A novel technique has been developed for the treatment of several viral infections–including HHV-6–following HSCT.
Yale study ties HHV-6 to Hodgkin’s lymphoma
A thorough investigation of the association between HHV-6 and Hodgkin’s lymphoma finds the presence of HHV-6 in a majority of nodular sclerosis cases of HL.
HHV-6A and HHV-6B now recognized as two distinct viruses
The International Committee for Taxonomy of Viruses has made it official. HHV-6A and HHV-6B are two distinct viruses, each with their own characteristics and disease associations.
Febrile Status Epilepticus linked to active HHV-6B and HHV-7 infection
A ten-year NIH-funded study has determined that a third of infants with prolonged seizures and fever suffer from either a new or reactivated roseola virus infection.
HHV-6 causes limbic encephalitis in 10% of cord blood transplant patients.
New study from Harvard finds heightened risk of HHV-6 PALE for UCBT patients.
HHV-6 reactivation tied to increased mortality and acute GVHD in HSCT
HHV-6 detection associated with increasingly poor outcome for stem cell transplant patients.
Epilepsy Following HHV-6 Limbic Encephalitis in Pediatric Transplant Patients
A group from the Royal Children’s Hospital in Melbourne, Australia has reported the development of epilepsy after HHV-6 posttransplant limbic encephalitis (PALE) among children receiving stem cell transplantation with cord blood (CBT).
International group of HHV-6 investigators review inherited or “chromosomally integrated” HHV-6 (ciHHV-6)
An international group of HHV-6 experts, investigators and clinicians have published a comprehensive review of chromosomally integrated HHV-6 (ciHHV-6). The article, entitled “Chromosomally Integrated human herpesvirus-6: questions and answers,” is written in response to the widespread confusion in the medical community on how to test or diagnose the condition, as well as how to treat a patient with ciHHV-6 who may or may not have symptoms consistent with HHV-6 reactivation.
Group further characterizes HHV-6 CD4+ T cell response
In a recent publication, investigators from the University of Massachusetts reported the first fine characterization of the CD4+ T cell response to HHV-6.
HHV-6 Reactivation linked to complications in Allogenic Stem Cell Transplantation
Researchers have tied HHV-6 Reactivation to GVHD, seizures, pneumonia, and encephalitis in Allo-SCT patients.
HHV-6 in the liver associated with decreased graft survival
Researchers from the University of Hannover have found a significant association between HHV-6 and decreased graft survival in liver transplant patients.
Case of fatal HHV-6 chronic myocarditis reported in an immunocompetent adult
A group of physicians from the University Hospital in Reims, France, have reported a case of fatal HHV-6 myocarditis in an immunocompetent patient previously thought to be negative for HHV-6 infection.
Two year MS study shows that relapse correlates with HHV-6A reactivation
A new study shows that multiple sclerosis patients with HHV-6 have higher risk of relapse and poor response to IFN-beta treatment.
HHV-6A can travel through the nose to the brain
The trigger for neurological disease in a subset of patients with MS?
Clinical Significance of Pre-Transplant Chromosomally-Integrated HHV-6 in Liver Transplant Recipients
The reactivation of HHV-6 in transplant recipients has long been known to induce clinical complications and poor outcomes following transplantation. However, the clinical relevance of transplant patients with ciHHV-6…