The University of Washington and the Fred Hutchinson Cancer Research Center are at the forefront of studying the role of HHV-6 and ciHHV-6 in stem cell transplant patients. We asked their view on the implications immunocompromised patients with integrated HHV-6A reactivating with their own inherited virus.
HHV-6 reactivation before engraftment strongly predictive of graft failure
Trial explores immunotherapy for opportunistic viruses in transplantation
A group from Tokyo Medical University has determined that low level HHV-6 reactivation, but not CMV, EBV or HHV-7 reactivation, is a predictive marker for the development of grade 2-4 acute GVHD after hematopoietic stem cell transplantation (HSCT).
A team of Japanese investigators led by Tetsushi Yoshikawa found evidence of mixed infections of human herpesvirus 6B (HHV-6B) in two out of 15 stem cell transplant patients.
Study links HHV-6 reactivation to increasingly poor outcome following myeloablative HSCT
HHV-6 detection associated with increasingly poor outcome for stem cell transplant patients.
Researchers have tied HHV-6 Reactivation to GVHD, seizures, pneumonia, and encephalitis in Allo-SCT patients.