Two groups of investigators in China used next-generation sequencing to identify EBV, HHV-7, HSV1 and CMV as the most common herpesviruses in immunocompetent pneumonia patients.
A variety of techniques greatly increase the efficiency of HHV-6A reconstitution and replication using BACs
Improving efficiency of reconstitution may aid in study of HHV-6 biology.
HHV-6 and HHV-7 frequently identified in the spinal fluid of patients with suspected encephalitis
Next-generation sequencing proves valuable for identifying CNS infections in the immunocompetent.
Could herpesvirus infection of endothelial cells be important in the pathophysiology of ME/CFS?
A recent review summarizes evidence that HHV-6 can cause endothelial dysfunction, which often is seen in both Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.
Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID
Autoantibodies directed against neural targets have most predictive power.
HHV-6-IgG antibodies correlate with evidence of leaky gut in patients with Long COVID
Whether HHV-6 has a causal role in leaky gut is not addressed.
Telomeric repeats (TMRs) important for Marek’s Disease virus live vaccine efficacy
Chromosomal integration and maintenance, as well as vaccine efficacy, severely impaired in the absence of TMRs.
What went wrong with posoleucel: a virus-specific cytotoxic T cell therapy?
Results from preclinical and Phase 2 studies were encouraging, but Phase III trials were cancelled.
HHV-6 reactivation may influence graft rejection in pediatric kidney and liver transplantation
Cytokines IL-4, IL-8 and IL-10 correlated with graft rejection and were elevated in HHV-6+ patients.
A remarkably low prevalence of iciHHV-6 (0- 0.24%) reported in two Finnish studies
Out of 1,276 pregnancies all three iciHHV-6 cases involved preeclampsia or growth restriction.
Clinical evidence that infections, including with herpesviruses, increase risk for neurodegeneration
Epidemiologic research supports the provocative hypothesis.
Neuroimaging and proteomic evidence that infections, including with herpesviruses, increase risk for neurodegeneration
Objective laboratory measurements also support the provocative hypothesis.
Epidemiologic study links varicella-zoster virus reactivation to dementia years later
Observational longitudinal study finds correlation.
Shingrix shingles vaccination shown to reduce the risk of dementia
A large UK study compared those who took a shingles vaccine to those who took only flu or Tdap vaccines.
Patients hospitalized with SARS-CoV-2 are twice as likely to develop Alzheimer’s or memory problems
Study does not address whether reactivated herpesviruses might be playing a role in the increased neurologic sequelae.