Expression pattern of several miRNAs in SS tissue parallels the pattern generated when dermal fibroblasts and endothelial cells are infected by HHV-6A and CMV.
Metformin reduces HHV-6A replication in T cells by activating AMPK
Conversely, HHV-6A infection increases viral replication by inhibiting AMPK and enhancing mTOR signaling and glycolysis.
Could HHV-6 reactivation in drug hypersensitivity trigger fulminant type 1 diabetes?
Small study demonstrates increased HHV-6 antibodies in all patients shortly before the onset of DIHS-associated fulminant diabetes.
HHV-6B DNA associated with worse clinical outcomes in high grade serous epithelial ovarian cancer
Multiplex assay for 113 viruses in tumor tissue finds six viruses, including HHV-6B, linked to reduced overall survival.
Reactivation of a transplant recipient’s iciHHV-6B resulted in an active infection of his donated liver
Investigators from the University of Helsinki used highly sophisticated techniques to establish that the donor’s integrated virus reactivated and then infected the graft. This thorough investigation highlights the potential pathological impact of iciHHV-6B in transplantation.
Biofire multiplex PCR assay accurately detects HHV-6 meningitis/encephalitis in immunocompromised adults
Utility of the assay in immunocompetent patients requires further study.
Could a specific polymorphism in HHV-6B partially explain the heritability of major depression?
Individuals carrying this polymorphism had a five-fold increased risk of depression and were more likely to have a family member with major depression.
HHV-6A infection of thyroid cancer cells induces various growth-promoting changes
Oncogene activation, pro-inflammatory cytokines, genomic instability, expression of oncogenic miRNAs are induced by infection.
Reactivated HHV-6, CMV, adenovirus and BK virus associated with increased mortality in pediatric sepsis
Odds of mortality were 2.6-3X higher in patients with detectable viral DNA; odds were even higher with multiple herpesviruses.
Japanese study confirms cognitive problems from post-transplant HHV-6B reactivation
Those with the highest viral loads suffered deficits in verbal memory and reduced quality of life.
Antibodies to a protein specific to latent HHV-6B linked to ulcerative colitis flares
Patients with elevated levels of antibodies to novel biomarker SITH-1 were significantly more likely to have disease activity.
HHV-7 found in the bronchial lavage of 6.2% of Chinese patients with severe pneumonia
It is unknown whether high viral loads correlate with worse prognosis.
First careful characterization of rash in immunocompetent adults with HHV-7 viremia
A distinctive maculopaular pattern involving the acral areas and sometimes the trunk.
Review: meningitis from HHV-7 appears clinically similar to that from HHV-6B, but less frequent
Of 32 patients, two had ocular complications and three had cerebral venous thrombosis.
Adding antithymocyte globulin to post transplant cyclophosphamide prophylaxis does not increase risk of HHV-6 reactivation after haploidentical hematopoietic cell transplantation
The main risk factor for HHV-6 reactivation was low absolute lymphocyte count.