The HHV-6 Foundation has developed this mAb, with the help of Louis Flamand, PhD and it is now available at the Foundation Repository. This oncoprotein mAb has been tested by numerous scientists and appears to be better than antibodies against other proteins for detecting the presence of HHV-6 in tumors. It works for immunohistochemistry as well as western blots and detects both HHV-6A and HHV-6B.
The DR-7 oncoprotein was used to identify HHV-6 in the Reed-Sternberg cells of Hodgkin’s lymphoma tumors, primarily in the nodular sclerosis subset, by Lacroix et al in 2010. In 2012, Professor David Hudnall’s group at Yale confirmed that HHV-6B was localized in Reed-Sternberg cells in the nodular sclerosis subset of Hodgkin’s lymphomas (Siddon 2012). HHV-6 has been found in many tumors including Hodgkin’s and non-Hodgkin’s B-cell lymphomas, brain tumors, oral carcinomas, cervical carcinomas, and pituitary tumors.
See our repository page to obtain this reagent free of charge.