Utility of the assay in immunocompetent patients requires further study.
Could a specific polymorphism in HHV-6B partially explain the heritability of major depression?
Individuals carrying this polymorphism had a five-fold increased risk of depression and were more likely to have a family member with major depression.
Japanese study confirms cognitive problems from post-transplant HHV-6B reactivation
Those with the highest viral loads suffered deficits in verbal memory and reduced quality of life.
MS drug teriflunomide dramatically reduces antibody titers to EBV and HHV-6
Study results are consistent with a pathogenetic role for viruses in relapsing-remitting MS.
Growing evidence of rare HHV-7 associated encephalitis and seizures in the immunocompetent
The clinical picture is very similar to HHV-6B encephalitis.
New Evidence that HHV-6A, like EBV, May Trigger Some Cases of Multiple Sclerosis (MS)
Sera drawn before vs. after onset of MS find seropositivity for HHV-6A more likely in MS.
Meta-Analysis links EBV, HHV-6 and VZV to multiple sclerosis
Study pools data from nearly 30,000 people with MS.
Higher HHV-6 viral load in oral mucosa cells in people with major depression
Combination of viral load and presence of specific polymorphism in the TNF-α gene associated with major depression.
Review of the theory that chronic viral infection of the brain can lead to depression
Role of several viruses, including HHV-6A/B, in stimulating low-grade neuroinflammation.
HHV-6 DNA load in whole blood and elevated EBNA antibodies predict progression in first clinical episodes of demyelination in multiple sclerosis
Patients with viral loads suggestive of iciHHV-6 had the greatest risk of developing demyelinating disease.
BioFire assay identifies HHV-6 as the most frequent cause of meningoencephalitis in infants 4-11 months
All cases found to be iciHHV-6 were assumed to be false positives.
Individuals seropositive for herpesviruses may have greater risk of dementia
Large study from UK Biobank finds that people seropositive for all of these four herpesviruses—HSV-1, HHV-6, HHV-7 and VZV—have greatly increased risk of developing dementia.
Herpesvirus reactivation during alloHSCT associated with greatly increased mortality and expense
Data from 13,363 transplant patients underline the importance of preventing, diagnosing and treating viral reactivation.
Another report links HHV-6B nucleic acid and antigen to mesial temporal lobe epilepsy
Viral DNA and antigen found at higher levels in MTLE than in control brains.
HHV-6 DNA often found in cerebrospinal fluid in samples tested for meningitis
Those with viral infections showed no difference in white or red blood cell counts or the protein and glucose levels.