Review summarizes experience from Japan and U.S.
More evidence supporting the role of HHV-6 and HHV-7 as possible triggers of pityriasis rosea
Argument rests on the use of a putatively more sensitive diagnostic technique.
iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations
iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.
Single-cell RNA sequencing was used to determine the tropism of MRV in the thymus and how central tolerance is disrupted
A new cell culture model for MRV could offer insights on the development of autoimmunity after neonatal infection.
Co-infection of HHV-6A and EBV results in a 6.7 fold increased risk of developing multiple sclerosis
The increased risk occurred only in adults who were infected with EBV after their teenage years, and had elevated EBNA-1 antibodies.
MicroRNA expression patterns suggest that HHV-6 may play a role in triggering systemic sclerosis
Expression pattern of several miRNAs in SS tissue parallels the pattern generated when dermal fibroblasts and endothelial cells are infected by HHV-6A and CMV.
Could HHV-6 reactivation in drug hypersensitivity trigger fulminant type 1 diabetes?
Small study demonstrates increased HHV-6 antibodies in all patients shortly before the onset of DIHS-associated fulminant diabetes.
EBV DNA found in 42% of lupus patients compared to 3% of controls; 25% had EBV IgM antibodies compared to <1% of controls
HHV-6 DNA is not elevated in lupus patients but may have a role in reactivating EBV.
Are herpesviruses reactivated more often in acute COVID-19?
Systematic review and meta-analysis found strong evidence for EBV in the seriously ill; only 6 of 36 studies included HHV-6 testing.
Coinfection of CMV and HHV-6A boosts fibrosis-associated microRNAs in fibroblasts
Investigators see possible links to systemic sclerosis, liver fibrosis and cardiovascular remodeling.
Increased HHV-6B viral load and levels of autonomic autoantibodies in ME/CFS
Biomarkers distinguish cases from healthy controls, but don’t all correlate with disease severity.
Two HHV-6 genes may contribute to pathogenesis of autoimmune thyroiditis
Genes U12 and U51 encode homologues of human G-protein-coupled receptors, and are potential triggers of autoimmunity.
HHV-6, enterovirus and parvovirus B-19 found in the thyroid tissue of both autoimmune disease patients… and controls
Failure to distinguish HHV-6A from HHV-6A/B, and questions about assay sensitivity, make results difficult to interpret.
HHV-6A and HCMV induce pro-fibrotic miRNA expression pattern in infected host cells
Pattern consistent with clinical studies suggesting these viruses may be one trigger of systemic sclerosis.
Neonatal murine roseolovirus infection induces autoimmunity
Early infection interferes with normal thymocyte development and disrupts central tolerance resulting in autoimmune disease later in life. Only infection during this critical time period resulted in autoimmunity.