The presence of HHV-6 and EBV DNA in nasal secretions correlates with the degree of adenoid hypertrophy in children.
HHV-6A U14 protein and NFκB activate each other
The late protein U14 of HHV-6A can induce the pro-inflammatory transcription factor NFκB, and NFκB, in turn, can encourage the replication of HHV-6A.
Different isoforms of CD46 affect infectivity and replication of HHV-6A and HHV-6B
While CD134 remains the more important receptor for HHV-6B, HHV-6B can use the CD46 receptor when a T cell has the C1 isoform of CD46.
HHV-6B may enter cells that don’t express CD134 via the nectin-2 receptor
If confirmed, finding could explain ability of HHV-6B to infect salivary, liver and neural cells.
Adding an adoptive NK cell infusion to naïve T-Cell-depleted grafts may reduce the rate of HHV-6B reactivation and encephalitis
A small pediatric study found that adoptive NK cell infusions eliminated HHV-6B encephalitis, while maintaining a low rate of GVHD. At a ratio of NK/CD4 >2, the HHV-6B reactivation rate dropped dramatically.
HHV-6, enterovirus and parvovirus B-19 found in the thyroid tissue of both autoimmune disease patients… and controls
Failure to distinguish HHV-6A from HHV-6A/B, and questions about assay sensitivity, make results difficult to interpret.
HHV-6 found to be the most frequent cause of viremia in children following HSCT
A prospective study of children transplanted for both malignant and nonmalignant disease found HHV-6 viremia in 53% of cases.
Evidence for HHV-6-induced thrombotic microangiopathy in transplant patients undergoing HSCT
Among infectious agents, HHV-6 was found to be an independent risk factor for thrombotic microangiopathy (TMA) and only HHV-6 infection was associated with TMA-related mortality.
Modulation of HHV-6B and HHV-6A infection and gene expression by CD9
The tetraspanin CD9 promotes CD46-dependent cellular infection by HHV-6A and impairs CD46-independent infection by HHV-6B.
HHV-6A and HCMV induce pro-fibrotic miRNA expression pattern in infected host cells
Pattern consistent with clinical studies suggesting these viruses may be one trigger of systemic sclerosis.
A potential mechanism by which HHV-6A infection could promote Alzheimer’s Disease
HHV-6A was found to both enhance expression and inhibit degradation of amyloid precursor protein in vitro.
The presence of HHV-6 DNA in nasal swabs correlates with neurological symptoms in patients with severe COVID-19
40% of the patients with HHV-6 DNA had CNS symptoms, compared to 14.3% of the HHV-6 negative patients.
The role of OX40 in DIHS/DRESS and HHV-6 reactivation
OX40 levels distinguished DIHS/DRESS from other inflammatory dermatologic conditions, and were associated with HHV-6 reactivation
HHV-6 as a trigger for chronic fatigue syndrome: a meta-analysis
Systematic review and meta-analysis confirm an association, but not a causal link, between HHV-6 and CFS
Viral reactivation may be one cause of febrile neutropenia in chemotherapy patients
HHV-6 was the most prevalent virus in febrile neutropenia episodes among pediatric patients