• 12th International Conference on HHV-6 & 7 Announced

    The 12th International Conference on HHV-6 & 7 will convene in Japan at the Himeji Culture and Convention Center in March 2025.

  • Short-course foscarnet at an early stage may suppress HHV-6 reactivation following allogenic HCT

    Observational study suggests that an early one-week treatment at the first sign of viral reactivation may achieve clinical benefits and avoid antiviral toxicity.

  • Herpesvirus Reactivation Common in Severe COVID-19

    HHV-6 was the most common herpesvirus found when tested in nasal swabs, but EBV was the most common in plasma.

  • High levels of HHV-6A DNA found in blood of 52% of kidney transplant patients

    HHV-6A was the most common virus identified, but was not linked to worse outcomes compared to other viral infections.

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Latest Autoimmune Disease Articles

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EBV DNA found in 42% of lupus patients compared to 3% of controls; 25% had EBV IgM antibodies compared to <1% of controls

HHV-6 DNA is not elevated in lupus patients but may have a role in reactivating EBV.

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Are herpesviruses reactivated more often in acute COVID-19?

Systematic review and meta-analysis found strong evidence for EBV in the seriously ill; only 6 of 36 studies included HHV-6 testing.

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Coinfection of CMV and HHV-6A boosts fibrosis-associated microRNAs in fibroblasts

Investigators see possible links to systemic sclerosis, liver fibrosis and cardiovascular remodeling.

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Increased HHV-6B viral load and levels of autonomic autoantibodies in ME/CFS

Biomarkers distinguish cases from healthy controls, but don’t all correlate with disease severity.

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Two HHV-6 genes may contribute to pathogenesis of autoimmune thyroiditis

Genes U12 and U51 encode homologues of human G-protein-coupled receptors, and are potential triggers of autoimmunity.

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HHV-6, enterovirus and parvovirus B-19 found in the thyroid tissue of both autoimmune disease patients… and controls

Failure to distinguish HHV-6A from HHV-6A/B, and questions about assay sensitivity, make results difficult to interpret.

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HHV-6A and HCMV induce pro-fibrotic miRNA expression pattern in infected host cells

Pattern consistent with clinical studies suggesting these viruses may be one trigger of systemic sclerosis.

View Post

Neonatal murine roseolovirus infection induces autoimmunity

Early infection interferes with normal thymocyte development and disrupts central tolerance resulting in autoimmune disease later in life. Only infection during this critical time period resulted in autoimmunity.

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A comprehensive review of the role and potential functions HHV-6A/B U94

The review covers the role the U94 gene product plays in the virus’s life cycle, replication, and latency, as well as in the immune response.

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The role of HHV-6 in dysregulating autophagy

HHV-6, like some other herpesviruses, dysregulates autophagy in multiple cell types, with important biological consequences.

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iciHHV-6 not found to increase the risk of chronic autoimmune disease

Japanese investigators found no cases of iciHHV6 among 846 patients with several chronic autoimmune diseases

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No HHV-6 DNA found in the spinal fluid of immunocompetent adults evaluated for limbic encephalitis

While HHV-6B is well known to cause limbic encephalitis in transplant patients, it does not appear to play a role in other forms of limbic encephalitis.

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HHV-6A detected in the skin biopsies of systemic sclerosis patients

A group led by Elisabetta Caselli at University of Ferrara discovered HHV-6A in the skin and elevated levels of HHV6-B in the peripheral blood of systemic sclerosis patients

View Post

HHV-6B is found at higher levels in the pancreatic islets of type 1 diabetes patients

Investigators from the La Jolla Institute of Immunology used high-resolution confocal microscopy to detect high levels of HHV-6 protein in the pancreatic islet cells from donors with type 1 diabetes.

View Post

HHV-6 and EBV found in the brain tissue of Rasmussen’s Encephalitis patients

Chinese investigators found a high prevalence of HHV-6 and Epstein Barr virus in the brain tissues of children with Rasmussen’s encephalitis but in none of the controls. There was a significant association between viral presence and brain atrophy, raising a strong suspicion for the involvement of both viruses.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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