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HHV-6 increases risk of an “idiopathic” pneumonia syndrome after HCT as does murine roseolovirus in a BMT mouse model. Early HHV-6 was also found to increase non-relapse mortality.

In All, Animal Models, Lung Disease, Transplant Complications by Kristin Loomis

Investigators from University of Michigan have demonstrated that murine roseolovirus is a useful homolog for the study of HHV-6 reactivation in lung disease. In a large retrospective study of HCT patients, they also found early HHV-6 reactivation to increase the risk of both idiopathic pneumonia syndrome and non-relapse mortality.

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HHV-6 is by far the most common virus found in the spinal fluid of transplant patients with CNS disorders

In All, Encephalitis & Encephalopathy, Transplant Complications by Kristin Loomis

A 73% of 165 hematopoietic stem cell transplant patients tested for possible encephalitis were positive for HHV-6 in a recent review. Only 10% were positive for EBV and no other virus was positive in more than 3% of cases. The outcome for patients with viral infection was poor with 50% mortality within 6 months and only 30% survival at 5 years.

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HHV-6 is a greater risk than CMV for rejection in pediatric kidney transplantation

In All, Kidney Disease, Transplant Complications by Kristin Loomis

Investigators from the Children’s Hospital of Mexico found that although CMV caused the biggest increase in risk for liver rejection, HHV-6 was the more important infection associated with rejection of kidney transplants. A single HHV-6 infection resulted in an increased risk of over 5 fold, while a coinfection of EBV, HHV-6 and HHV-7 increased the risk of kidney rejection by over 17 fold.