• Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID

    Autoantibodies directed against neural targets have most predictive power.

  • iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

    iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

  • HHV-6 linked to miscarriage through Mendelian randomization studies

    The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.

  • Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

    Could HHV-6B infection exacerbate mitochondrial disease?

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Latest Antiviral Articles

View Post

Short-course foscarnet at an early stage may suppress HHV-6 reactivation following allogenic HCT

In All, Antiviral, Transplant Complications by Kristin LoomisAugust 3, 2023

Observational study suggests that an early one-week treatment at the first sign of viral reactivation may achieve clinical benefits and avoid antiviral toxicity.

View Post

DRESS, a syndrome linked to viral reactivation, may be triggered by several antivirals

In All, Antiviral, Drug Hypersensitivity by Kristin LoomisJuly 3, 2023

Ribavarin, ritonavir, abacavir and lamivudine were the primary triggers.

View Post

Small study finds relatively high foscarnet concentrations in CSF in HHV-6 encephalitis

In All, Antiviral, Encephalitis & Encephalopathy, Transplant Complications, Treatments - Antiviral by Kristin LoomisJuly 3, 2023

CSF foscarnet concentrati.ons were very near IC50 and were followed by sharp reductions in viral load.

View Post

New standardized approach to the evaluation of antivirals for DNA viruses

In All, Antiviral by Kristin LoomisNovember 11, 2018

A new method to assess antiviral activity against DNA viruses has been developed, using automated format and qPCR to measure the accumulation of viral DNA. Of the FDA approved drugs, foscarnet showed the highest selectivity index for HHV-6B.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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