Outcomes worse for the subtype linked to EBV and HHV-6.
iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations
iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.
HHV-6 reactivation in patients with DRESS associated with worse outcomes
Similar findings with EBV and CMV reactivation; causation vs. correlation unclear.
A retrospective study of haploidentical alloHCT patients found no outcome differences between treated patients with high viral loads (log10 4.65) and untreated patients with lower viral loads (log10 3.84)
Controlled studies are needed to determine the benefit of antiviral therapy in patients with high viral >10,000 copies/ mL.
While frequently detected in immunocompromised patients, HHV-6 is rarely found in the lungs of immunocompetent patients
Two groups of investigators in China used next-generation sequencing to identify EBV, HHV-7, HSV1 and CMV as the most common herpesviruses in immunocompetent pneumonia patients.
A variety of techniques greatly increase the efficiency of HHV-6A reconstitution and replication using BACs
Improving efficiency of reconstitution may aid in study of HHV-6 biology.
HHV-6 and HHV-7 frequently identified in the spinal fluid of patients with suspected encephalitis
Next-generation sequencing proves valuable for identifying CNS infections in the immunocompetent.
Could herpesvirus infection of endothelial cells be important in the pathophysiology of ME/CFS?
A recent review summarizes evidence that HHV-6 can cause endothelial dysfunction, which often is seen in both Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.
Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID
Autoantibodies directed against neural targets have most predictive power.
HHV-6-IgG antibodies correlate with evidence of leaky gut in patients with Long COVID
Whether HHV-6 has a causal role in leaky gut is not addressed.
Telomeric repeats (TMRs) important for Marek’s Disease virus live vaccine efficacy
Chromosomal integration and maintenance, as well as vaccine efficacy, severely impaired in the absence of TMRs.
What went wrong with posoleucel: a virus-specific cytotoxic T cell therapy?
Results from preclinical and Phase 2 studies were encouraging, but Phase III trials were cancelled.
HHV-6 reactivation may influence graft rejection in pediatric kidney and liver transplantation
Cytokines IL-4, IL-8 and IL-10 correlated with graft rejection and were elevated in HHV-6+ patients.
A remarkably low prevalence of iciHHV-6 (0- 0.24%) reported in two Finnish studies
Out of 1,276 pregnancies all three iciHHV-6 cases involved preeclampsia or growth restriction.
Clinical evidence that infections, including with herpesviruses, increase risk for neurodegeneration
Epidemiologic research supports the provocative hypothesis.