Previous Studies funded by the HHV-6 Foundation

2017
MicroRNAs of HHV-6 in serum and cerebrospinal fluid of multiple sclerosis patients: correlation with activity and progression of the disease Roberto Alvarez-Lafuente, MD, Hospital Clinico San Carlos, Madrid, Spain
HHV-6 induced alterations of microRNAs and transcriptional factors expression: focus on autoimmunity Elisabetta Caselli, PhD, University of Ferrara, Ferrara, Italy
Autophagy Interaction with HHV-6A Infection Mara Cirone, PhD, La Sapienza University of Rome, Rome, Italy

Prevalence of Human Herpesvirus 6 and Cytomegalovirus in Pediatric Heart Transplant Recipients with Cardiac Allograft Vasculopathy

Cardiotropic Viral Infections in Children with Dilated Cardiomyopathy and Clinical Significance of Pretransplant

Chromosomally Integrated Human Herpesvirus-6 in Heart Transplant Recipients

 Bibhuti Das, MD, University of Texas Southwest Medical Center, Dallas, Texas
Human herpesvirus 6B affects the MAPK pathway, possibly involved in vacuolization of infected cells Elin Engdahl, PhD, Karolinska Institute, Stockholm, Sweden
Induced pluripotent stem cells to study the biological impacts of inherited chromosomally-integrated HHV-6 Louis Flamand, PhD, Laval University, Québec City, Canada
Cancer Risk and Inflammatory Profile in Patients with Inherited Chromosomally Integrated Human Herpesvirus 6 Joshua A. Hill, MD, Fred Hutchinson Cancer Research Center, Seattle, Washington
The Role of Human Herpesvirus 6 in Salivary Gland Cancer David Hudnall, MD, FCAP, Yale University School of Medicine, New Haven, Connecticut
Characterisation of iciHHV-6 integration sites using targeted enrichment coupled with sequencing on the Oxford Nanopore Technologies platform Ruth Jarrett, MD, University of Glasgow, Glasgow UK
Do donor T cell responses to HHV6B predict reactivation after hematopoietic stem cell transplantation? David Koelle, MD, University of Washington, Seattle, Washington
HHV-6 A/B infection and Multiple sclerosis: triggering factor or epiphenomenon?  Mauro Malnati, MD, PhD. San Raffaele Scientific Institute, Milan, Italy
In vitro studies on the effect of Avemar on Roseoloviruses Joseph Ongradi, PhD, Semmelweis University, Budapest, Hungary
Assessment of the effects of HHV-6A infection on the endometrial (e)NK cells of infertile women Roberta Rizzo, PhD, University of Ferrara, Ferrara, Italy
Investigating the potential link between HHV-6B and MS: interaction between U24 and WW domains. Suzana Straus, PhD, University of British Columbia, Kelowna, Canada
Defining how HHV-6 Induces Mitochondrial Dysfunction and Metabolic Alterations in Human T-lymphoblast Lines Phillip West, PhD, Texas A&M, College Station, Texas
Role of shelterin in HHV-6 integration and its association with disease in iciHHV-6 individuals Darren Wight, PhD, Freie Universität Berlin, Berlin, Germany
A Mouse Model of HHV-6 Reactivation Post Allogeneic HSCT Xiofeng Zhou, PhD, Unversity of Michigan, Ann Arbor, Michigan
2016
Human herpesvirus 6B induced hypomethylation on chromosome 17p13.3 Elin Enghdahl, Karolinska Institute
HHV-6 infection in patients after allogeneic HSCT Raffaella Greco, MD, San Raffaele Scientific Institute, Milano, Italy
2015
ciHHV-6 activation in response to drugs Bhupesh Prusty, PhD, University of Würzburg
2014
Chromosomal integration in HSCT patients Vicki Boussiotis, MD. PhD, Beth Israel Deasoness Medical Center
HHV-6 in Gliomas Nanjing Medical University
Exploration of ciHHV6 in the Generation Scotland dataset Ruth Jarrett, University of Glasgow
2013
HHV-6 in Post Transplant Limbic Encephalitis Joshua Hill, Fred Hutchinson Cancer Research Center
Detection of HHV-6 in Children with Epilepsy Tobias Loddenkemper, MD, Boston Children’s Hospital
HHV-6A genomic integration in Zambia and infant development Gompels, London School of Hygiene & Tropical Medicine
2012
HHV-6 infection and ciHHV-6 in cord blood transplantation Anoma Nellore, Beth Israel Deaconness Medical Center
HHV-6 and parvovirus B19 co-infection in a wide variety of human diseases and cancer Jacqueline Hobbs, University of Florida College of Medicine
HHV-6 genomic integration in Zambia and infant development Ursula Gompels, University of London School of Hygiene and Tropical Medicine
HHV-6 in Hodgkin’s Lymphoma Ruth Jarrett, University of Glasgow Center for Virus Research
2011
Efficacy of antiviral drug treatment of HHV-6 infection Peter Medveczky, University of South Florida
Development of Humanized Rag2-/-gc-/- Mice as a model of HHV-6A infection Bradford Berges, Brigham Young University
The contribution of neuroinflammatory responses to HHV-6B/HHV-7 infection in the pathogenesis of mesial temporal lobe epilepsy Jin Mei Li & Dong Zhou, West China Hospital & Sichuan University
HHV-6 in adult and pediatric brain tumors Michael Scheurer, Dan L. Duncan and Texas Children’s Cancer Centers, Baylor College of Medicine
Prevalence and significance of ciHHV-6 infection in liver transplant recipients Raymund Razonable, Division of Transplant and Infectious Diseases, Mayo Clinic
2010
Study of Chromosomally Integrated HHV-6 Subjects Prior and Post Valcyte Treatment Daniel Peterson, Simmaron Research
The role of HHV-6 in pediatric convulsions of unknown cause Ankrah Lennox-Mac, Department of Microbiology, University of Ghana Medical School
Development of an improved TCID50 assay for HHV-6A Rasmus Gustafsson, The Karolinska Institute, Sweden
Human Herpesvirus-6, dendritic cells and TH17 Anshu Agrawal, University of California at Irvine
The role of U94/rep gene and TTAGGG telometric repeats of HHV-6 in integration in human chromosomes Peter Medveczky, University of South Florida
The Functional Characterization of HHV-6/U94 Gene Product Louis Flamand, Centre Hospital University de Quebec
2009
Anti-HHV-6 activity of the broad antiinfective drug artesunate: investigation of the mode of action Jens Milbradt & Manfred Marschall, Institute for Clinical and Molecular Virology, Erlangen Medical Center, Germany
Adoptive T cell Immunotherapy to Prevent or Treat HHV-6 Ulrike Gerdeman, Center for Cell & Gene Therapy, Baylor University
XMRV, HHV-6, EBV & Endogenous retroviruses in patients with CFS Brigitte Huber, Tufts University
2008 and Beyond
HHV-6 Specific CD8+ T cell Responses Sudhir Gupta, MD, PhD, MACP University of California Irvine, California USA
Development of a Variant-specific, Calibrated Real-time PCR Assay for the Absolute Quantification of HHV-6A and B Nucleic Acids in Clinical Samples Mauro S. Malnati, MDSan Raffaele Scientific InstituteMilan, Italy USA
The Human Herpesvirus 6A U45 Gene Product: Role in Immune Dysfunction Marshall Williams, PhDOhio State University, USA
Variant Specific PCR ELISA Yi-Wei Tang, MD, PhDVanderbilt University, USA
Determination of the chromosomal integration of the HHV-6 virus in highly seropositive Chronic Fatigue Syndrome patients Daniel L. Peterson, MD, Sierra Internal Medicine, Nevada, USA
The role of chronic immune stimulation by active herpesvirus 6 (HHV-6) infection/coinfections in immune dysfunction and development of lymphoma Daniel L. Peterson, MD, Sierra Internal Medicine, Nevada, USA
Investigation of inhibitory effects of the multipotent drug Artesunate against HHV-6 Manfred Marschall, PhDUniversität Erlangen-Nürnberg, Germany
Creation of a humanized CD46 mouse model for HHV-6 infection Claude P. Genain, MDCalifornia Pacific Medical Center Research Institute, San Francisco USA
Study of HHV-6 & EBV in patients with CNS Dysfunction and long-standing fatigue Jose Montoya, MDStanford University, USA
Use of recombinant viral proteins for the identification of active HHV-6 infection by serological assays. Louis Flamand, PhD,Universite Laval, Quebec, Canada, USA
Cloning the HHV-6 A and B genome for the identification of genes responsible for pathogenicity Peter Medveczky, MD, University of South Florida, College of Medicine, USA
A study of incidence of ciHHV-6 in children with congenital infection of HHV-6 Carolyn Hall, MDUniversity of Rochester
Study of HHV-6B in Mesial Temporal Lobe Epilepsy Nihal De Lanerolle, MD, PhDYale University, MD, PhD
ciHHV-6 FISH analysis Peter Ambros, PhDChildren’s Cancer Research Institute
HHV-6 activation of HERV K18 Brigitte Huber, PhdTufts University