New study shows HHV-6 may induce demyelination through both B and T-cell reaction. HHV-6 oligoclonal bands were also found in cases of clinically isolated syndrome.
Dr. Louis Flamand’s laboratory in Quebec, Canada, has published an article with evidence that points toward a detailed mechanism for inhibition of IL-2 gene expression by HHV-6.
Italian study finds 62% of women who developed PR early in their pregnancies miscarried
After discovering a novel human receptor (CD134) used by HHV-6B for cellular entry last year, Dr. Yasuko Mori’s group at Kobe University Graduate School of Medicine in Japan has released additional details regarding the interaction of HHV-6B its newly described receptor.
Seattle group announces the discovery of novel HHV-6 and HHV-7 homologs in pig-tailed macaques
A group of investigators in Japan have determined that HMGB-1, an inflammatory cytokine released in response to trauma, stress, and surgery, is highly elevated in DIHS/DRESS patients.
A group from Japan has conducted a retrospective study of 130 patients who underwent stem cell transplantation in an attempt to identify a risk factor for the development of encephalopathy.
HHV-6 encephalitis as a trigger in children with POLG mitochondrial disorders? Two cases of fatal Alpers-Huttenlocher syndrome
HHV-6A major capsid protein identified in CSF of MS patients: a case of molecular mimicry?
Two papers published this month highlight the potential of the new 3rd generation PCR assays in the field of HHV-6 diagnostics.
New model of HHV-6A infection demonstrates persistent abortive infection and neuroinflammation via TLR9
Dr. Hollsberg’s team at Aarhus University in Denmark has identified the protein responsible for this crucial mechanism of cell-cycle specific interruption.
While elevated TNF-a detected at the early onset of disease is a strong indicator for the early recognition of HHV-6 reactivation, this finding also reflects important therapeutic information that could be used as an early diagnostic marker of DIHS/DRESS.
Branka Horvat, MD, PhD, Director of Research at the International Centre for Infectiology Research in Lyon, France (INSERM), and her doctoral student Josephine Reynaud have recently published an important paper on a new transgenic mouse model
Additional evidence that shortened telomeres can cause the release and possible activation of integrated HHV-6.