• Antibodies to HHV-6 during acute COVID-19 may help predict development of Long COVID

    Autoantibodies directed against neural targets have most predictive power.

  • iciHHV-6B linked to systemic lupus erythematosus (SLE) in Japanese and European populations

    iciHHV-6B, when integrated into chromosome 22q, was strongly associated with SLE and with SLE severity.

  • HHV-6 linked to miscarriage through Mendelian randomization studies

    The findings are consistent with previous studies directly linking HHV-6 endometrial infection to miscarriage.

  • Finnish investigators find unexpected evidence of HHV-6B integration into mitochondrial DNA

    Could HHV-6B infection exacerbate mitochondrial disease?

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Latest HHV-6 Research Articles

View Post

Systematic review: HHV-6 causes 77% of encephalitis cases in hematopoietic cell transplant patients, with a high mortality rate

In All by Kristin LoomisAugust 5, 2023

1.1% of 72,423 HCT patients developed encephalitis with an all-cause mortality rate of 60%.

View Post

12th International Conference on HHV-6 & 7 Announced

In All by Kristin LoomisSeptember 29, 2022

The 12th International Conference on HHV-6 & 7 will convene in Japan at the Himeji Culture and Convention Center in March 2025.

View Post

Differentiating incidental from disease-causing HHV-6 infections in pediatric spinal fluid samples

In All by Kristin LoomisAugust 5, 2023

Clinical assessment revealed that 91% of iciHHV-6 cases and 33% of non-iciHHV-6 cases were incidental.

View Post

BioFire assay identifies HHV-6 as the most frequent cause of meningoencephalitis in infants 4-11 months

In All, ciHHV-6, CNS Disease, Encephalitis & Encephalopathy, Epilepsy and Seizures by Kristin LoomisAugust 4, 2023

All cases found to be iciHHV-6 were assumed to be false positives.

View Post

High levels of HHV-6A DNA found in blood of 52% of kidney transplant patients

In All, Kidney Disease, Transplant Complications by Kristin LoomisAugust 4, 2023

HHV-6A was the most common virus identified, but was not linked to worse outcomes compared to other viral infections.

View Post

A tribute to Dharam Ablashi

In All by Kristin LoomisJuly 3, 2023

The HHV-6 field has lost a pioneer.

View Post

DRESS, a syndrome linked to viral reactivation, may be triggered by several antivirals

In All, Antiviral, Drug Hypersensitivity by Kristin LoomisJuly 3, 2023

Ribavarin, ritonavir, abacavir and lamivudine were the primary triggers.

View Post

Small study finds relatively high foscarnet concentrations in CSF in HHV-6 encephalitis

In All, Antiviral, Encephalitis & Encephalopathy, Transplant Complications, Treatments - Antiviral by Kristin LoomisJuly 3, 2023

CSF foscarnet concentrati.ons were very near IC50 and were followed by sharp reductions in viral load.

View Post

Single cell transcriptomics of iciHHV-6 cell lines immortalized by EBV infection

In All, Genes, iciHHV-6 by Kristin LoomisJuly 3, 2023

Transcription of HHV-6 genes was rare, but occurred most often in cells with the highest levels of EBV transcription.

View Post

Are herpesviruses reactivated more often in acute COVID-19?

In All, Autoimmune Disease, COVID, COVID-19 / HHV-6 Reactivation by Kristin LoomisJuly 3, 2023

Systematic review and meta-analysis found strong evidence for EBV in the seriously ill; only 6 of 36 studies included HHV-6 testing.

View Post

Using CRISPR to excise integrated HHV-6A from latently infected cells and iciHHV6 patient cell lines, in vitro

In All, Genes, Latest Scientific News by Kristin LoomisMay 21, 2023

Advance may aid the study of integration and excision and might ultimately have clinical application.

View Post

Coinfection of CMV and HHV-6A boosts fibrosis-associated microRNAs in fibroblasts

In All, Autoimmune Disease, Liver Disease, Lung Disease, Rash & Roseola by Kristin LoomisMay 21, 2023

Investigators see possible links to systemic sclerosis, liver fibrosis and cardiovascular remodeling.

View Post

Severe hepatitis in young children has novel viral cause

In All, Hepatitis by Kristin LoomisMay 21, 2023

Adeno-associated virus2 plus coinfecting adenoviruses and possibly HHV-6 revealed as causes.

View Post

The relationship of telomere length to HHV-6 integration

In All, ciHHV-6, Latest Scientific News by Kristin LoomisMarch 30, 2023

Telomere length does not appear to influence the efficiency of viral integration, and viral integration may not affect telomere length.

View Post

Uncontrolled evidence suggests immunosuppression may be safe and effective in lymphocytic myocarditis patients with biopsies positive for HHV-6 by qPCR

In All, ciHHV-6, Latest Scientific News by Kristin LoomisMarch 30, 2023

Steroids reduced cardiac inflammation in 70% and improved ejection fraction in 80% without an increase in viral load.

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ABOUT THE HHV-6 FOUNDATION

The HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B.

The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease. Since HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge.

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