A group from France has reported new findings which may help explain the mystery behind the increased rates of HHV-6 reactivation and encephalitis observed among umbilical cord blood transplant (CBT) patients.
Bortezomib may increase risk of HHV-6 reactivation in myeloma patients
A new study has reported that the use of Bortezomib, known commercially as Velcade, may increase the risk of HHV-6 reactivation in myeloma patients undergoing stem cell transplantation.
Funding gap! HHV-6 & HHV-7 have received only a fraction of the funding received by EBV, CMV and HHV-8.
Since 2000, NIH has given nearly $1 Billion in total grant funding to study the herpesviruses EBV, CMV, and KSHV, compared to only $15 million to study HHV-6 & HHV-7.
Increased prevalence of HHV-6 antibodies discovered in multiple sclerosis patients
An increased prevalence of HHV-6 U94/REP antibodies found among Tunisian MS patients.
High rate of active HHV-6 detected among patients with cardiac disease
Unusually high rate of active HHV-6 infection detected among hospital patients with cardiac disease.
CMX001 shows strong in-vitro activity against HHV-6
Data from a recent report may increasingly argue in favor of using the antiviral known as CMX001 for treatment of HHV-6 infection.
New HHV-6 species-specific serological assay developed
This new assay will hopefully open the door for increased exploration into the seroepidemiology of HHV-6A and HHV-6B infection.
In Memoriam- Caroline B. Hall Young Investigator Award
The HHV-6 Foundation has established an award in memory and honor of Dr. Caroline Breese Hall, a renowned Pediatric Infectious Diseases physician and expert on HHV-6 who passed away in December 2012.
Further characterization of HHV-6B immune response leads to development of virus-specific immunotherapy
A group from Baylor has further characterized the clinical HHV-6B immune response, and is using this new information to develop an enhanced adoptive T cell immunotherapy specific to HHV-6 for HSCT patients.
HHV-6 induces oxidative stress and chlamydial persistence
Findings indicate that HHV-6 infection leads to decreased glutathione production, increased oxidative stress, and induces chlamydial persistence during co-infection
HHV-6 active replication genetically linked to poor treatment response among MS patients
Strong evidence of a genetic link between HHV-6 active replication and poor IFN-B treatment response among multiple sclerosis patients
HHV-6A linked to Thyroiditis, Autoimmune Disease
A group from Italy has linked HHV-6A to Hashimoto’s Thyroiditis, and provides evidence for autoimmune disease associated with HHV-6A and HHV-6B.
Study finds nearly 10% of cord blood transplant patients develop HHV-6 encephalitis
International group calls for routine HHV-6 surveillance in all cases of UCBT
HHV-6 Latent Infection Identified in Patients with Glioma
Investigators from Nanjing Medical University have found HHV-6 latent infection in glioma tissues, and have isolated a strain of HHV-6A from the glioma cyst.
Group identifies HHV-6B-specific CD8+ T Cell response
A new study from the University of Munchen in Munich, Germany, has identified a subset of CD8+ T cells that specifically recognize HHV-6B and not HHV-6A.