Individuals carrying this polymorphism had a five-fold increased risk of depression and were more likely to have a family member with major depression.
HHV-6A infection of thyroid cancer cells induces various growth-promoting changes
Oncogene activation, pro-inflammatory cytokines, genomic instability, expression of oncogenic miRNAs are induced by infection.
Reactivated HHV-6, CMV, adenovirus and BK virus associated with increased mortality in pediatric sepsis
Odds of mortality were 2.6-3X higher in patients with detectable viral DNA; odds were even higher with multiple herpesviruses.
Japanese study confirms cognitive problems from post-transplant HHV-6B reactivation
Those with the highest viral loads suffered deficits in verbal memory and reduced quality of life.
Antibodies to a protein specific to latent HHV-6B linked to ulcerative colitis flares
Patients with elevated levels of antibodies to novel biomarker SITH-1 were significantly more likely to have disease activity.
HHV-7 found in the bronchial lavage of 6.2% of Chinese patients with severe pneumonia
It is unknown whether high viral loads correlate with worse prognosis.
First careful characterization of rash in immunocompetent adults with HHV-7 viremia
A distinctive maculopaular pattern involving the acral areas and sometimes the trunk.
Review: meningitis from HHV-7 appears clinically similar to that from HHV-6B, but less frequent
Of 32 patients, two had ocular complications and three had cerebral venous thrombosis.
Adding antithymocyte globulin to post transplant cyclophosphamide prophylaxis does not increase risk of HHV-6 reactivation after haploidentical hematopoietic cell transplantation
The main risk factor for HHV-6 reactivation was low absolute lymphocyte count.
HHV-6B IE1 inhibits DNA damage signaling pathway leading to genomic instability
Results suggest a possible link between genomic instability and iciHHV-6 associated disease.
MS drug teriflunomide dramatically reduces antibody titers to EBV and HHV-6
Study results are consistent with a pathogenetic role for viruses in relapsing-remitting MS.
Synergistic role of HHV-6A U37 and heat shock proteins in viral replication
Findings provide important insights that may reveal potential targets for antiviral therapy.
Growing evidence of rare HHV-7 associated encephalitis and seizures in the immunocompetent
The clinical picture is very similar to HHV-6B encephalitis.
Strong Evidence Linking HHV-6B To Pneumonia in Transplant Patients
Levels of mRNA transcripts indicating active infection strengthen case for pathogenic role.
New Evidence that HHV-6A, like EBV, May Trigger Some Cases of Multiple Sclerosis (MS)
Sera drawn before vs. after onset of MS find seropositivity for HHV-6A more likely in MS.