Autopsy brain samples from 51 controls and 57 patients who died with encephalopathy of unknown origin were tested for HHV-6 & HHV-7 using immunohistochemistry, nested and real time PCR.
A prospective study authored by Joshua Hill and Danielle Zerr determined that higher than average HHV-6B DNA levels increased the odds of developing delirium after cord blood transplantation (CBT) by almost three fold. Patients with DNA loads in the top quartile had a 4.5 fold increase in delirium.
Two new reviews conclude that HHV-6 acute necrotizing encephalopathy is tied to a mutation of the RANBP2 gene.
Tehran University of Medical Sciences reports HHV-6 DNA in cerebrospinal fluid (CSF) samples of 8.8% of 114 infants suspected of encephalitis.
Experts emphasize need for larger studies to determine the impact of ciHHV-6 on patient outcomes
Edaravone shows promise for reducing oxidation and neuronal damage in AESD.
Should physicians automatically discount HHV-6 if any other pathogen is found in the CSF? Should patients with both HHV-6 and EBV DNA in the CSF be treated only for EBV? These are the questions that UW group tried to sort out in this study.
A group from Japan has conducted a retrospective study of 130 patients who underwent stem cell transplantation in an attempt to identify a risk factor for the development of encephalopathy.
HHV-6 encephalitis as a trigger in children with POLG mitochondrial disorders? Two cases of fatal Alpers-Huttenlocher syndrome
Japanese group identifies several cytokine and chemokine responses associated with HHV-6B encephalopathy.
Case report describes child with multiple episodes of febrile status epilepticus, followed by chorea and developmental regression, caused by human herpes virus-6 encephalitis.
A group from Fujita Health University has identified the first known case of posterior reversible encephaliopathy syndrome (PRES) associated with HHV-6B encephalitis.
New study shows that patients who develop HHV-6 encephalitis have a significantly poor prognosis
International group calls for routine HHV-6 surveillance in all cases of UCBT
New study from Harvard finds heightened risk of HHV-6 PALE for UCBT patients.