Should physicians automatically discount HHV-6 if any other pathogen is found in the CSF? Should patients with both HHV-6 and EBV DNA in the CSF be treated only for EBV? These are the questions that UW group tried to sort out in this study.
The University of Washington and the Fred Hutchinson Cancer Research Center are at the forefront of studying the role of HHV-6 and ciHHV-6 in stem cell transplant patients. We asked their view on the implications immunocompromised patients with integrated HHV-6A reactivating with their own inherited virus.
HHV-6 reactivation before engraftment strongly predictive of graft failure
Trial explores immunotherapy for opportunistic viruses in transplantation
A group from Tokyo Medical University has determined that low level HHV-6 reactivation, but not CMV, EBV or HHV-7 reactivation, is a predictive marker for the development of grade 2-4 acute GVHD after hematopoietic stem cell transplantation (HSCT).
A team of Japanese investigators led by Tetsushi Yoshikawa found evidence of mixed infections of human herpesvirus 6B (HHV-6B) in two out of 15 stem cell transplant patients.
Study links HHV-6 reactivation to increasingly poor outcome following myeloablative HSCT
HHV-6 detection associated with increasingly poor outcome for stem cell transplant patients.
Researchers have tied HHV-6 Reactivation to GVHD, seizures, pneumonia, and encephalitis in Allo-SCT patients.