Investigators were surprised that the use of the less toxic CMV specific antiviral did not result in a significant increase in HHV-6-related disease.
Meta-Analysis links EBV, HHV-6 and VZV to multiple sclerosis
Study pools data from nearly 30,000 people with MS.
International expert panel publishes guidelines for management of DRESS
Guidelines recommend routinely assessing HHV-6 viral load, but not antiviral treatment when HHV-6 reactivation identified.
HHV-6 detectable in some urine samples, but not linked to disease
In contrast, human papillomavirus found more often in urine of bladder cancer patients than in urine of patients with non-cancerous urinary tract conditions.
Higher HHV-6 viral load in oral mucosa cells in people with major depression
Combination of viral load and presence of specific polymorphism in the TNF-α gene associated with major depression.
Phase III trials suspended for T-cell therapeutic active against HHV-6
In a surprise, multi-virus cytotoxic T cell therapy trials were terminated early for failure to meet endpoints.
Part 1: Latent HHV-6 is reactivated in patients receiving CAR-T cell therapy
Investigators urge careful monitoring for HHV-6 and ciHHV-6.
Part 2: CAR-T cell therapy and its complications
Could some complications of CAR-T cell therapy be secondary to HHV-6 infection?
Part 3. HHV-6 Encephalitis in CAR-T Cell therapy
Clearly documented cases of HHV-6 encephalitis have been reported, but some are missed because they were classified as ICAN or because HHV-6 testing was not performed in patients with mental status changes.
Part 4. Might HHV-6 contribute to some cases of cytokine release syndrome, pneumonia, and cytopenias in CAR-T Cell therapy?
While unlikely to trigger the cytokine storm, HHV-6 infection may perpetuate it, and contribute directly to cytopenias and pneumonia.
Early HHV-6 specific T-cell responses by ELISpot were remarkably higher in alloHSCT patients who went on to develop clinically relevant infections
T-cell responses correlate directly with clinical symptoms, and were better predictors of HHV-6 disease than viral load or total CD3+ counts.
Increased expression of HHV-6B receptor CD134/OX40 found in DIHS/DRESS skin lesions
The severity of DIHS/DRESS cases was significantly correlated with the frequency of CD134+ cells.
Thorough review of the role of HHV-6 in DIHS/DRESS
HHV-6 reactivation much more frequent than reactivation of other herpesviruses.
Review: HHV-6 is an important cause of persistent viral myocarditis, along with Parvovirus B-19 and adenovirus
SARS CoV-2 may lead to the activation of persistent herpesviruses in heart tissue.
Investigators find HHV-6 in the skin of DRESS patients two weeks before it is found in the blood in a large, multi-center case series
HHV-6 reactivation in both skin and blood was found frequently in severe cases.