These values may help determine the type of treatment transplant patients should receive: antiviral or adoptive T-cell therapy or a reduction in immunosuppression.
HHV-6 encephalitis following CAR-T cell therapy
A growing number of case reports reveal reactivation similar to that seen after hematopoietic stem cell therapy. Could CAR-T cells be a source of lytic HHV-6?
The dUTPases of HHV-6A and EBV may encourage autoimmunity in ME/CFS
Viral dUTPases are strong inducers of activin A and enhance T follicular helper-cell differentiation.
Elevated HHV-6 and EBV dUTPase antibody levels found in older populations
It remains unclear if there are lower levels of these antibodies in younger age groups.
Reactivation of latent herpesviruses and HERVS after mild COVID-19
Findings are accentuated in people with myalgic encephalomyelitis/chronic fatigue syndrome.
Differences in the cytopathic effect of HHV-6A and HHV-6B infection of neurons and glia
In vitro studies confirm that the two viruses infect different cell types, and generate different cytopathic effects, cytokine and growth factor responses.
Two HHV-6 genes may contribute to pathogenesis of autoimmune thyroiditis
Genes U12 and U51 encode homologues of human G-protein-coupled receptors, and are potential triggers of autoimmunity.
Murine roseolovirus (MRV) infection experiments are only partially supportive of role of HHV-6A/B in Alzheimer’s disease
While MRV administered peripherally led to brain infection and neuroinflammation, it did not increase Aß deposition
HHV-6A promotes inflammation in astrocytoma cells by dysregulating autophagy
Infection increases ROS, induces ER stress and activates STAT3, NF-κB and mTOR pathways.
EBV and HHV-6 plasma viremia is infrequent at Day 7 during acute COVID-19
Other studies have suggested that reactivation of these viruses could theoretically contribute to a hyperinflammatory state or autoimmune disorders in acute COVID-19, but this study does not provide evidence of that.
Possible link between depression and HHV-6 infection in childhood
Serologic studies of several herpesviruses find that only HHV-6 may be linked to depression.
Does inherited chromosomal integration of HHV-6 at 9q increase the risk of malignancy?
A large study of iciHHV-6 integration sites found integration at 9q more common in hematologic malignancies—but the study lacked power to draw firm conclusions.
New seroepidemiological evidence that HHV-6 contributes to MS disease progression
Longitudinal study of people with a single initial episode of demyelination provides stronger evidence for HHV-6 than EBV in the pathogenesis of MS, but the evidence is not robust.
Development of highly sensitive technique for detecting viral DNA sequences in cell-free plasma
Isolating DNA fragments less than 120 base pairs enriches for viral vs. cellular DNA.
Resected tonsil and adenoid tissues harbor high viral loads of HHV-6, HHV-7 and EBV as well as respiratory viruses
HHV-6 was found in 33% of adenoid and 45% of tonsil tissues, with the highest rates found in younger children.