HHV-6A major capsid protein identified in CSF of MS patients: a case of molecular mimicry?
New assay shows promise for diagnosis of low-grade HHV-6 infection and ciHHV-6
Two papers published this month highlight the potential of the new 3rd generation PCR assays in the field of HHV-6 diagnostics.
New mouse model of HHV-6A CNS infection developed
New model of HHV-6A infection demonstrates persistent abortive infection and neuroinflammation via TLR9
HHV-6B protein DR6 identified as inducer of cell cycle arrest in G2/M
Dr. Hollsberg’s team at Aarhus University in Denmark has identified the protein responsible for this crucial mechanism of cell-cycle specific interruption.
TNF-α predicts HHV-6 reactivation and disease progression in patients with DIHS/DRESS
While elevated TNF-a detected at the early onset of disease is a strong indicator for the early recognition of HHV-6 reactivation, this finding also reflects important therapeutic information that could be used as an early diagnostic marker of DIHS/DRESS.
Spotlight on Horvat & Reynaud from INSERM
Branka Horvat, MD, PhD, Director of Research at the International Centre for Infectiology Research in Lyon, France (INSERM), and her doctoral student Josephine Reynaud have recently published an important paper on a new transgenic mouse model
Activation of ciHHV-6 by telomeric circle formation
Additional evidence that shortened telomeres can cause the release and possible activation of integrated HHV-6.
Measles immunosuppression may cause abortive, subclinical reactivation of HHV-6
Dr. Yoshizo Asano and colleagues in Japan report that in measles immunosuppression, cells sensitized to HHV-6B immediate early and early antigen proteins may suppress replication cycles and virus formation, resulting in an “incomplete” subclinical state of reactivation.
New HHV-6 reagent available from The HHV-6 Foundation: DR7 Mab
We are pleased to announce that with the help of a few HHV-6 specialists, especially Prof. Louis Flamand from Canada, we have generated the monoclonal antibody DR-7.
REVIEW: Important differences between the HHV-6A and HHV-6B viruses
An international group of experts summarize the significant differences between the two viruses.
Human herpesvirus replication is activated by apoptosis
A group led by Steven Zeichner has published evidence that suggests the replication of all human herpesviruses can be activated by apoptosis.
Humanized mouse model demonstrates HHV-6A infection can cause significant immune dysfunction
Could treatment of HHV-6A co-infections slow AIDS progression?
MCP-1 found elevated in the CSF of patients with HHV-6B encephalopathy
Japanese group identifies several cytokine and chemokine responses associated with HHV-6B encephalopathy.
HHV-6B infection promotes unique pro-inflammatory effects tied to neurocognitive decline and artherosclerosis
HHV-6A and HHV-6B each express distinct chemokines that are uniquely capable of activating key inflammatory cytokines.
New HHV-6B specific cellular receptor identified
CD134, a member of the TNF receptor superfamily, has now been shown as a specific entry receptor for HHV-6B.
