Chromatin interactions help silence transcription of HHV-6A genes following integration
HHV-6B infection of primary monocytes induces cell-associated and soluble PD-L1 production, increased intracellular ROS and activation of STAT1 and STAT3 pathways
The combination of gQ1 and gQ2 tetramer components of both HHV-6A/6B are important for viral propagation, probably by affecting attachment to their different receptors.
Early infection interferes with normal thymocyte development and disrupts central tolerance resulting in autoimmune disease later in life. Only infection during this critical time period resulted in autoimmunity.
An analysis of the kinetics of gene expression during infection of human Molt-3 T-cells agrees with previous studies, but also demonstrates unique findings.
Investigators at the Riken Institute in Japan developed new computational methods to detect virus induced structural variants in the human genome
Using whole genome optical mapping, investigators found that contrary to previous findings, the length of telomeres with viral integration was not unusually short.
The review covers the role the U94 gene product plays in the virus’s life cycle, replication, and latency, as well as in the immune response.
HHV-6, like some other herpesviruses, dysregulates autophagy in multiple cell types, with important biological consequences.
A small study found a strong association between HHV-6 infection of the placenta and intrauterine growth restriction—a finding consistent with other evidence linking HHV-6 to several reproductive diseases.
CD45, important in T cell receptor signaling, may be one mechanism by which roseolaviruses evade immune detection and help achieve latency
Cytokine and chemokine responses were very similar in HHV-6B and HHV-7 infections. The results were starkly different for HHV-6A.
Keith Jerome and Alex Greninger’s virology lab at University of Washington was one of the first in the nation with a test for SARS CoV-2 and they are credited with helping to identify the first confirmed US case of the virus in January. Keith Jerome, MD, PhD, Director, and Alex Greninger, MD, PhD, Assistant Director of the University of Washington …
Hundreds of new open reading frames were identified in a comprehensive Weizman Institute study that has generated a complete, unbiased atlas of the HHV-6A/B proteome.
A comprehensive study of DNA and RNA-Seq data demonstrated in vivo gene expression in many iciHHV-6 tissues, with strong expression of IE-1 and matching elevated antibody response in iciHHV-6 individuals compared to controls.