• Foscarnet prophylaxis improved engraftment and survival in cord blood transplant patients

    Six-month overall survival was 96% in the treated group compared to 72% in the untreated group.

  • Latent HHV-6B infection of astrocytes may increase the risk of depression by activating the HPA axis

    Japanese investigators show that a protein expressed by latent HHV-6B in astrocytes, results in an influx of extra-cellular calcium, triggering the onset of depression.

  • Mothers with iciHHV6 have an increased risk of spontaneous abortion

    27.6% of Japanese mothers with iciHHV6 had a spontaneous abortion compared to 14.8% of controls. iciHHV6 mothers were also 6.4X more likely to have two or more spontaneous abortions.

  • Significantly worse outcomes in critically ill hematology patients associated with HHV-6 infection.

    Two reports associate detectable HHV-6 DNA in body fluids with increased risk of mortality in patients being treated for hematologic malignancies.

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Latest Autoimmune Disease Articles

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Coinfection of CMV and HHV-6A boosts fibrosis-associated microRNAs in fibroblasts

Investigators see possible links to systemic sclerosis, liver fibrosis and cardiovascular remodeling.

View Post

Increased HHV-6B viral load and levels of autonomic autoantibodies in ME/CFS

Biomarkers distinguish cases from healthy controls, but don’t all correlate with disease severity.

View Post

Two HHV-6 genes may contribute to pathogenesis of autoimmune thyroiditis

Genes U12 and U51 encode homologues of human G-protein-coupled receptors, and are potential triggers of autoimmunity.

View Post

HHV-6, enterovirus and parvovirus B-19 found in the thyroid tissue of both autoimmune disease patients… and controls

Failure to distinguish HHV-6A from HHV-6A/B, and questions about assay sensitivity, make results difficult to interpret.

View Post

HHV-6A and HCMV induce pro-fibrotic miRNA expression pattern in infected host cells

Pattern consistent with clinical studies suggesting these viruses may be one trigger of systemic sclerosis.

View Post

Neonatal murine roseolovirus infection induces autoimmunity

Early infection interferes with normal thymocyte development and disrupts central tolerance resulting in autoimmune disease later in life. Only infection during this critical time period resulted in autoimmunity.

View Post

A comprehensive review of the role and potential functions HHV-6A/B U94

The review covers the role the U94 gene product plays in the virus’s life cycle, replication, and latency, as well as in the immune response.

View Post

The role of HHV-6 in dysregulating autophagy

HHV-6, like some other herpesviruses, dysregulates autophagy in multiple cell types, with important biological consequences.

View Post

iciHHV-6 not found to increase the risk of chronic autoimmune disease

Japanese investigators found no cases of iciHHV6 among 846 patients with several chronic autoimmune diseases

View Post

No HHV-6 DNA found in the spinal fluid of immunocompetent adults evaluated for limbic encephalitis

While HHV-6B is well known to cause limbic encephalitis in transplant patients, it does not appear to play a role in other forms of limbic encephalitis.

View Post

HHV-6A detected in the skin biopsies of systemic sclerosis patients

A group led by Elisabetta Caselli at University of Ferrara discovered HHV-6A in the skin and elevated levels of HHV6-B in the peripheral blood of systemic sclerosis patients

View Post

HHV-6B is found at higher levels in the pancreatic islets of type 1 diabetes patients

Investigators from the La Jolla Institute of Immunology used high-resolution confocal microscopy to detect high levels of HHV-6 protein in the pancreatic islet cells from donors with type 1 diabetes.

View Post

HHV-6 and EBV found in the brain tissue of Rasmussen’s Encephalitis patients

Chinese investigators found a high prevalence of HHV-6 and Epstein Barr virus in the brain tissues of children with Rasmussen’s encephalitis but in none of the controls. There was a significant association between viral presence and brain atrophy, raising a strong suspicion for the involvement of both viruses.

View Post

HHV-6B found in the islet cells of both type 1 diabetes patients and controls

Swedish investigators have found HHV-6 protein in the pancreatic islet cells of both type 1 diabetes patients and controls. The viral load was higher in the islet cells than in surrounding tissues. Unfortunately, they did not provide data on the difference between patients and controls in the viral load.

View Post

Antibodies to herpesvirus dUTPase a potential biomarker for Gulf War Illness and CFS

Antibodies to HHV-6 and VZV dUTPases were significantly elevated in Gulf War Illness patients compared to controls, and EBV dUTPase antibodies were elevated in Chronic Fatigue Syndrome patients.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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