Instead of using the traditional epitope mapping approach to identify major targets of the T cell response to a complex pathogen, a group from the University of Massachusetts used mass spectrometry to identify viral proteins associated with immunodominant antigens.
HHV-6 reactivation reduces CD8+ T cell recovery with increased risk of infections and reduced survival
In a French study of 366 adult allogenic hematopeietic stem cell transplantation (aHSCT) recipients CD8+ T cell recovery was significantly reduced in patients with HHV-6 reactivation. HHV-6 reactivation was also associated with reduced survival and increased infections of CMV and BKV.
HHV-6B-induced neutropenia in primary infection associated with specific chemokines
In an article published in the Pediatric Infectious Disease Journal, Tetsushi Yoshikawa’s team from Fujita Health University School of Medicine determined that the severe neutropenia in primary HHV-6B infection is tied to reduced platelet counts, lower RANTES and higher levels of MCP-1, MIG and IP-10.
HMGB-1 found to be preferentially elevated in DIHS/DRESS: the key to HHV-6 reactivation?
A group of investigators in Japan have determined that HMGB-1, an inflammatory cytokine released in response to trauma, stress, and surgery, is highly elevated in DIHS/DRESS patients.
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