Ribavarin, ritonavir, abacavir and lamivudine were the primary triggers.
Small study finds relatively high foscarnet concentrations in CSF in HHV-6 encephalitis
CSF foscarnet concentrati.ons were very near IC50 and were followed by sharp reductions in viral load.
Single cell transcriptomics of iciHHV-6 cell lines immortalized by EBV infection
Transcription of HHV-6 genes was rare, but occurred most often in cells with the highest levels of EBV transcription.
Are herpesviruses reactivated more often in acute COVID-19?
Systematic review and meta-analysis found strong evidence for EBV in the seriously ill; only 6 of 36 studies included HHV-6 testing.
Using CRISPR to excise integrated HHV-6A from latently infected cells and iciHHV6 patient cell lines, in vitro
Advance may aid the study of integration and excision and might ultimately have clinical application.
Coinfection of CMV and HHV-6A boosts fibrosis-associated microRNAs in fibroblasts
Investigators see possible links to systemic sclerosis, liver fibrosis and cardiovascular remodeling.
Severe hepatitis in young children has novel viral cause
Adeno-associated virus2 plus coinfecting adenoviruses and possibly HHV-6 revealed as causes.
The relationship of telomere length to HHV-6 integration
Telomere length does not appear to influence the efficiency of viral integration, and viral integration may not affect telomere length.
Uncontrolled evidence suggests immunosuppression may be safe and effective in lymphocytic myocarditis patients with biopsies positive for HHV-6 by qPCR
Steroids reduced cardiac inflammation in 70% and improved ejection fraction in 80% without an increase in viral load.
German HCT specialists call for iciHHV-6 screening of patients and donors
Study finds value in HHV-6 testing of other tissues, as well as blood, and of routine testing for iciHHV-6 in both donors and recipients of allo-HCT.
Stanford WGS study: Widespread integration and reactivation of HHV-6B and HHV-7 in lymphoblastoid cells immortalized with EBV
EBV infected B cells may represent a site of HHV-6 latency.
Individuals seropositive for herpesviruses may have greater risk of dementia
Large study from UK Biobank finds that people seropositive for all of these four herpesviruses—HSV-1, HHV-6, HHV-7 and VZV—have greatly increased risk of developing dementia.
Parvovirus B19 and HHV-6 in biopsies of South African patients with acute myocarditis
Parvovirus B19 was the most common virus found, followed by EBV and HHV-6.
Coronary artery spasm often occurs in myocarditis cases with biopsy-proven HHV-6 and parvovirus B19 infection
Both viruses were associated with large vessel spasm, but parvovirus B19 was also associated with microvascular spasm.
Evidence for viral myocarditis in 2.3% of infant sudden death cases
Enteroviruses and parvovirus B19 were found more frequently than HHV-6.