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HHV-6A, infertility and miscarriage: a hypothesis

In All, Endocrine Conditions, Immunology, Infertility & Miscarriage by Kristin Loomis

Growing evidence implicates HHV-6, especially HHV-6A, in some cases of female infertility, miscarriage, and other gestational problems affecting both the mother and child. The authors of the paper wonder if heparin, an anticoagulant with antiviral properties often used to treat infertility, might mitigate the detrimental effects of HHV-6 in the uterine environment.

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HHV-6A infection of the uterus linked to infertility

In All, Endocrine Conditions, Host Cell Interaction, Infertility & Miscarriage by Kristin Loomis

A new study reported that HHV-6A infects the lining of the uterus in 43% of women with unexplained infertility but cannot be found in uterine lining of fertile women.  Furthermore, the cytokine and the natural killer cell profiles were very different in patients with the infection. HHV-6A was found only in uterine endothelial cells, and not in the blood.

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Specific NK Cell subsets Associated with HHV-6 Infection in Hashimoto’s Thyroiditis

In All, Endocrine Conditions, Thyroid Disease by Kristin Loomis

Human herpesvirus-6 (HHV-6) has been associated with several autoimmune diseases. A recent study led by Rizzo and Caselli have found a possible link to Hashimoto’s Thyroiditis (HT). They report that HHV-6 infection correlated with higher levels of a particular type of NK cell associated with a potent release of cytokines.

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New research shows HLA modulation caused by acute HHV-6A infection of mesothelial cells

In All, Endocrine Conditions, Latest Scientific News, Multiple Sclerosis, Thyroid Disease by Kristin Loomis

HHV-6A infection of mesothelial cells causes HLA molecule modulation. This study demonstrates, for the first time, that human mesothelial cells are susceptible to HHV-6A infection. They also show that the virus causes modulated HLA expression on the cell surface, inducing the de novo expression of HLA class II and HLA-G