Decreased HHV-6 IgG in Alzheimer’s

In All, Alzheimer's Disease, CNS Disease, CNS Dysfunction, Cognitive Dysfunction by Kristin Loomis

Investigators from Uppsala University in Sweden found that HHV-6 IgG reactivity was  significantly lower in Alzheimer’s Disease patients compared to controls.  The authors suggest  reduced immunity may be one reason why past studies have found increased levels of HHV-6 DNA in the brains of Alzheimer Disease (AD) patients compared to controls.

Studies of postmortem brain tissue in AD patients have found an increased prevalence of HHV-6. Elevated rates of HSV1 DNA has also been found in  patients carrying a specific ApoE genotype (Lin 2002 ).  Serum from fifty Alzheimer Disease (AD) patients and 52 controls was analyzed in a multiplex assay for reactivity to four viruses and unlike HHV-6. Although the HHV-6 IgG response was abnormally low, there was no difference was found for HSV1, varicella virus or cytomegalovirus reactivity.

If this impaired humoral immunity against HHV-6  causes increased HHV-6 reactivation in the brain tissue, the impact is localized because there was no difference in the low level latent HHV-6B virus found in PBMCs in patients compared to  controls. This result did not agree with a previous study by Carbone et al that found HHV-6 DNA more frequently in AD patients (23%) compared to controls (4%). The Carbone study also found an increased risk of progression to AD in patients positive for HHV-6 DNA in peripheral blood at baseline (Carbone 2014).

The authors note that  further study is necessary to determine whether HHV-6 might be involved in the pathogenesis of AD.

Read the full paper: Westman 2017