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Inherited ciHHV-6 increases risk of developing acute GVHD and CMV in transplant patients.

In All, Cancer, ciHHV-6, GVHD by Kristin Loomis

A higher prevalence of inherited virus was found in patients

Investigators at Fred Hutchinson Cancer Center determined that transplant patients with inherited ciHHV-6 were twice as likely to develop acute graft vs host disease and three times more likely to develop high level CMV viremia. Transplant patients were also significantly more likely to have inherited ciHHV-6 than donors.

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HHV-6 reactivation, monocytes and B cells are unusually elevated in cord blood transplant patients

In All, Transplant Complications by Kristin Loomis

CD8+ T cells recover but CD4+ T cells remain low

Investigators in France discovered that monocytes and B lymphocytes recover quickly and become abnormally elevated by day 75 in cord blood patients, while they remain below normal or normal in stem cell patients. Although CD8 T cells recover, CD4+ T cells remain below normal levels for six months in both groups.

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HHV-6A, infertility and miscarriage: a hypothesis

In All, Endocrine Conditions, Immunology, Infertility & Miscarriage by Kristin Loomis

Growing evidence implicates HHV-6, especially HHV-6A, in some cases of female infertility, miscarriage, and other gestational problems affecting both the mother and child. The authors of the paper wonder if heparin, an anticoagulant with antiviral properties often used to treat infertility, might mitigate the detrimental effects of HHV-6 in the uterine environment.

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New mouse model for HHV-6 & 7

In All, Animal Models by Kristin Loomis

Investigators at Washington University have sequenced a murine herpesvirus and determined that it is closely related to HHV-6 & 7. Named Murine Rosesolovirus (MRV), the virus causes severe depletion of CD4+ T cells and thymic necrosis in young mice. The authors believe that MRV will be a useful mouse model to study the impact of HHV-6 & 7 in humans.

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Multiple viral infections and HHV-6B increase risk of mortality in HSCT

In All, Transplant Complications by Kristin Loomis

A retrospective study of allogeneic hematopoietic stem cell transplant patients at University of Washington found that reactivation of several double stranded DNA viruses significantly increased the risk of overall mortality, as did an increased quantitative burden of viral exposure. HHV-6B conferred a significantly increased risk for overall mortality.