR155 is associated with pathophysiological progression of Alzheimer’s disease. HHV-6A has been shown to suppress miR155.

View Post

Clonally expanded CD8 T cells in spinal fluid of Alzheimer’s patients suggest an adaptive immune response to pathogens

Researchers at the NIH used RNA-Seq cells from skin and blood to study the underlying mechanisms in DIHS/DRESS and identified both HHV-6 and JAK-STAT pathways as potential targets. Central memory CD4+T cells were enriched with HHV-6B.

View Post

NINDS/NIH investigators find very little HHV-6 RNA or DNA in either Alzheimer’s or control brains

A team led by Steven Jacobson, PhD at NINDS analyzed RNA-seq datasets from 901 brains, and found only 1.2% of Alzheimer’s patients and 0.4% of controls positive for HHV-6 RNA. They also found HHV-6 DNA in less than 4% of samples tested by ddPCR.

View Post

The debate continues over RNA-seq analysis of HHV-6A in Alzheimer’s

Two groups have challenged the widely-publicized 2018 study in 2018, that found increased HHV-6A & 7 abundance and an association with clinical and pathology scores in Alzheimer’s. The topic has become the focus vigorous debate.

View Post

HHV-6A induces dysregulation of autophagy in neurons and astrocytoma cells, increasing beta-amyloid and tau

Building on their prior work, an Italian team has shown that HHV-6A is able to induce dysregulation of autophagy in neurons and astrocytoma cells, increasing amyloid beta and tau production.

View Post

HHV-6A activates microglia and increases Aβ and tau expression

HHV-6A infection of microglia cells increases inflammatory markers and Aβ and tau expression dramatically, supporting the hypothesis that plaque development in Alzheimer’s disease may be an innate immune response to pathogens

View Post

HHV-6B induces ER stress in primary monocytes, impairing their survival and differentiation into dendritic cells

Investigators propose that the induction of endoplasmic reticulum stress, likely exacerbated by autophagy inhibition, could contribute to the immune suppression induced by HHV-6B in exanthem subitem patients.

View Post

Differential gene expression pattern shared in herpesviruses, Alzheimer’s & Parkinson’s patients

Researchers from GlaxoSmithKline found a significant overlap in differentially expressed genes shared by those with herpesvirus infections, Alzheimer’s and Parkinson’s. On the other hand, there was no significant overlap between herpesviruses and Type 2 diabetes or Huntington’s disease.

View Post

Herpesvirus acquires protein corona that facilitates the formation of Alzheimer’s plaques

Swedish researchers report that viruses interact with proteins to form a coating or protein corona that facilitates the formation of amyloid plaque, supporting previous findings by Harvard’s Rudy Tanzi and Robert Moir.

View Post

Single-cell transcriptomic analysis of Alzheimer’s brains showed early changes that are highly cell-type specific with APOE strongly upregulated in the microglia

MIT examined transcription across tens of thousands of individual cells in both Alzheimer’s and healthy brains and found APOE strongly upregulated in the microglia and perturbation in myelination-related processes in multiple cell types including oligodendrocytes.

  • Page 1 of 2
  • 1
  • 2
  • →

Clinical News

  • Alzheimer’s Disease
  • Animal Models
  • Autoimmune Disease
  • Cancer
  • iciHHV-6
  • CNS Disease
  • COVID-19 / HHV-6 Reactivation
  • Drug Hypersensitivity
  • Encephalitis & Encephalopathy
  • Endocrine Conditions
  • Epilepsy and Seizures
  • Gastrointestinal
  • Genes
  • Heart Disease
  • Hematological Disorders
  • HIV/AIDS Progression
  • Immunity & Immunotherapy
  • Infertility & Miscarriage
  • Kidney Disease
  • Liver Disease
  • Lung Disease
  • Lymphadenopathy & Fever
  • ME/CFS
  • Multiple Sclerosis
  • Rash & Roseola
  • Transplant Complications
  • Treatments – Adoptive T cell
  • Treatments – Alternative
  • Treatments – Antiviral
  • Treatments – Immune Stimulant

Scientific News

  • Latest Scientific News

About HHV-6

  • What Is HHV-6?
  • What is Inherited Chromosomally Integrated HHV-6
  • HHV-6 Repository of Reagents
  • HHV-6A/B Testing
  • HHV-6 Treatment

SUBSCRIBE TO OUR NEWSLETTER

ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

Read More

HHV-6 Foundation | 1482 East Valley Road, Suite 619 | Santa Barbara, CA, 93108 | Toll Free: (888) 530-6726


Copyright ©2004-2022 HHV-6 FOUNDATION


WEB DESIGN AND DEVELOPMENT BY INSTYLE TECHNOLOGIES
  • Home
  • About
  • Conditions
  • Clinicians
  • Testing
  • Research
  • Repository
  • Patients
  • Treatment
  • News & Blog
  • Donate
  • Contact Us
  • Cart
  • Checkout
  • Privacy Policy
  • Terms of Use