As with previous studies, HHV-6 reactivation delayed platelet engraftment and increased the risk of aGVHD.
Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA
Could HHV-6B infection exacerbate mitochondrial disease?
Review summarizes the substantial disease burden of primary HHV-6B infection in children
Review summarizes experience from Japan and U.S.
HHV-6 linked to miscarriage through Mendelian randomization studies
The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.
More evidence supporting the role of HHV-6 and HHV-7 as possible triggers of pityriasis rosea
Argument rests on the use of a putatively more sensitive diagnostic technique.
Hodgkin’s lymphoma has 3 subtypes, one linked to infection with EBV and HHV-6
Outcomes worse for the subtype linked to EBV and HHV-6.
iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations
iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.
HHV-6 reactivation in patients with DRESS associated with worse outcomes
Similar findings with EBV and CMV reactivation; causation vs. correlation unclear.
A retrospective study of haploidentical alloHCT patients found no outcome differences between treated patients with high viral loads (log10 4.65) and untreated patients with lower viral loads (log10 3.84)
Controlled studies are needed to determine the benefit of antiviral therapy in patients with high viral >10,000 copies/ mL.
While frequently detected in immunocompromised patients, HHV-6 is rarely found in the lungs of immunocompetent patients
Two groups of investigators in China used next-generation sequencing to identify EBV, HHV-7, HSV1 and CMV as the most common herpesviruses in immunocompetent pneumonia patients.
A variety of techniques greatly increase the efficiency of HHV-6A reconstitution and replication using BACs
Improving efficiency of reconstitution may aid in study of HHV-6 biology.
HHV-6 and HHV-7 frequently identified in the spinal fluid of patients with suspected encephalitis
Next-generation sequencing proves valuable for identifying CNS infections in the immunocompetent.
Could herpesvirus infection of endothelial cells be important in the pathophysiology of ME/CFS?
A recent review summarizes evidence that HHV-6 can cause endothelial dysfunction, which often is seen in both Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.
Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID
Autoantibodies directed against neural targets have most predictive power.
HHV-6-IgG antibodies correlate with evidence of leaky gut in patients with Long COVID
Whether HHV-6 has a causal role in leaky gut is not addressed.