• Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID

    Autoantibodies directed against neural targets have most predictive power.

  • iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

    iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

  • HHV-6 linked to miscarriage through Mendelian randomization studies

    The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.

  • Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

    Could HHV-6B infection exacerbate mitochondrial disease?

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Latest Scientific News Articles

Measles immunosuppression may cause abortive, subclinical reactivation of HHV-6

In All, Latest Scientific News by hhv6foundationJanuary 29, 2014

Dr. Yoshizo Asano and colleagues in Japan report that in measles immunosuppression, cells sensitized to HHV-6B immediate early and early antigen proteins may suppress replication cycles and virus formation, resulting in an “incomplete” subclinical state of reactivation.

New HHV-6 reagent available from The HHV-6 Foundation: DR7 Mab

In All, Latest Scientific News by hhv6foundationJanuary 29, 2014

We are pleased to announce that with the help of a few HHV-6 specialists, especially Prof. Louis Flamand from Canada, we have generated the monoclonal antibody DR-7.

REVIEW: Important differences between the HHV-6A and HHV-6B viruses

In All, Epidemiology, Latest Scientific News by hhv6foundationDecember 22, 2013

An international group of experts summarize the significant differences between the two viruses.

Human herpesvirus replication is activated by apoptosis

In All, Latest Scientific News by hhv6foundationOctober 31, 2013

A group led by Steven Zeichner has published evidence that suggests the replication of all human herpesviruses can be activated by apoptosis.

Humanized mouse model demonstrates HHV-6A infection can cause significant immune dysfunction

In All, Animal Models, Latest Scientific News by hhv6foundationOctober 31, 2013

Could treatment of HHV-6A co-infections slow AIDS progression?

MCP-1 found elevated in the CSF of patients with HHV-6B encephalopathy

In All, Encephalitis & Encephalopathy, Latest Scientific News by hhv6foundationOctober 31, 2013

Japanese group identifies several cytokine and chemokine responses associated with HHV-6B encephalopathy.

HHV-6B infection promotes unique pro-inflammatory effects tied to neurocognitive decline and artherosclerosis

In All, Cognitive Dysfunction, Latest Scientific News by hhv6foundationSeptember 30, 2013

HHV-6A and HHV-6B each express distinct chemokines that are uniquely capable of activating key inflammatory cytokines.

New HHV-6B specific cellular receptor identified

In All, Latest Scientific News by hhv6foundationAugust 30, 2013

CD134, a member of the TNF receptor superfamily, has now been shown as a specific entry receptor for HHV-6B.

Chlamydia infection induces activation of ciHHV-6 leading to linear and circular DNA

In All, ciHHV-6, Latest Scientific News by hhv6foundationMay 6, 2013

A laboratory at the University of Wurzburg has published evidence that Chlamydia trachomatis may induce the activation of ciHHV-6.

Why does HHV-6 reactivate preferentially in CBT?

In All, Latest Scientific News by hhv6foundationJanuary 31, 2013

A group from France has reported new findings which may help explain the mystery behind the increased rates of HHV-6 reactivation and encephalitis observed among umbilical cord blood transplant (CBT) patients.

Bortezomib may increase risk of HHV-6 reactivation in myeloma patients

In All, Latest Scientific News by hhv6foundationJanuary 31, 2013

A new study has reported that the use of Bortezomib, known commercially as Velcade, may increase the risk of HHV-6 reactivation in myeloma patients undergoing stem cell transplantation.

HHV-6 induces oxidative stress and chlamydial persistence

In All, Latest Scientific News, ME/CFS by hhv6foundationNovember 16, 2012

Findings indicate that HHV-6 infection leads to decreased glutathione production, increased oxidative stress, and induces chlamydial persistence during co-infection

Group identifies HHV-6B-specific CD8+ T Cell response

In All, Latest Scientific News by hhv6foundationSeptember 28, 2012

A new study from the University of Munchen in Munich, Germany, has identified a subset of CD8+ T cells that specifically recognize HHV-6B and not HHV-6A.

HHV-6A and HHV-6B now recognized as two distinct viruses

In All, Latest Scientific News by hhv6foundationJuly 18, 2012

The International Committee for Taxonomy of Viruses has made it official. HHV-6A and HHV-6B are two distinct viruses, each with their own characteristics and disease associations.

Group further characterizes HHV-6 CD4+ T cell response

In All, Latest Scientific News by hhv6foundationMarch 1, 2012

In a recent publication, investigators from the University of Massachusetts reported the first fine characterization of the CD4+ T cell response to HHV-6.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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