Study finds value in HHV-6 testing of other tissues, as well as blood, and of routine testing for iciHHV-6 in both donors and recipients of allo-HCT.
Stanford WGS study: Widespread integration and reactivation of HHV-6B and HHV-7 in lymphoblastoid cells immortalized with EBV
EBV infected B cells may represent a site of HHV-6 latency.
Individuals seropositive for herpesviruses may have greater risk of dementia
Large study from UK Biobank finds that people seropositive for all of these four herpesviruses—HSV-1, HHV-6, HHV-7 and VZV—have greatly increased risk of developing dementia.
Parvovirus B19 and HHV-6 in biopsies of South African patients with acute myocarditis
Parvovirus B19 was the most common virus found, followed by EBV and HHV-6.
Coronary artery spasm often occurs in myocarditis cases with biopsy-proven HHV-6 and parvovirus B19 infection
Both viruses were associated with large vessel spasm, but parvovirus B19 was also associated with microvascular spasm.
Evidence for viral myocarditis in 2.3% of infant sudden death cases
Enteroviruses and parvovirus B19 were found more frequently than HHV-6.
Fatal myocarditis from HHV-6 in immunocompetent adult suspected of COVID-19
Case report does not distinguish HHV-6A from HHV-6B nor possible role of virus in other organ pathology.
Differentially expressed HHV-6A/B and HHV-7 genes may have prognostic value in gliomas
Unclear if viral gene expression signature confers prognostic information that is independent of host cell gene expression signatures.
Herpesvirus reactivation during alloHSCT associated with greatly increased mortality and expense
Data from 13,363 transplant patients underline the importance of preventing, diagnosing and treating viral reactivation.
Another report links HHV-6B nucleic acid and antigen to mesial temporal lobe epilepsy
Viral DNA and antigen found at higher levels in MTLE than in control brains.
HHV-6 DNA often found in cerebrospinal fluid in samples tested for meningitis
Those with viral infections showed no difference in white or red blood cell counts or the protein and glucose levels.
Artesunate compares favorably to herpesvirus antivirals in suppressing HHV-6 and HHV-7
Non-randomized study finds somewhat more potent reduction of virus in leucocytes over several months of treatment.
Virus specific T cell infusions show promise for preventing HHV-6B reactivation in transplant patients
Review highlights the importance of cell mediated immunity and the limitations of antivirals, vaccines and immunoglobulin therapy for HHV-6, VZV and HSV.
HHV-6 found in postmortem study of myalgic encephalomyelitis/chronic fatigue syndrome
Because of small number of ME/CFS subjects, the study is provocative rather than conclusive.
Increased HHV-6B viral load and levels of autonomic autoantibodies in ME/CFS
Biomarkers distinguish cases from healthy controls, but don’t all correlate with disease severity.