• Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID

    Autoantibodies directed against neural targets have most predictive power.

  • iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

    iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

  • HHV-6 linked to miscarriage through Mendelian randomization studies

    The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.

  • Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

    Could HHV-6B infection exacerbate mitochondrial disease?

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Latest HHV-6 Research Articles

View Post

Single-cell RNA sequencing was used to determine the tropism of MRV in the thymus and how central tolerance is disrupted

In All, Animal Models, Autoimmune Disease, Genes by Kristin LoomisOctober 30, 2024

A new cell culture model for MRV could offer insights on the development of autoimmunity after neonatal infection.

View Post

A systematic review and meta-analysis confirms an association between HHV-6B reactivation and increased mortality after hematopoietic cell transplant

In All, CNS Disease, Encephalitis & Encephalopathy, Transplant Complications by Kristin LoomisSeptember 16, 2024

Randomized trials are warranted to evaluate if treating HHV-6B reactivation improves outcomes.

View Post

Large study from China identifies adverse outcomes associated with, and risk factors for, HHV-6 encephalitis in post-HSCT patients

In All, CNS Disease, Encephalitis & Encephalopathy, Transplant Complications by Kristin LoomisSeptember 16, 2024

Greatly increased risk of death, acute GVHD, transplant-associated microangiopathy found.

View Post

After screening 100,000 compounds, Merck identified a potent broad-spectrum herpesvirus antiviral

In All, Treatments - Antiviral by Kristin LoomisSeptember 16, 2024

The new small molecule non-nucleoside inhibitor was effective in both in vitro and in vivo studies although no testing against HHV-6 was reported.

View Post

Although 28% of children undergoing chemotherapy develop herpesvirus viremia, there is minimal clinical impact

In All, Cancer, Fever, Lymphadenopathy by Kristin LoomisSeptember 16, 2024

HHV-6, CMV and HSV1/2 were the most likely to reactivate, but herpesvirus reactivation was just as likely prior to chemotherapy.

View Post

Lower levels of torque teno virus correlate with higher HHV-6A viral loads and higher rejection rates in kidney transplantation

In All, Kidney Disease, Transplant Complications by Kristin LoomisSeptember 16, 2024

Value of this observation in determining prognosis or guiding treatment remains to be studied.

View Post

How frequent are HHV-6-related complications with CAR-T cell therapy?

In All, Cancer, Transplant Complications by Kristin LoomisSeptember 3, 2024

A combination of studies find that both reactivation and disease are infrequent after CAR-T therapy.

View Post

Febrile status epilepticus in infants with MRI-confirmed brain abnormalities linked to temporal lobe epilepsy later in life

In All, CNS Disease, Epilepsy and Seizures by Kristin LoomisSeptember 3, 2024

Surprisingly, although HHV-6B has been linked to febrile seizures, febrile status epilepticus and temporal lobe epilepsy, the report contains no mention of the virus.

View Post

HHV-6 & acute pediatric hepatitis of unknown cause: Japan’s experience

In All, Gastrointestinal by Kristin LoomisSeptember 3, 2024

Adeno-associated virus (AAV) linked to Japanese cases, but whether HHV-6 was a cofactor is uncertain.

View Post

HHV-6 found to be possible etiologic agent in some cases of acute hepatitis of unknown origin

In All, Gastrointestinal by Kristin LoomisSeptember 3, 2024

Israeli study of 20 pediatric cases occurring in 2021 found more evidence for HHV-6 than for other viruses, including AAV2 and SARS-CoV-2.

View Post

Centrilobular necroinflammation associated with pediatric HHV-6+ acute liver failure

In All, Gastrointestinal, Transplant Complications by Kristin LoomisSeptember 3, 2024

Would early treatment with antiviral therapy prevent the need for a liver transplant?

View Post

Co-infection of HHV-6A and EBV results in a 6.7 fold increased risk of developing multiple sclerosis

In All, Autoimmune Disease, CNS Disease, Multiple Sclerosis by Kristin LoomisJune 24, 2024

The increased risk occurred only in adults who were infected with EBV after their teenage years, and had elevated EBNA-1 antibodies.

View Post

Why does substituting CMV-specific letermovir for broad-spectrum anti-viral prophylaxis reduce the rate of HHV-6B encephalitis?

In All, Transplant Complications, Treatments - Antiviral by Kristin LoomisJuly 29, 2024

Japanese study replicates the paradoxical results of a prior US study, but fails to explain the paradox.

View Post

Antibodies to HHV-6 and HHV-6 dUTPase are strong predictors of Long COVID

In All, CNS Disease, ME/CFS by Kristin LoomisJuly 29, 2024

CRP and IgA antibodies to activin-A are also important predictors.

View Post

New mechanism identified by which HHV-6B evades NK cell recognition

In All, Genes, Immunity & Immunotherapy by Kristin LoomisJuly 29, 2024

HHV-6B U20 protein inhibits NK cell attacks on virally-infected cells.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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