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CXCL11 and CCL2 are specific to HHV-6B in febrile infants

In All, Alzheimer's Disease, Multiple Sclerosis by Kristin Loomis

Japanese investigators from Kobe University identified CXC11 as a chemokine uniquely expressed in primary HHV-6B infections. They also confirmed a previous finding that cytokine CCL2 (MCP-1) plays a role in HHV-6B primary infections. Both CXCL11 and CCL2 are expressed in several neuroinflammatory conditions including epilepsy, Alzheimer’s disease and traumatic brain injury.

Elevated levels of HHV-6 DNA in Alzheimer’s, linked to variants in antiviral genes

In All, Alzheimer's Disease by hhv6foundation

A group from Italy’s University of Bologna report that genetic defects in antimicrobial defense mechanisms can leave some individuals vulnerable to sub-clinical infections that lead to cognitive decline as they age. They found variations in specific antiviral genes that correlate with HHV-6 DNA levels in brain tissue and blood from patients with Alzheimer’s disease.