Findings suggest role in evading host immune defenses.
EBV DNA found in 42% of lupus patients compared to 3% of controls; 25% had EBV IgM antibodies compared to <1% of controls
HHV-6 DNA is not elevated in lupus patients but may have a role in reactivating EBV.
Review of the theory that chronic viral infection of the brain can lead to depression
Role of several viruses, including HHV-6A/B, in stimulating low-grade neuroinflammation.
Short-course foscarnet at an early stage may suppress HHV-6 reactivation following allogenic HCT
Observational study suggests that an early one-week treatment at the first sign of viral reactivation may achieve clinical benefits and avoid antiviral toxicity.
COVID-19 patients with HHV-6 DNA and CNS symptoms showed increased expression of miR-155
Both HHV-6 and specific microRNAs may correlate with neurological symptoms in COVID-19.
Accurate Multiplex Assay for Viral Causes of Vesicular Diseases
Assay for monkeypox virus, HSV1-2, HHV-6, VZV and enteroviruses.
Herpesvirus Reactivation Common in Severe COVID-19
HHV-6 was the most common herpesvirus found when tested in nasal swabs, but EBV was the most common in plasma.
Systematic review of pityriasis rosea following COVID-19 and/or vaccination
Pityriasis rosea was reported more frequently after vaccination than during or after acute infection.
HHV-6 DNA load in whole blood and elevated EBNA antibodies predict progression in first clinical episodes of demyelination in multiple sclerosis
Patients with viral loads suggestive of iciHHV-6 had the greatest risk of developing demyelinating disease.
Systematic review: HHV-6 causes 77% of encephalitis cases in hematopoietic cell transplant patients, with a high mortality rate
1.1% of 72,423 HCT patients developed encephalitis with an all-cause mortality rate of 60%.
12th International Conference on HHV-6 & 7 Announced
The 12th International Conference on HHV-6 & 7 will convene in Japan at the Himeji Culture and Convention Center in March 2025.
Differentiating incidental from disease-causing HHV-6 infections in pediatric spinal fluid samples
Clinical assessment revealed that 91% of iciHHV-6 cases and 33% of non-iciHHV-6 cases were incidental.
BioFire assay identifies HHV-6 as the most frequent cause of meningoencephalitis in infants 4-11 months
All cases found to be iciHHV-6 were assumed to be false positives.
High levels of HHV-6A DNA found in blood of 52% of kidney transplant patients
HHV-6A was the most common virus identified, but was not linked to worse outcomes compared to other viral infections.
A tribute to Dharam Ablashi
The HHV-6 field has lost a pioneer.