• Foscarnet prophylaxis improved engraftment and survival in cord blood transplant patients

    Six-month overall survival was 96% in the treated group compared to 72% in the untreated group.

  • Latent HHV-6B infection of astrocytes may increase the risk of depression by activating the HPA axis

    Japanese investigators show that a protein expressed by latent HHV-6B in astrocytes, results in an influx of extra-cellular calcium, triggering the onset of depression.

  • Mothers with iciHHV6 have an increased risk of spontaneous abortion

    27.6% of Japanese mothers with iciHHV6 had a spontaneous abortion compared to 14.8% of controls. iciHHV6 mothers were also 6.4X more likely to have two or more spontaneous abortions.

  • Significantly worse outcomes in critically ill hematology patients associated with HHV-6 infection.

    Two reports associate detectable HHV-6 DNA in body fluids with increased risk of mortality in patients being treated for hematologic malignancies.

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View Post

Individuals seropositive for herpesviruses may have greater risk of dementia

Large study from UK Biobank finds that people seropositive for all of these four herpesviruses—HSV-1, HHV-6, HHV-7 and VZV—have greatly increased risk of developing dementia.

View Post

Parvovirus B19 and HHV-6 in biopsies of South African patients with acute myocarditis

Parvovirus B19 was the most common virus found, followed by EBV and HHV-6.

View Post

Coronary artery spasm often occurs in myocarditis cases with biopsy-proven HHV-6 and parvovirus B19 infection

Both viruses were associated with large vessel spasm, but parvovirus B19 was also associated with microvascular spasm.

View Post

Evidence for viral myocarditis in 2.3% of infant sudden death cases

Enteroviruses and parvovirus B19 were found more frequently than HHV-6.

View Post

Fatal myocarditis from HHV-6 in immunocompetent adult suspected of COVID-19

Case report does not distinguish HHV-6A from HHV-6B nor possible role of virus in other organ pathology.

View Post

Differentially expressed HHV-6A/B and HHV-7 genes may have prognostic value in gliomas

Unclear if viral gene expression signature confers prognostic information that is independent of host cell gene expression signatures.

View Post

Herpesvirus reactivation during alloHSCT associated with greatly increased mortality and expense

Data from 13,363 transplant patients underline the importance of preventing, diagnosing and treating viral reactivation.

View Post

Another report links HHV-6B nucleic acid and antigen to mesial temporal lobe epilepsy

Viral DNA and antigen found at higher levels in MTLE than in control brains.

View Post

HHV-6 DNA often found in cerebrospinal fluid in samples tested for meningitis

Those with viral infections showed no difference in white or red blood cell counts or the protein and glucose levels.

View Post

Artesunate compares favorably to herpesvirus antivirals in suppressing HHV-6 and HHV-7

Non-randomized study finds somewhat more potent reduction of virus in leucocytes over several months of treatment.

View Post

Virus specific T cell infusions show promise for preventing HHV-6B reactivation in transplant patients

Review highlights the importance of cell mediated immunity and the limitations of antivirals, vaccines and immunoglobulin therapy for HHV-6, VZV and HSV.

View Post

HHV-6 found in postmortem study of myalgic encephalomyelitis/chronic fatigue syndrome

Because of small number of ME/CFS subjects, the study is provocative rather than conclusive.

View Post

Increased HHV-6B viral load and levels of autonomic autoantibodies in ME/CFS

Biomarkers distinguish cases from healthy controls, but don’t all correlate with disease severity.

View Post

Reference values established for virus specific T-cells in healthy adults

These values may help determine the type of treatment transplant patients should receive: antiviral or adoptive T-cell therapy or a reduction in immunosuppression.

View Post

HHV-6 encephalitis following CAR-T cell therapy

A growing number of case reports reveal reactivation similar to that seen after hematopoietic stem cell therapy. Could CAR-T cells be a source of lytic HHV-6?

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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