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New mouse model for HHV-6 & 7

In All, Animal Models by Kristin Loomis

Investigators at Washington University have sequenced a murine herpesvirus and determined that it is closely related to HHV-6 & 7. Named Murine Rosesolovirus (MRV), the virus causes severe depletion of CD4+ T cells and thymic necrosis in young mice. The authors believe that MRV will be a useful mouse model to study the impact of HHV-6 & 7 in humans.

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Multiple viral infections and HHV-6B increase risk of mortality in HSCT

In All, Transplant Complications by Kristin Loomis

A retrospective study of allogeneic hematopoietic stem cell transplant patients at University of Washington found that reactivation of several double stranded DNA viruses significantly increased the risk of overall mortality, as did an increased quantitative burden of viral exposure. HHV-6B conferred a significantly increased risk for overall mortality.

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HHV-6 induced amnesia after rituximab therapy for autoimmune disease

In All, CNS Dysfunction, Encephalitis & Encephalopathy, Transplant Complications by Kristin Loomis

A young woman on rituximab and two other immunomodulatory agents for the treatment of dermatomyositis developed encephalitis with severe anterograde amnesia. As the use of biologic treatments for refractory autoimmune disease has been increasing, physicians are advised to consider HHV-6 and offer prompt antiviral therapy to limit irreversible morbidity.

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Does the high level of U94 in iciHHV-6 contribute to abnormal ‘marker’ chromosomes and cancer?

In All, Cancer, ciHHV-6 by Kristin Loomis

Investigators from the University of Ferrara, Italy have found evidence suggesting that high levels of U94 in ciHHV6 may predispose to the formation of marker chromosomes. A patient with diffuse large B-cell lymphoma positive for inherited chromosomally integrated HHV-6A and HHV-6A was also found in a marker chromosome, an abnormal piece of chromosome that is seen in some leukemia and lymphomas.

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Announcing the new “Dharam Ablashi Research Fund”

In All by Kristin Loomis

The HHV-6 Foundation is pleased to announce the creation of a new $250,000 research fund to honor the work Dharam Ablashi, the co-discoverer of HHV-6. The gift was made possible by a generous donation from a patient family in appreciation of Dharam’s outstanding service to the field of HHV-6 research over four decades. The funds will be used to offer pilot grants of up to $25,000 each to investigators seeking to gather preliminary data before embarking on larger studies.

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HHV-6 identified in 12% of simple and 42% of complex pediatric febrile seizures

In All, CNS Disease, CNS Dysfunction, Epilepsy and Seizures by Kristin Loomis

Australian investigators studied 143 young children with febrile seizures for signs of viral infection and found that HHV-6 was the fifth most common virus after rhinovirus (22%), enterovirus (20%), adenovirus (21%) and influenza (13%). Overall, a virus was found in 71% of cases. Virus found in complex seizures was associated with HHV-6 (42%) or influenza (41%).