• Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID

    Autoantibodies directed against neural targets have most predictive power.

  • iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

    iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

  • HHV-6 linked to miscarriage through Mendelian randomization studies

    The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.

  • Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

    Could HHV-6B infection exacerbate mitochondrial disease?

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Latest HHV-6 Research Articles

View Post

Herpesvirus “jumping genes” may contribute to Alzheimer’s disease

In All, Alzheimer's Disease, CNS Disease, Genes by Kristin LoomisApril 28, 2025

Transposable elements in aging brains were linked to herpesvirus RNA, predominantly HHV-6A, HHV-6B and HHV-7.

View Post

EBV and HHV-6 dUTPases explain 47% of the variance in autoantibody responses to myelin proteins in relapsing-remitting MS patients

In All, CNS Disease, Multiple Sclerosis by Kristin LoomisApril 28, 2025

Findings suggest that viral reactivation may trigger or sustain autoimmune responses in MS.

View Post

Leading HHV-6 investigators encourage using new name for iciHHV-6

In All, ciHHV-6, iciHHV-6 by Kristin LoomisApril 28, 2025

Read why some believe that “endogenous HHV-6” is a better term than inherited chromosomally integrated HHV-6, and sign on to their open letter if you agree.

View Post

Extracellular viral microRNAs as novel biomarkers to differentiate active from latent infections

In All, Genes, Transplant Complications by Kristin LoomisApril 28, 2025

Short non-coding RNA’s provide cell-free, activity-specific viral signatures.

View Post

High levels of herpesviruses found in patients suspected of bloodstream infections using metagenomic NGS sequencing of cfDNA

In All, Genes, Transplant Complications by Kristin LoomisApril 28, 2025

EBV was found in 28.6%; HHV-6 and CMV were found in 18.4% of cases.

View Post

HHV-6B Ribonucleotide Reductase Sequesters NF-κB Subunit p65 to Inhibit Innate Immune Responses

In All, Genes, Immunity & Immunotherapy by Kristin LoomisApril 28, 2025

This study helps explain how roseoloviruses maintain persistent infection.

View Post

Adding anti-thymocyte globulin to cyclophosphamide did not increase HHV-6 reactivation after haploidentical HCT

In All, Transplant Complications by Kristin LoomisMarch 2, 2025

As with previous studies, HHV-6 reactivation delayed platelet engraftment and increased the risk of aGVHD.

View Post

Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

In All, iciHHV-6, Kidney Disease, ME/CFS by Kristin LoomisMarch 2, 2025

Could HHV-6B infection exacerbate mitochondrial disease?

View Post

Review summarizes the substantial disease burden of primary HHV-6B infection in children

In All, Autoimmune Disease, Encephalitis & Encephalopathy, Epilepsy and Seizures, Rash & Roseola by Kristin LoomisMarch 2, 2025

Review summarizes experience from Japan and U.S.

View Post

HHV-6 linked to miscarriage through Mendelian randomization studies

In All, Infertility & Miscarriage by Kristin LoomisMarch 2, 2025

The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.

View Post

More evidence supporting the role of HHV-6 and HHV-7 as possible triggers of pityriasis rosea

In All, Autoimmune Disease, Rash & Roseola by Kristin LoomisMarch 2, 2025

Argument rests on the use of a putatively more sensitive diagnostic technique.

View Post

Hodgkin’s lymphoma has 3 subtypes, one linked to infection with EBV and HHV-6

In All, Cancer by Kristin LoomisFebruary 5, 2025

Outcomes worse for the subtype linked to EBV and HHV-6.

View Post

iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

In All, Autoimmune Disease, iciHHV-6 by Kristin LoomisFebruary 5, 2025

iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

View Post

HHV-6 reactivation in patients with DRESS associated with worse outcomes

In All, Drug Hypersensitivity by Kristin LoomisFebruary 5, 2025

Similar findings with EBV and CMV reactivation; causation vs. correlation unclear.

View Post

A retrospective study of haploidentical alloHCT patients found no outcome differences between treated patients with high viral loads (log10 4.65) and untreated patients with lower viral loads (log10 3.84)

In All, Transplant Complications, Treatments - Antiviral by Kristin LoomisFebruary 5, 2025

Controlled studies are needed to determine the benefit of antiviral therapy in patients with high viral >10,000 copies/ mL.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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