HHV-6 DNA is not elevated in lupus patients but may have a role in reactivating EBV.
Systematic review and meta-analysis found strong evidence for EBV in the seriously ill; only 6 of 36 studies included HHV-6 testing.
Investigators see possible links to systemic sclerosis, liver fibrosis and cardiovascular remodeling.
Biomarkers distinguish cases from healthy controls, but don’t all correlate with disease severity.
Genes U12 and U51 encode homologues of human G-protein-coupled receptors, and are potential triggers of autoimmunity.
Failure to distinguish HHV-6A from HHV-6A/B, and questions about assay sensitivity, make results difficult to interpret.
Pattern consistent with clinical studies suggesting these viruses may be one trigger of systemic sclerosis.
Early infection interferes with normal thymocyte development and disrupts central tolerance resulting in autoimmune disease later in life. Only infection during this critical time period resulted in autoimmunity.
The review covers the role the U94 gene product plays in the virus’s life cycle, replication, and latency, as well as in the immune response.
HHV-6, like some other herpesviruses, dysregulates autophagy in multiple cell types, with important biological consequences.
Japanese investigators found no cases of iciHHV6 among 846 patients with several chronic autoimmune diseases
While HHV-6B is well known to cause limbic encephalitis in transplant patients, it does not appear to play a role in other forms of limbic encephalitis.
A group led by Elisabetta Caselli at University of Ferrara discovered HHV-6A in the skin and elevated levels of HHV6-B in the peripheral blood of systemic sclerosis patients
Investigators from the La Jolla Institute of Immunology used high-resolution confocal microscopy to detect high levels of HHV-6 protein in the pancreatic islet cells from donors with type 1 diabetes.
Chinese investigators found a high prevalence of HHV-6 and Epstein Barr virus in the brain tissues of children with Rasmussen’s encephalitis but in none of the controls. There was a significant association between viral presence and brain atrophy, raising a strong suspicion for the involvement of both viruses.
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