A group from University College London and the University of Zambia has reported that 20.5% of hospitalized infants were positive for HHV-6B, second only to CMV (24.3%). In contrast to previous studies, HHV-6A was found in only 0.3% of patients.
Immunocompetent adults are not supposed to get HHV-6 encephalitis or status epilepticus (SE) and HHV-6 testing is rarely performed in these patients. A new case report from Baylor suggests that testing for HHV-6 in these patients may be worthwhile.
New details may help advance the field of HHV-6 immunotherapy.
New study shows HHV-6 may induce demyelination through both B and T-cell reaction. HHV-6 oligoclonal bands were also found in cases of clinically isolated syndrome.
Dr. Louis Flamand’s laboratory in Quebec, Canada, has published an article with evidence that points toward a detailed mechanism for inhibition of IL-2 gene expression by HHV-6.
Italian study finds 62% of women who developed PR early in their pregnancies miscarried
After discovering a novel human receptor (CD134) used by HHV-6B for cellular entry last year, Dr. Yasuko Mori’s group at Kobe University Graduate School of Medicine in Japan has released additional details regarding the interaction of HHV-6B its newly described receptor.
Seattle group announces the discovery of novel HHV-6 and HHV-7 homologs in pig-tailed macaques
A group of investigators in Japan have determined that HMGB-1, an inflammatory cytokine released in response to trauma, stress, and surgery, is highly elevated in DIHS/DRESS patients.
A group from Japan has conducted a retrospective study of 130 patients who underwent stem cell transplantation in an attempt to identify a risk factor for the development of encephalopathy.
HHV-6 encephalitis as a trigger in children with POLG mitochondrial disorders? Two cases of fatal Alpers-Huttenlocher syndrome
HHV-6A major capsid protein identified in CSF of MS patients: a case of molecular mimicry?
Two papers published this month highlight the potential of the new 3rd generation PCR assays in the field of HHV-6 diagnostics.
New model of HHV-6A infection demonstrates persistent abortive infection and neuroinflammation via TLR9
Dr. Hollsberg’s team at Aarhus University in Denmark has identified the protein responsible for this crucial mechanism of cell-cycle specific interruption.