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Heart failure worsens in patients with persistent HHV-6B positive biopsies Numerous case reports and studies have now tied HHV-6 to myocarditis and cardiomyopathies. To further investigate this relationship, investigators from one of the top cardiology clinics in Europe performed a study to determine the outcome of patients discovered to have HHV-6 in their cardiac tissue during the initial biopsy screen.
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High HHV-6B viral loads found in a subset of epilepsy brain resections Investigators at the University of Bonn Medical Center in Germany have screened 346 fresh-frozen brain tissue resections from temporal lobe epilepsy (TLE) patients for all nine herpesviruses as well as for RNA viruses including Paramyxovirinae, Phleboviruses, Enteroviruses, and Flavivirus, using qPCR. HHV-6B was the only virus identified.
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HHV-6A reactivation in a ciHHV-6A transplant patient with encephalitis Experts emphasize need for larger studies to determine the impact of ciHHV-6 on patient outcomes
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Can a novel free radical scavenger help patients with HHV-6 encephalopathy? Edaravone shows promise for reducing oxidation and neuronal damage in AESD.
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Active ciHHV6 linked to heart failure, a condition treatable by antiviral therapy Berlin Charite study shows heart failure patients with active ciHHV-6 can be treated successfully with antivirals.
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Featured News

  • Call for Abstracts! November Conference on HHV-6 & 7 Call for Abstracts! November Conference on HHV-6 & 7
    The 9th International Conference on HHV-6 & 7 will be held November 9-11th at the Joseph B. Martin Conference Center at Harvard Medical School in Boston, USA.
  • Diagnosing infections in myocardial biopsies: Interview with Cardiologist Uwe Kühl and IKDT Lab Director Dirk Lassner Diagnosing infections in myocardial biopsies: Interview with Cardiologist Uwe Kühl and IKDT Lab Director Dirk Lassner
    The cardiology clinic at the Campus Benjamin Franklin, Charité – University Medicine Berlin is recognized as leading center for using state-of-the art mRNA analysis to diagnose active infections the biopsy tissue of myocarditis and heart failure patients.
  • Interview with Dr. Pitt Niehusmann: HHV-6 & MTLE Interview with Dr. Pitt Niehusmann: HHV-6 & MTLE
    Pitt Niehusmann has completed the largest study to date on the question of whether viruses play a role in refractory mesial temporal lobe epilepsy (MTLE), with an astonishing 346 samples analyzed. We asked Pitt a few questions about his work, which he will now continue at the University of Oslo, where he serves as a Senior Consultant Neuropathologist.
  • Special Issue on Roseoloviruses! Special Issue on Roseoloviruses!
    The December 2014 issue of Current Opinions in Virology features a "Special Section on Roseoloviruses." Top experts in the field contributed a set of 14 reviews that span a wide range of critical topics discussed at the recent June 2014 NIH-sponsored workshop “Roseoloviruses: Unmet needs and research priorities.”
  • Expert Opinion: Dr. Louis Flamand calls for screening of transplant organs and cells for ciHHV-6 status Expert Opinion: Dr. Louis Flamand calls for screening of transplant organs and cells for ciHHV-6 status
    Dr. Flamand, a professor and molecular virologist at Université Laval in Quebec city, has written an editorial calling for screening of organ donors for ciHHV-6 status and careful monitoring of recipients of ciHHV-6 donor tissues for signs of active HHV-6 infection and HHV-6 antigen-induced immune rejection. Flamand also questions whether solid organs and stem cells derived from persons with ciHHV-6 should be used in transplantation.
  • Interview with Michael Boeckh and Joshua Hill on potential risks for ciHHV6 patients undergoing HCT Interview with Michael Boeckh and Joshua Hill on potential risks for ciHHV6 patients undergoing HCT
    The University of Washington and the Fred Hutchinson Cancer Research Center are at the forefront of studying the role of HHV-6 and ciHHV-6 in stem cell transplant patients. We asked their view on the implications immunocompromised patients with integrated HHV-6A reactivating with their own inherited virus.
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Latest HHV-6 Research

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Repository of Reagents

Reagents for conducting HHV-6 & 7 research are available through the HHV-6 Foundation Repository

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About the Foundation

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B. The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since the HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge. Read More

ciHHV-6 Patient Registry

Except for transplant patients, HHV-6 plasma DNA tests are rarely positive. Any patient testing positive should rule out chromosomally integrated HHV-6, a condition that may be associated with increased HHV-6 reactivation.

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