1.1% of 72,423 HCT patients developed encephalitis with an all-cause mortality rate of 60%.
12th International Conference on HHV-6 & 7 Announced
The 12th International Conference on HHV-6 & 7 will convene in Japan at the Himeji Culture and Convention Center in March 2025.
Differentiating incidental from disease-causing HHV-6 infections in pediatric spinal fluid samples
Clinical assessment revealed that 91% of iciHHV-6 cases and 33% of non-iciHHV-6 cases were incidental.
BioFire assay identifies HHV-6 as the most frequent cause of meningoencephalitis in infants 4-11 months
All cases found to be iciHHV-6 were assumed to be false positives.
High levels of HHV-6A DNA found in blood of 52% of kidney transplant patients
HHV-6A was the most common virus identified, but was not linked to worse outcomes compared to other viral infections.
A tribute to Dharam Ablashi
The HHV-6 field has lost a pioneer.
DRESS, a syndrome linked to viral reactivation, may be triggered by several antivirals
Ribavarin, ritonavir, abacavir and lamivudine were the primary triggers.
Small study finds relatively high foscarnet concentrations in CSF in HHV-6 encephalitis
CSF foscarnet concentrati.ons were very near IC50 and were followed by sharp reductions in viral load.
Single cell transcriptomics of iciHHV-6 cell lines immortalized by EBV infection
Transcription of HHV-6 genes was rare, but occurred most often in cells with the highest levels of EBV transcription.
Are herpesviruses reactivated more often in acute COVID-19?
Systematic review and meta-analysis found strong evidence for EBV in the seriously ill; only 6 of 36 studies included HHV-6 testing.
Using CRISPR to excise integrated HHV-6A from latently infected cells and iciHHV6 patient cell lines, in vitro
Advance may aid the study of integration and excision and might ultimately have clinical application.
Coinfection of CMV and HHV-6A boosts fibrosis-associated microRNAs in fibroblasts
Investigators see possible links to systemic sclerosis, liver fibrosis and cardiovascular remodeling.
Severe hepatitis in young children has novel viral cause
Adeno-associated virus2 plus coinfecting adenoviruses and possibly HHV-6 revealed as causes.
The relationship of telomere length to HHV-6 integration
Telomere length does not appear to influence the efficiency of viral integration, and viral integration may not affect telomere length.
Uncontrolled evidence suggests immunosuppression may be safe and effective in lymphocytic myocarditis patients with biopsies positive for HHV-6 by qPCR
Steroids reduced cardiac inflammation in 70% and improved ejection fraction in 80% without an increase in viral load.