• Possible link between depression and HHV-6 infection in childhood

    Serologic studies of several herpesviruses find that only HHV-6 may be linked to depression.

  • Reactivation of latent herpesviruses and HERVS after mild COVID-19

    Findings are accentuated in people with myalgic encephalomyelitis/chronic fatigue syndrome.

  • Virus specific T cell infusions show promise for preventing HHV-6B reactivation in transplant patients

    Review highlights the importance of cell mediated immunity and the limitations of antivirals, vaccines and immunoglobulin therapy for HHV-6, VZV and HSV.

  • Artesunate compares favorably to herpesvirus antivirals in suppressing HHV-6 and HHV-7

    Non-randomized study finds somewhat more potent reduction of virus in leucocytes over several months of treatment.

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Latest Antiviral Articles

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Short-course foscarnet at an early stage may suppress HHV-6 reactivation following allogenic HCT

Observational study suggests that an early one-week treatment at the first sign of viral reactivation may achieve clinical benefits and avoid antiviral toxicity.

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DRESS, a syndrome linked to viral reactivation, may be triggered by several antivirals

Ribavarin, ritonavir, abacavir and lamivudine were the primary triggers.

View Post

Small study finds relatively high foscarnet concentrations in CSF in HHV-6 encephalitis

CSF foscarnet concentrati.ons were very near IC50 and were followed by sharp reductions in viral load.

View Post

New standardized approach to the evaluation of antivirals for DNA viruses

A new method to assess antiviral activity against DNA viruses has been developed, using automated format and qPCR to measure the accumulation of viral DNA. Of the FDA approved drugs, foscarnet showed the highest selectivity index for HHV-6B.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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