Observational study suggests that an early one-week treatment at the first sign of viral reactivation may achieve clinical benefits and avoid antiviral toxicity.
COVID-19 patients with HHV-6 DNA and CNS symptoms showed increased expression of miR-155
Both HHV-6 and specific microRNAs may correlate with neurological symptoms in COVID-19.
Accurate Multiplex Assay for Viral Causes of Vesicular Diseases
Assay for monkeypox virus, HSV1-2, HHV-6, VZV and enteroviruses.
Herpesvirus Reactivation Common in Severe COVID-19
HHV-6 was the most common herpesvirus found when tested in nasal swabs, but EBV was the most common in plasma.
Systematic review of pityriasis rosea following COVID-19 and/or vaccination
Pityriasis rosea was reported more frequently after vaccination than during or after acute infection.
HHV-6 DNA load in whole blood and elevated EBNA antibodies predict progression in first clinical episodes of demyelination in multiple sclerosis
Patients with viral loads suggestive of iciHHV-6 had the greatest risk of developing demyelinating disease.
Systematic review: HHV-6 causes 77% of encephalitis cases in hematopoietic cell transplant patients, with a high mortality rate
1.1% of 72,423 HCT patients developed encephalitis with an all-cause mortality rate of 60%.
Differentiating incidental from disease-causing HHV-6 infections in pediatric spinal fluid samples
Clinical assessment revealed that 91% of iciHHV-6 cases and 33% of non-iciHHV-6 cases were incidental.
BioFire assay identifies HHV-6 as the most frequent cause of meningoencephalitis in infants 4-11 months
All cases found to be iciHHV-6 were assumed to be false positives.
High levels of HHV-6A DNA found in blood of 52% of kidney transplant patients
HHV-6A was the most common virus identified, but was not linked to worse outcomes compared to other viral infections.
A tribute to Dharam Ablashi
The HHV-6 field has lost a pioneer.
DRESS, a syndrome linked to viral reactivation, may be triggered by several antivirals
Ribavarin, ritonavir, abacavir and lamivudine were the primary triggers.
Small study finds relatively high foscarnet concentrations in CSF in HHV-6 encephalitis
CSF foscarnet concentrati.ons were very near IC50 and were followed by sharp reductions in viral load.
Single cell transcriptomics of iciHHV-6 cell lines immortalized by EBV infection
Transcription of HHV-6 genes was rare, but occurred most often in cells with the highest levels of EBV transcription.
Are herpesviruses reactivated more often in acute COVID-19?
Systematic review and meta-analysis found strong evidence for EBV in the seriously ill; only 6 of 36 studies included HHV-6 testing.