• Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID

    Autoantibodies directed against neural targets have most predictive power.

  • iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

    iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

  • HHV-6 linked to miscarriage through Mendelian randomization studies

    The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.

  • Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

    Could HHV-6B infection exacerbate mitochondrial disease?

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Latest Genes Articles

View Post

Using CRISPR to excise integrated HHV-6A from latently infected cells and iciHHV6 patient cell lines, in vitro

In All, Genes, Latest Scientific News by Kristin LoomisMay 21, 2023

Advance may aid the study of integration and excision and might ultimately have clinical application.

View Post

Differentially expressed HHV-6A/B and HHV-7 genes may have prognostic value in gliomas

In All, Cancer, Genes by Kristin LoomisFebruary 20, 2023

Unclear if viral gene expression signature confers prognostic information that is independent of host cell gene expression signatures.

View Post

Two HHV-6 genes may contribute to pathogenesis of autoimmune thyroiditis

In All, Autoimmune Disease, Endocrine Conditions, Genes by Kristin LoomisOctober 21, 2022

Genes U12 and U51 encode homologues of human G-protein-coupled receptors, and are potential triggers of autoimmunity.

View Post

Does inherited chromosomal integration of HHV-6 at 9q increase the risk of malignancy?

In All, Cancer, Genes, Latest Scientific News by Kristin LoomisSeptember 26, 2022

A large study of iciHHV-6 integration sites found integration at 9q more common in hematologic malignancies—but the study lacked power to draw firm conclusions.

View Post

Development of highly sensitive technique for detecting viral DNA sequences in cell-free plasma

In All, Genes, Latest Scientific News by Kristin LoomisSeptember 26, 2022

Isolating DNA fragments less than 120 base pairs enriches for viral vs. cellular DNA.

View Post

G-1082A polymorphism of IL-10 may protect against HHV-6/EBV adenoid hypertrophy

In All, Genes, Latest Scientific News, Lymphadenopathy by Kristin LoomisSeptember 26, 2022

The presence of HHV-6 and EBV DNA in nasal secretions correlates with the degree of adenoid hypertrophy in children.

View Post

HHV-6A U14 protein and NFκB activate each other

In All, Genes, Latest Scientific News by Kristin LoomisAugust 15, 2022

The late protein U14 of HHV-6A can induce the pro-inflammatory transcription factor NFκB, and NFκB, in turn, can encourage the replication of HHV-6A.

View Post

Different isoforms of CD46 affect infectivity and replication of HHV-6A and HHV-6B

In All, Genes, Latest Scientific News by Kristin LoomisAugust 15, 2022

While CD134 remains the more important receptor for HHV-6B, HHV-6B can use the CD46 receptor when a T cell has the C1 isoform of CD46.

View Post

HHV-6B may enter cells that don’t express CD134 via the nectin-2 receptor

In All, Genes, Latest Scientific News by Kristin LoomisAugust 15, 2022

If confirmed, finding could explain ability of HHV-6B to infect salivary, liver and neural cells.

View Post

Modulation of HHV-6B and HHV-6A infection and gene expression by CD9

In All, Genes by Kristin LoomisJuly 12, 2022

The tetraspanin CD9 promotes CD46-dependent cellular infection by HHV-6A and impairs CD46-independent infection by HHV-6B.

View Post

The U20 and U21 genes of HHV-6A downregulate NK cell attack

In All, Genes by Kristin LoomisJune 16, 2022

U20/21 genes may help HHV-6A evade immune response

View Post

4C-seq genomic methodology used to examine HHV-6A integration sites

In All, Genes, iciHHV-6, Latest Scientific News by Kristin LoomisMay 20, 2022

Chromatin interactions help silence transcription of HHV-6A genes following integration

View Post

Updated mapping and proposed new annotation of the HHV-6B transcriptome

In All, Genes, Latest Scientific News by Kristin LoomisApril 4, 2022

An analysis of the kinetics of gene expression during infection of human Molt-3 T-cells agrees with previous studies, but also demonstrates unique findings.

View Post

A large scale whole genome sequencing study sheds light on HHV-6 integration events

In All, ciHHV-6, Genes, iciHHV-6, Latest Scientific News by Kristin LoomisApril 4, 2022

Investigators at the Riken Institute in Japan developed new computational methods to detect virus induced structural variants in the human genome

View Post

A comprehensive review of the role and potential functions HHV-6A/B U94

In All, Autoimmune Disease, Genes, Latest Scientific News by Kristin LoomisMarch 1, 2022

The review covers the role the U94 gene product plays in the virus’s life cycle, replication, and latency, as well as in the immune response.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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